Editori e Revisori del NEJM e i Diabetologi ignorano il Reale Rischio Congenito del T2DM, Epidemia in continuo aumento.

Considero un imperativo categorico per un Medico – ancora libero di pensare e sperimentare – informare la gente sulla Prevenzione Pre-Primaria e Primaria delle più frequenti e gravi malattie croniche degenerative.

Per questo motivo, come annunciato  ai Destinatari, pubblico questa mail, ennesimo mio J’Accuse contro la Medicina, Serva dell’Economia, che ignora l’altra faccia della Medaglia Diagnositico-Terapeutica, non politicamente corretta: Diagnosi e Terapia della malattia in potenza, cioè la Prevenzione Pre-Primaria e Primaria.

——– Messaggio Inoltrato ——–

Oggetto:	My clinical fight against T2DM
Data:	Thu, 5 Apr 2018 10:17:31 +0200
Mittente:	Sergio Stagnaro <dottsergio@semeioticabiofisica.it>
A:	Jennifer.Lyn.Baker@regionh.dk, lise.geisler.bjerregaard@regionh.dk, NEJM Editorial <editorial@nejm.org>
CC:	Maddalena Ceredi <m.ceredi@fimo.biz>, editor@sciencedaily.com, editor@bmj.com, science_editors@aaas.org, jamams <jamams@jamanetwork.org>, diabetologia-j@bristol.ac.uk, diabetes@joslin.harvard.edu, DiabetesCare@diabetes.org

Dear NEJM Editors,

Dear Authors of the distressing,  not updated article in NEJM current issue  Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes,  Lise G. Bjerregaard, Ph.D., Britt W. Jensen, Ph.D., Lars Ängquist, Ph.D.,Merete Osler, D.M.Sc.,,Thorkild I.A. Sørensen, D.M.Sc., and Jennifer L. Baker, Ph.D, Britt W. Jensen, Ph.D.,et al.

“Childhood overweight at 7 years of age was associated with increased risks of adult type 2 diabetes only if it continued until puberty or later ages. (Funded by the European Union)”.  It’s not possible to become diabetic without Diabetic “and” Dislipidemic Constitution-Dependent, Inherited Real Risk, bedside diagnosed from birth, using a common stethoscope,  and removed by Reconstructing Mitochondrial Quantum Therapy:

Stagnaro-Neri M., Stagnaro S., Il diagramma linfatico dell’arto superiore nella diagnosi clinica percusso-ascoltatoria del diabete mellito. III Congr. Intern. Di Flebolinfologia. Ferrara-San Marino, 18-21 Settembre. Atti 21-11, 1992

Stagnaro-Neri M., Stagnaro S., Il Segno di Bilancini-Lucchi nella diagnosi clinica del diabete mellito. The Pract. Ed. It. 176, 30, 1993

Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [Medline] ;

Sergio Stagnaro and Simone Caramel.    Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology (Lausanne). 2013; 4: 17. http://www.frontiersin.org/Review/ReviewForum.aspx  [Medline] :

Simone Caramel, Marco Marchionni  and Sergio Stagnaro. The Glycocalyx Bedside Evaluation Plays A Central  Role in Diagnosing Type 2 Diabetes Mellitus and in its Primary Prevention. Treatment Strategies – Diagnosing Diabetes, Cambridge Research Centre, Volume 6 Issue 1, Pg 41-43. http://viewer.zmags.com/publication/0aafcae9#/0aafcae9/1

Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov/pubmed/25743850[MEDLINE]

Unfortunately, it is clear that neither the NEJM Editors and Reviewers nor you Authors jet  understand what account for the reason of T2DM onset,  today’s growing epidemic: in 2030, tere is a general agreement that 360,000,000 of diabetics are expected, demonstrating the defeat of the present Medicine, that rejects, hides, masks  the Pre-Primary and Primary Prevention, according to Quantum Biophysical Semeiotic .

Next April, 28, in Bologna (Italy) i will illustrate once again at Istituto Oropedico Rizzoli, my inexpensive, clinical fight against T2DM: See Attachment.

This mail will be posted in my blog at LINK https://sergiostagnaro.wordpress.com/:  people have the right to know how to save themselves from T2DM

Sincerely

Dr Sergio Stagnaro

Sergio Stagnaro MD

Via Erasmo Piaggio 23/8

16039 Riva Trigoso (Genoa) Italy

Founder of Quantum Biophysical Semeiotics

Honorary President of International Society of

Quantum Biophysical Semeiotics

Cell. 3338631439

dottsergio@semeioticabiofisica.it

www.semeioticabiofisica.it

www.sisbq.org

www.sergiostagnaro.wordpress.com

Pubblicità

Le Autorità Sanitarie competenti spiegheranno a Roma il 3 Novembre pv la necessità delle vaccinazioni. La mia risposta in una mail.

Caro Lettore, non ritengo necessario aggiungere un commento al contenuto della seguente mail. Che Dio continui ad amarci, nonostante tutto. Buon Giubileo.

——– Messaggio Inoltrato ——–

Oggetto:	Fwd: Perché vaccinarsi: il ruolo dei media per una cultura della prevenzione,
Data:	Sat, 29 Oct 2016 07:55:46 +0200
Mittente:	Sergio Stagnaro <dottsergio@semeioticabiofisica.it>
A:	Walter Ricciardi ISS <walter.ricciardi@unicatt.it>, segreteriaministro@sanita.it, presidenza@fnomceo.it
CC:	ordinemedici@omceoge.eu, SISBQ mailing list <sisbq_medicaldoctors@yahoogroups.com>, Usai Salvatore <salvusai@alice.it>, Giorgio celfood Terziani <info@eurodream.net>

 

Illustri Destinatari,

dopo aver letto la seguente mail, alla luce di quanto ho scritto sulle vaccinazioni (Tre articoli critici costruttivi:

https://sergiostagnaro.wordpress.com/…/il-non-detto-da-dir…/
https://sergiostagnaro.wordpress.com/…/il-non-detto-da-dir…/
https://sergiostagnaro.wordpress.com/…/il-non-detto-da-dir…/ ) chiedo di poter illustrare, salute permettendo (85 aa. ed esiti di vecchio IMA)  il mio pensiero sulle vaccinazioni il 3 Novembre 2016 nell’Auditorium del Ministero della Salute, con un intervento pre-ordinato della durata di 15 minuti.
Nell’occasione porrò a tutti gli illustri organizzatori del corso di aggiornamento “Perché vaccinarsi: il ruolo dei media per una cultura della prevenzione” (Di quale prevenzione? forse lo screening? NdR!), la domanda finora inevasa da voi tutti:
“Se vaccinarsi , per esempio, contro l’influenza, è scientificamente doveroso e moralmente giustificato, alla condizione che si conoscano i Reali Rischi Congeniti, dipendenti dalle Costituzioni Semeiotico-Biofisico-Quantistiche dei vaccinandi., allora perché continuate ad ignorare la non-costosa Prevenzione Pre-Primaria – http://www.sisbq.org/qbs-magazine.html – e Primaria su scala nazionale di CVD/CAD, T2DM, Osteoporosi e Cancro, epidemie in continuo aumento e prime cause di morte?”.

Sergio Stagnaro and Simone Caramel (2013). The Inherited Real Risk of Coronary Artery Disease, EJCN, European Journal Clinical Nutrition, Nature PG., 67, 683 (June 2013) doi:10.1038/ejcn.2013.37. [MEDLINE]

Sergio Stagnaro and Simone Caramel (2012). Quantum Therapy: A New Way in Osteoporosis Primary Prevention and Treatment. Journal of Pharmacy and Nutrition Sciences, (27 June 2012) | doi:10.1038/ejcn.2012.76, http://www.nature.com/doifinder/10.1038/ejcn.2012.76. PMID:22739250  [MEDLINE]

Simone Caramel and Sergio Stagnaro (2012).   Vascular calcification and Inherited Real Risk of lithiasis. Front. In Encocrin.  3:119. doi: 10.3389/fendo.2012.00119 http://www.frontiersin.org/Bone_Research/10.3389/fendo.2012.00119/full [MEDLINE]

Sergio Stagnaro and Simone Caramel (2013).    Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology. 26 February 2013 | http://dx.doi.org/10.3389/fendo.2013.00017; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581808/[MEDLINE] Sergio

Stagnaro and Simone Caramel.  The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.org/Epigenomics_and_Epigenetics/10.3389/fgene.2013.00055/full  [MEDLINE]

Sergio Stagnaro and Simone Caramel.  BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention.  Front. Genet. | doi: 10.3389/fgene.2013.00039.  http://www.frontiersin.org/Cancer_Genetics/10.3389/fgene.2013.00039/full [MEDLINE]

Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. https://www.researchgate.net/publication/273147071_Morinda_citrifolia_Plays_a_Central_Role_in_the_Primary_Prevention_of_Mitochondrial-dependent_Degenerative_Disorders

http://www.ncbi.nlm.nih.gov/pubmed/25743850 [MEDLINE]

Per onestà intellettuale, vi informo che pubblicherò  tra poco la presente mail in LA VOCE di SS https://sergiostagnaro.wordpress.com

In attesa delle vostre risposte, che metterò in rete nel sito sopra riferito, porgo distinti saluti.

Dr Sergio Stagnaro

Sergio Stagnaro MD

Via Erasmo Piaggio 23/8,

16039 Riva Trigoso (Genoa) Italy

Phone 0390-0185-42315

Founder of Quantum Biophysical Semeiotics,

Honorary President of International Society of

Quantum Biophysical Semeiotics (SISBQ)

www.semeioticabiofisica.it

www.sisbq.org

www.sergiostagnaro.wordpress.com

 

——– Messaggio Inoltrato ——–

Oggetto:	Perché vaccinarsi: il ruolo dei media per una cultura della prevenzione,
Data:	Sat, 29 Oct 2016 03:23:28 +0200
Mittente:	newsletter@media.fnomceo.it <newsletter@media.fnomceo.it>
Rispondi-a:	newsletter@media.fnomceo.it <newsletter@media.fnomceo.it>
A:	dottsergio@semeioticabiofisica.it

 

Giovedì 3 novembre, a Roma, dalle 8,30 alle 14,30 presso l’Auditorium del Ministero della Salute, si svolgerà il corso di aggiornamento “Perché vaccinarsi: il ruolo dei media per una cultura della prevenzione”, organizzato dalla FNOMCeO  insieme all’Eaci (European Association on Consumer Information, Gruppo di Specializzazione della FNSI) con l’appoggio del Ministero della Salute e il Patrocinio della Federazione della Stampa.

Sono di pochi giorni fa i nuovi dati del Ministero della Salute sul calo delle coperture vaccinali nei bambini sotto i due anni, che per alcune malattie potrebbero non far raggiungere l’immunità di gregge. Intanto il Piano Vaccinale, appena presentato dal Governo, è già a rischio per i tagli ventilati dal Ministero dell’Economia. In questo scenario i cittadini sono disorientati da annunci allarmistici sulla sicurezza o abbandonati alle sempre più subdole e seduttive lusinghe dei falsi esperti. Per fare chiarezza, la FNOMCeO ha fortemente voluto il corso “Perché vaccinarsi: il ruolo dei media per una cultura della prevenzione”
Il corso è organizzato dalla Fnomceo insieme all’Eaci con l’appoggio del Ministero della Salute, e il Patrocinio della Federazione della Stampa, e accreditato tramite l’Ordine dei Giornalisti del Lazio, per sottolineare il valore di un percorso comune tra le due professioni, nell’ottica di una cultura della prevenzione e della Salute.
Tra i relatori, oltre al  Ministro della Salute Beatrice Lorenzin e al  Presidente della FNOMCeO, Roberta Chersevani, vi saranno il Presidente dell’Istituto Superiore di Sanità, Walter Ricciardi, la Presidente del Consiglio Superiore di Sanità, Roberta Siliquini, e molti medici e docenti universitari. Come relatori giornalisti parteciperanno: Piero Angela, Gerardo D’Amico e il Referente Eaci in seno alla FNSI, il Segretario Mattia Motta. (leggi di più…). Convegno_FNOMCEO-EACI Programma 

Alle ore 10 si terrà una Conferenza Stampa congiunta FNOMCeO- Ministero sulle strategie di resistenza al Tar contro i ricorsi presentati da Codacons, in particolare quello contro il Documento sui Vaccini approvato all’unanimità lo scorso 8 luglio dal Consiglio Nazionale FNOMCeO.

L’evento è gratuito e accreditato nell’ambito del Programma di Formazione Professionale Continua per 6 crediti (sono aperte le iscrizioni sulla piattaforma Sigef).

 

 

 

NEJM: Questa non è la Medicina del Nuovo Rinascimento

Quo Vadis Medicinae?

Chiunque, sano di mente, dalla lettura della seguente mail può comprendere che Mala Tempora currunt nel Regno della presente Medicina della sconfitta voluta, in cui è impensabile che le redditizie epidemie di CVD/CAD, T2DM, Osteoporosi, Cancro potranno essere sconfitte in tempi brevi.

——– Messaggio Inoltrato ——–

Oggetto:	Cardiac and Renovascular “Complications” in T2DM? Astonishing no-updated news.
Data:	Thu, 16 Jun 2016 08:35:16 +0200
Mittente:	Sergio Stagnaro <dottsergio@semeioticabiofisica.it>
A:	jingelfinger@partners.org, rosenc@mmc.org, editorial@nejm.org

Dear Prof. Julie R. Ingelfinger, M.D.,
Dear Prof. Clifford J. Rosen, M.D.,
Dear NEJM Editors,

in Journal current issue, the Editorial Cardiac and Renovascular Complications in Type 2 Diabetes — Is There Hope? Julie R. Ingelfinger, M.D., and Clifford J. Rosen, M.D.  June 14, 2016DOI: 10.1056/NEJMe1607413 is fundamentally biased and unfortunately no-updated (1-40).

Despite neither NEJM Editors and Reviewers nor the paper’s Authors till now know Quantum Biophysical Semeiotics Constitution-dependent Inherited Real Risks,  cardiac and renovascular disorders aren’t Complications in Type 2 Diabetes.   I congratulate the ambigous in (scritto in ROSSO nella mail. NdR) is the logo of roman Prudentia senescentis. I consider it really excellent. However these disorders of what are Complications if Authors have written in Type 2 Diabetes? Could someone explain me these intriguing dilemma?
There is not a diabetic microangiopathy, because it is typical of diabetic micorovasculare damage only one precise alteration in S segment of Hoyer corpuscle: Sergio Stagnaro. “Microangiopatia diabetica”, Fondamento dell’Epidemia Diabetica. In La Voce di SS., 17/08/2013.

https://sergiostagnaro.wordpress.com/tag/la-cosiddetta-microangiopatia-diabetica/

Surely, even NEJM Editors, Reviewers and Authors are told that not all diabetics are also suffering for CVD/CAD or nehropathy.
In fact, without the relative Constitution-Dependent, Inherited Real Risks, all environmental risk factors are innocent bystanders:  Sergio Stagnaro. Without CAD Inherited Real Risk, All Environmental Risk Factors of CAD are innocent Bystanders. Canadian Medical Association Journal. CMAJ, 14 Dec 2009,  http://www.cmaj.ca/cgi/eletters/181/12/E267#253801.

Importantly, bedside recognized, i.e., with a common stethoscope, from birth,  these heritable predispositions to diseases, based on a mitochondrial cytopathy, namely CAEMH, I have discovered 36 years ago (1-40), but yet unfortunately overlooked by you all, can be removed completely by inexpensive Restructuring Mitochondrial Quantum Therapy:

http://www.sisbq.org/uploads/5/6/8/7/5687930/tq_italian_english_agg.pdf

Contradictory, but very fun, is  the following recent comment, accepted and than posted in the NEJM website:
http://www.nejm.org/doi/full/10.1056/NEJMoa1516192#t=comments

SERGIO STAGNARO, MD | Physician – DIABETES | Disclosure: None

RIVA TRIGOSO Italy

June 08, 2016

Oncological Terrain-Dependent,Inherited Real Risk of Leukemia

In 2000, I have discovered and described, beside a flurry of other Inherited Real Risks, dependent on related Constitutions (CVD/CAD, T2DM, Osteoporosis, a.s.o.) Oncological Terrain-Dependent, Leukemia Inherited Real Risk, bedside diagnosed in quantitative manner from birth, using a common stethoscope. Interestingly, all these predispositions to disorders are removed by inexpensive Restructuring Mithocondrial Quantum Therapy. Extremely important from primary prevention of every disorder, now growing epidemics, the mothers of all patients are positive (100%) to the identical inherited real risk. References on request of NEJM only.

1. I am going to post this mail in my La Voce di SS,www.sergiostagnaro.wordpress.com , so that this mail cannot be considered a submission for beeng published as Correspondence on the NEJM!

REFERENCES

 

1) Sergio Stagnaro   (29 May 2008) Bedside Recognizing CAD Inherited Real Risk and silent CAD with Biophysical Semeiotics. http://www.lipidworld.com/content/7/1/19/comments

 

2) Sergio Stagnaro and Simone Caramel (2012) Quantum Biophysical Semeiotics Microcirculatory Theory of Arteriosclerosis – www.sisbq.org, Journal of Quantum Biophysical Semeiotics, first version, http://www.sisbq.org/uploads/5/6/8/7/5687930/ats_qbs__mctheory.pdf

 

3) Sergio Stagnaro, Use of multiple markers and improvement of the prediction model for cardiovascular mortality, www.nature.com, 21 May, 2008 http://network.nature.com/forums/pmgs/1587?page=1

 

4)   Stagnaro Sergio.    CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. International Atherosclerosis Society. www.athero.org, 29 April, 2009  http://www.athero.org/commentaries/comm907.asp

 

5) Sergio Stagnaro Bed-side biophysical semeiotic recognizing CAD “inherited real risk” and overt CAD, event silent. l: (18 October 2003). www.bmj.com, http://www.bmj.com/cgi/eletters/327/7420/895

 

6) Sergio Stagnaro Assessing NK cell compartment in individuals with CAD Inherited Real Risk. Immunity & Aging, (14 May 2007), http://www.immunityageing.com/content/4/1/3/comments

 

7) Sergio Stagnaro. Bedside Biophysical-Semeiotic Recognizing CAD Real Risk and silent CAD. Journal Review, http://journalreview.org/v2/articles/view/16449729.html

 

8) Sergio Stagnaro. A Clinical Biophysical-Semeiotic Contribution reliable in prompt recognizing CAD, even silent. BMC.Cardiovascular Disorders, 2005, http://www.biomedcentral.com/1471-2261/5/5/comments

 

9)   Sergio Stagnaro. Without CAD Inherited Real Risk, All Environmental Risk Factors of CAD are innocent Bystanders. Canadian Medical Association Journal. CMAJ, 14 Dec 2009,  http://www.cmaj.ca/content/181/12/E267/reply

 

10)                 Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology, 2007. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php

 

11)                   Sergio Stagnaro.  A Clinical Method far better than Blood Cell Count in CAD Primary Prevention. www.bmj.com, 2005, http://www.bmj.com/cgi/eletters/330/7493/690

 

12)   New bedside way in Reducing mortality in diabetic men and women.

Ann Int Med.2007. http://www.annals.org/cgi/eletters/147/3/149

 

12)                   Sergio Stagnaro.  Biophysical Semeiotics is really useful in order to bed-side recognizing heart ischaemic disease, even before its onset, i.e., real risk of coronary artery disease. BMC. Cardiovascular Diseases, 2004, http://www.biomedcentral.com/1471-2261/3/12/comments

 

13) Stagnaro Sergio.   Bedside Evaluation of CAD biophysical-semeiotic inherited real risk under NIR-LED treatment. EMLA Congress, Laser Helsinki August 23-24, 2008. “Photodiagnosis and photodynamic therapy”, Elsevier, Vol. 5 suppl 1 august 2008 issn 1572-1000.

 

14) Sergio Stagnaro    Biophysical-Semeiotic Diagnosing Cad “real” risk, as well as pre-clinical and clinical CAD.  www.bmj.com, (12 September 2003) http://bmj.bmjjournals.com/cgi/eletters/327/7415/591

 

15)                   Sergio Stagnaro    Bedside Biophysical Semeiotic Evaluation of Acute Phase Proteins. Ann Family Med. 2008, http://www.annfammed.org/cgi/eletters/6/2/100

 

16)   Sergio Stagnaro.  EBM “and” Single Patient Based Medicine, Medical News today, 2007, http://www.medicalnewstoday.com/youropinions.php?opinionid=23466

 

17) Sergio Stagnaro. Inherited Real Risk of CAD and Cancer, www.nature.com, 2008, http://blogs.nature.com/news/thegreatbeyond/2008/01/can_shining_lights_on_your_hea_1.html

 

18) Sergio Stagnaro (2012). I Segni di Caotino* e di Gentile** nella Diagnosi di Reale Rischio Congenito di CAD e di Infarto Miocardico, ancorché iniziale o silente. Fisiopatologia e Terapia. Lectio Magistralis. III Convegno della SISBQ, 9-10 Giugno 2012, Porretta Terme (Bologna). www.sisbq.org. http://www.sisbq.org/uploads/5/6/8/7/5687930/presentazione_stagnaro_it.pdf ; English version: http://www.sisbq.org/uploads/5/6/8/7/5687930/presentazione_stagnaro_eng.pdf

 

19) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, 2009.

 

20) Simone Caramel and Sergio Stagnaro (2012).  Vascular calcification and Inherited Real Risk of lithiasis. Front. In Endocrin. 3:119. doi: 10.3389/fendo.2012.00119

http://www.frontiersin.org/Bone_Research/10.3389/fendo.2012.00119/full [MEDLINE].

 

21) Sergio Stagnaro and Simone Caramel (2013). The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., 67, 683 (June 2013) | doi:10.1038/ejcn.2013.37, http://www.nature.com/ejcn/journal/v67/n6/full/ejcn201337a.html. [MEDLINE].

 

22) Sergio Stagnaro (2013). Two Clinical Evidences Corroborating Microcirculatory Quantum-Biophysical-Semeiotic Theory of Atherosclerosis.  Lectio Magistralis, IV Congress of SISBQ, Porretta Terme (Bologna), 4-5 May, 2013 www.sisbq.org, http://www.sisbq.org/uploads/5/6/8/7/5687930/atherotheory_evidences.pdf

 

23) Sergio Stagnaro and Simone Caramel.  The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.org/Epigenomics_and_Epigenetics/10.3389/fgene.2013.00055/full [MEDLINE]

 

24) Sergio Stagnaro (2013). Two Clinical Evidences corroborating Microcirculatory QBS Theory of Atherosclerosis. Lectio Magistralis, IV Meeting of Quantum Biophysical Semeiotics International Society, May 4-5, 2013, Porretta Terme, Bologna, Auditorium, Hotel Santoli. Journal of QBS, http://www.sisbq.org/uploads/5/6/8/7/5687930/atherotheory_evidences.pdf

 

25) Sergio Stagnaro (2013). Abdominal Aortic Aneurism Inherited Real Risk: Patho-Physiology, Quantum-Biophysical-Semeiotic Symptomatology, Diagnosis and Therapy. www.sisbq.org. Journal of Quantum Biophysical Semeiotics. http://www.sisbq.org/uploads/5/6/8/7/5687930/aaa_irr_lectio_magistralis_2013.pdf

 

26) Sergio Stagnaro, Simone Caramel. Inherited Real Risk of Coronary Artery Disease: pathophysiology, diagnosis and primary prevention. Epidemiology and Cardiovascular Prevention. Brief Communication. 8th International Congress of Cardiology in the internet. Published: 28 October 2013. FAC Federaciòn Argentina de Cardiologia http://fac.org.ar/8cvc/llave/tl054_stagnaro/tl054_stagnaro.php   – PDF

 

27) Sergio Stagnaro. CAD Inherited Real Risk In Preventing Myocardial Infarct. http://www.sci-vox.com, 13 September, 2010.  http://www.sci-vox.com/stories/story/2010-09-13cad+inherited+real+risk+in+preventing++myocardial+infarct..html

 

28) Sergio Stagnaro. Reale Rischio Congenito di Infarto miocardio. Fondamentali Aspetti Teorici, 2014.  www.sisbq.org, http://www.sisbq.org/uploads/5/6/8/7/5687930/rrcima2014_sstagnaro.pdf

 

29) Sergio Stagnaro. Reale Rischio Congenito di Infarto Miocardio, 20014. Diagnosi e Terapia. http://www.sisbq.org/uploads/5/6/8/7/5687930/rrcima2014_sstagnaro.pdf

 

30) Pyatakovich F.A., Stagnaro S.,   Caramel S., Yakunchenko T.I., Makkonen K.F., Moryleva O.N.  Background Millimeter Radiation Influence in Cardiology on patients with metabolic and pre-metabolic  syndrome. Journal of Infrared and Millimeter Waves, , Shanghai, China http://journal.sitp.ac.cn/hwyhmb/hwyhmben/ch/reader/view_abstract.aspx?file_no=120750&flag=131) Simone Caramel (2010). Coronary Artery Disease and Inherited Real Risk of CAD.                     Journal of Quantum Biophysical Semeiotics. http://www.sisbq.org/uploads/5/6/8/7/5687930/cad_caramel.pdf

 

32) Sergio Stagnaro, Simone Caramel. Inherited Real Risk of Coronary Artery Disease: pathophysiology, diagnosis and primary prevention. Epidemiology and Cardiovascular Prevention. Brief Communication. 8th International Congress of Cardiology in the internet. Published: 28 October 2013. FAC Federaciòn Argentina de Cardiologia http://fac.org.ar/8cvc/llave/tl054_stagnaro/tl054_stagnaro.php   – PDF

 

33) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., http://www.nature.com/ejcn/journal/v67/n6/full/ejcn201337a.html [Medline]

34) Simone Caramel, Marco Marchionni                   and Sergio Stagnaro (2014). The Glycocalyx Bedside Evaluation Plays A Central Role in Diagnosing Type 2 Diabetes Mellitus and in its Primary Prevention. Treatment Strategies – Diagnosing Diabetes, Cambridge Research Centre, Volume 6 Issue 1, Pg 41-43. http://viewer.zmags.com/publication/0aafcae9#/0aafcae9/1

35) Mario Siniscalchi, Simone Caramel, Sergio Stagnaro (2016). Quando il fonendoscopio aiuta il cardiologo. Cuore e Vasi. Anno XXXVII • N. 3-4/2015, dicembre. Pg.15.

 

36) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov/pubmed/25743850[MEDLINE]

37) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease  Primary Prevention. Letter to the Editor, The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/article/10.1007/s12603-013-0435-7  [Medline]

38) Sergio Stagnaro and Simone Caramel.  Magnesium Deficiency Clinical Syndrome and Magnesium Therapy in Hypertensives – EJCN European Journal of Clinical Nutrition – Nature Publishing Group  Eur J Clin Nutr. 2012 Jun 27. doi: 10.1038/ejcn.2012.76. [Epub ahead of print] No abstract available. PMID: 22739250 [MEDLINE]

39) Sergio Stagnaro and Simone Caramel.    Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology. Front Endocrinol (Lausanne). 2013; 4: 17. Published online 2013 Feb 26. doi:  10.3389/fendo.2013.00017http://www.frontiersin.org/Review/ReviewForum.aspx  [Medline]

40) Sergio Stagnaro and Simone Caramel.  The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.org/Epigenomics_and_Epigenetics/10.3389/fgene.2013.00055/full  [MEDLINE]

41) Simone Caramel and Sergio Stagnaro (2012).   Vascular calcification and Inherited Real Risk of lithiasis. Front. In Encocrin.  3:119. doi: 10.3389/fendo.2012.00119 http://www.frontiersin.org/Bone_Research/10.3389/fendo.2012.00119/full [MEDLINE]

Regards

Dr Sergio Stagnaro

Sergio Stagnaro MD

Via Erasmo Piaggio 23/8,

16039 Riva Trigoso (Genoa) Italy

Phone 0390-0185-42315

Founder of Quantum Biophysical Semeiotics,

Honorary President of International Society of

Quantum Biophysical Semeiotics (SISBQ)

www.semeioticabiofisica.it

www.sisbq.org

www.sergiostagnaro.wordpress.com

 

Diagnosi Clinica Semeiotico-Biofisico-Quantistica di Appendicite Acuta. Lavoro aggiornato.

All physicians agree with the statement that bedside diagnosing appendicitis in children, especially under 3 years, is still difficult (1, 2, 3). Looking at the cause of delaying acute appendicitis, we recognize the lack of an efficacious clinical tool, which allows a prompt diagnosis, in spite of location of appendix and severity of its inflammation.

In fact, Authors constantly overlook the clinical, auscultatory percussion diagnosis, I made for the first time 30 years ago (2) (For further information,See my site www.semeioticabiofisica.it, Practical Applications), which recently was enriched by numerous signs, gathered at the bed-side by means of the Quantum Biophysical Semeiotics (1-3, 6,8), a method of investigation based chiefly on the old auscultatory percussion, briefly described as follows. Compared with the insufficient reliability of the traditional physical semeiotics (30% of surgical operations are made on healthy appendix), Quantum Biophysical Semeiotics allows doctor to bedside recognize, promptly and easily, appendicitis by mean of a large number of signs, among them the typical Gastric Tonic Contraction (GTC), present in 100% of cases of appendicitis, not considering its location and seriousness, as permits me to state 60 year- long well-established clinical experience (6,7).

In addition, GTC permits rapidly to evaluate the disorder seriousness, as well as therapeutic monitoring, performed also with the aid of other numerous biophysical semeiotic signs, which are “aspecific” – inflammation signs, observed in all diseases, infective, connectival, tumoural in origin – and “specific”, i.e. typical of the appendicitis (1,2,3). Among other numerous signs, due to space limits I remember only the Rethiculo-Endothelial System Hyperfunction Syndrome (RESHS), now known as Monocytes-Macrophages System (2,3), although more specific and sensitive, and Acute Antibody Synthesis Syndrome (AASS) (2), described in detail also in above-cited website. RESHS corresponds to the ESR elevation and to altered proteins electrophoresis, but is of both more sensitive as well as specific (1-7). To detect these signs and syndromes, doctor has to know only the Auscultatory Percussion of the stomach, really easy to be performed.

In order to recognize and “quantitatively” evaluate the GTC Sign doctor invites the patient, lying down in supine position, “to press down its abdomen as to evacuate” (simulated evacuation test; practically patient is invited to carry out Valsalva’s manoeuvre) – Berti-Riboli’s Sign *– or most desirably doctor applies digital pressure precisely upon cutaneous projection area of the inflammed appendix, previously localized by means of auscultatory percussion, immediately (latency time: 1-3 sec.) stomach dilates (i.e., the gastric aspecific reflex suddenly appears), then, after further 3 sec. precisely, stomach contracts rapidly in intense manner: GTC Sign of 2 cm. (3, 6, 7).

In health, the latency time of gastric aspecific reflex is 10 sec., duration > 5 sec. and, finally, GTC < 2cm. In case of retrocaecal appendicitis, until now really difficult to recognize clinically with the aid of the old, traditional, accademic physical semeiotics, the patient bends its stretched right leg towards abdomen: the “spontaneous” GTC rapidl appears (100% of cases), after a gastric aspecific reflex with 1-2 lt and lasting once more 3 sec.: Bella’s Sign** “classic” (Bella’s Sign “variant”: patient bends the left leg in identical manner as described above, with the same results in case of appendix located in left ileo-pelvic region). In health, under identical above-described conditions, i.e., retrocaecal appendix, latency time of gastric aspecific reflex is 10 sec., duration > 5 sec. and GTC intensity is < 2 cm. Interestingly, the degrees of reflexes paramaters are the same in both signs, pointing out internal and external coherence of biophysical semeiotic theory. A well established clinical experience allows me to state that by means of Quantum Biophysical Semeiotics, the diagnosis of appendicitis is clinical as well as very quick, as in case of inherited renal cancer, and overt cancer: “intense” cutaneous pintching, lasting one second, of one esophagous trigger point brings about GTC in case of acute appendicitis! (9, 10).

I have recently opened a new way in the clinical diagnosis, based on the presence of inflammation, even low-grade chronic inflammation – in all disorders, including CVD/CAD, Osteoporosis, T2DM, Cancer, starting from the very initial stages.

Interestingly,  in health, the nail pressure upon appendix trigger points provokes the gastric aspecific reflex after a Latency Time of 10 sec. exactly.

On the contrary, under identical experimental condition, in case of appendicitis, the Latency Times lowers, inversely correlated with the seriousness of desease, thus facilitating its diagnosis.

Unfortunately, nowadays, due to the traditional physical semeiotics, although sophysticated testing of image semeiotics and laboratory, diagnosing appendicitis at the bed-side is still sometimes difficult particularly in children and actually this fact accounts for the reason that patients are too often operated late.

* Dedicated to my friend Prof .Edoardo Berti Riboli , Surgeon at Genoa University

** In Memoriam of my friend Dr. Luigi Bella, General Practitioner, Lavagna (Genoa)

References.

1) Stagnaro S. Bed-side diagnosing acute appendicitis and gastrointestinal diseases. Gut.j.on line: http://gut.bmjjournals.com/cgi/eletters/52/5/770– a#100

2) Stagnaro S., Il Ruolo della Percussione Ascoltata nella “difficile Diagnosi” di Appendicite. Biol. Med. 8, 71, 1986.

3)Stagnaro-Neri M., Stagnaro S., Appendicite. Min. Med. 87, 183, 1996 [Medline]

4) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004.   http://www.travelfactory.it/semeiotica_biofisica.htm

5) Stagnaro Sergio.Biophysical-Semeiotic Diagnosis of Appendicitis. 14 aprile 2009, at URL  http://sciphu.com,  and at URL http://wwwshiphusemeioticscom-stagnaro.blogspot.com/

6) Sergio Stagnaro. Biophysical-Semeiotics Diagnosis of Appendicitis. www.bmj.com ; 2 September, 2002  http://www.bmj.com/cgi/eletters/325/7363/505#25361

7) Sergio Stagnaro. Quantum-Biophysical-Semeiotic Bedside Diagnosis of Appendicitis. www.fce.it, 18 giugno 2010. http://www.fceonline.it/images/docs/appendicitis.pdf

8) Sergio Stagnaro.(2015) Il Segno di Di Perri. Diagnosi clinica SBQ endocrinologica di appendicite: attivazione microcircolatoria nel centro neuronale del GH-RH. www.sisbq.org; http://www.sisbq.org/ultimissime.html

My overlooked clinical war against the Five Stages of Type 2 Diabetes Mellitus.

Three years ago, I published the following comment (here in its complete version)  on PLOS website.

Until  physicians will ignore Quantum Biophysical Semeiotics, T2DM epidemic continues.

http://currents.plos.org/genomictests/article/genetic-risk-profiling-for-prediction-20113liwenx5c-9/

sergio stagnaro

May 2, 2011

Gene Mutations parallel Biological Alterations: The New War against Five Stages of type 2 Diabetes Mellitus.

Dear Friends,

first of all, I emphasise here once again that gene mutations bring about necessarily modifications of biological functions, bedside assessed in a reliable manner, as I have demonstrated earlier (Stagnaro Sergio. Biological System Functional Modification parallels Gene Mutation. http://www.Nature.com, March 13, 2008,http://blogs.nature.com/nm/spoonful/2008/03/gout_gene.html).

Secondly, according to WHO competent Authorities, there were in 2010 250 milion of diabetics, and they will be 366 milion in 2030, indicating that type 2 DM is today’s growing epidemics (1-15).

In my opinion, as far as diabetes is concerned, pre-primary (analogously to the Manuel’s Story, http://www.sisbq.org/qbs-magazine.html), as well as primary prevention, especially when initiated in the first two stages among the five of the natural history of the disease, is far better than therapy, as usually.

Unfortunately, Diabetic “and” Dislipidemic Constitutions, conditio sine qua non of type 2 DM, are nowadays unfortunately overlooked by the majority of physicians all around the world (12-14). A long well established clinical experience allows me to state that with the aid of Quantum Biophysical Semeiotics, physicians can quickly and easili bedside recognize the “microcirculatory remodelling”, based on newborn-pathological, subtype a) oncological , and b), aspecific, type I, Endoarteriolar Blocking Devices in tissue, wherein does really exist the inherited real risk of human common and severe diseases, as diabetes (12-15).

Obviously that happens in individuals with defined Biophysical Semeiotics Constitutions, in our case, Diabetic “and” Dislipidaemic, according to Josslin (1-6, 12-15). To realize on vast scale Diabetes both Pre-Primary, and Primary Prevention (PP), enrolling exclusively individuals at type 2 DM Inherited Real Risk, we need new clinical tools, aiming to lower the increasing number of patients, because the present, expensive screening has failed (14). For instance, in the normal Langheran’s islets microcirculatory bed, there are exclusively “normal” type II (= in arterioles, according to Hammersen), but not type I (= in small arterioles) endoarteriolar blocking devices, i.e. EBD, of first and second classes, according to S.B.Curri (See http://www.semeioticabiofisica.it/microangiologia).

In health, i.e., not involved by Diabetic Constitution, we cannot observe type I, newborn- pathological, EBD in above-mentioned biological system. On the contrary, in individuals involved by diabetic constitution as well as diabetic “Inherited Real Risk” and overt diabetes, of course, we observe with the aid of Quantum Biophysical Semeiotics also type I, newborn-pathological, subtype b) a-specific , EBD, facilitating the diagnosis and consequently diabetes primary prevention. In addition, the evaluation of Insulin Secretion Acute Pick Renal Test is significantly impaired, corroborating the clinical diagnosis (1-3) (See above cited- website, Practical Applications, and Glossary).

Finally, an interesting clinical tool in recognizing diabetic constitution-dependent inherited real risk, as well as in diagnosing diabetes since early stages and diabetic monitoring proved to be bedside Biophysical-Semeiotic Osteocalcin Test and Siniscalchi’s Sign (10, 15). As a matter of fact, Pre-hypertension during Young Adulthood may be involved by Coronary Calcium Later in Life exclusively in presence of Inherited Real Risk of CAD, typical for individuals with lithyasic Constitution, present in about 50% OF ALL CASES OF Pre-Metabolic and Metabolic Syndrome (www.semeioticabiofisica.it; Constitutions and Bibliography).

Considering the frequent association between hypertension and diabetes, more important, in my opinion based on 53-year-long clinical experience, is bedside recognizing diabetic predisposition, now-a-days possible since birth, utilising a lot of methods, different in difficulty, but all reliable. For the first time, from the clinical view-point, I have recently illustrated an original manoeuvre, based on a singular activity of osteocalcin, and reliable in bedside detecting diabetes in one minute, with the aid of a stethoscope (10).

In fact, osteocalcin, a product of osteoblasts, among other action mechanisms, stimulates both insulin secretion and insulin receptor sensitivity. As a consequence, osteocalcin, secreted by above-mentioned bone cells during mean-intense lasting digital pressure – for instance – applied upon lumbar vertebrae, brings about increasing pancreatic diameters, i.e., technically speaking, type I, associated, Langherans’s islet microcirculatory activation, so that doctors assess pancreas size augmentation, which in health, lasts 10 seconds exactly (1-11). After that, pancreas diameters return to basal value for 3 sec. The second pancreas size increasing lasts 20 sec., and finally the third show the highest value: 30 sec. I terme such a clinical investigation.

On the contrary, in case of diabetic constitution (3, 4, 11, 13, 27) the first pancreas increasing persists normally (10 sec.), but both the second and the third are less than physiological ones (i.e., less than 20 sec. and respectively 30 sec.). In presence of intense inherited real risk of diabetes (6), such as impairment is greater. Finally, in case of diabetes the alteration is present already in the first evaluation, wherein duration appears less than 10 sec., inversely related with disorder seriousness. Subsequently, I have ascertained that such a Manoeuvre result pathological already in individuals involved by both Diabetic Constitution and Inherited Diabetic Real Risk (1-11). Interestingly, not only in examining subject, but also in all others, even if kilometers way from him (her), according to Lory’s experiment, based of no local realm in biological systems (12, 15), pancreas show identical modifications, allowing doctors to made clinical diagnosis until now impossible (1-15).

 

References

1)Stagnaro S., Stagnaro-Neri M. Valutazione percusso-ascoltatoria del Diabete Mellito. Aspetti teorici e pratici. Epat. 32, 131, 1986

2) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm

3) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico- Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004. http://www.travelfactory.it/libro_costituzionisemeiotiche.htm

4) Stagnaro S., Stagnaro-Neri M. Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory, Roma, 2005. http://www.travelfactory.it/libro_singlepatientbased.htm

5) Stagnaro S. Pivotal role of Biophysical Semeiotic Constitutions in Primary Prevention. Cardiovascular Diabetology, 2:1, 2003 http://www.cardiab.com/content/2/1/13/comments#5753

6) Stagnaro S. Stagnaro Sergio. Newborn-pathological Endoarteriolar Blocking Devices in Diabetic and Dislipidaemic Constitution and Diabetes Primary Prevention. http://www.fce.it, http://www.fceonline.it/index.php?option=com_content&task=view&id=3736&Itemid=47

7) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [MEDLINE]

8) Stagnaro Sergio. New bedside way in Reducing mortality in diabetic men and women. Ann. Int. Med.2007. http://www.annals.org/cgi/eletters/0000605- 200708070-00167v1

9) Stagnaro Sergio. Single Patient Based Medicine: its paramount role in Future Medicine. Public Library of Science. http://medicine.plosjournals.org/perlserv/?request=read-response 2005

10) Stagnaro Sergio. Teoria Patogenetica Unificata, 2006, Ed. Travel Factory, Roma.

11) Stagnaro Sergio. Il test Semeiotico-Biofisico della Osteocalcina nella prevenzione primaria del diabete mellito. http://www.fce.it, http://www.fcenews.it/index.php?option=com_content&task=view&id=909&Itemid=47

12) Stagnaro Sergio e Paolo Manzelli. L’Esperimento di Lory. Scienza e Conoscenza, N° 23, 13 Marzo 2008. http://www.scienzaeconoscenza.it//articolo.php?id=17775

13) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, http://www.travelfactory.it, Roma, Luglio 2009.

14) . Sergio Stagnaro.   New Renaissance in Medicina. Prevenzione Primaria del Diabete Mellito tipo 2. Sito del Convegno, http://qbsemeiotics.weebly.com/atti-del-convegno.html, 16 novembre 2010; http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/report_stagnaro.pdf

15) Sergio Stagnaro.     Siniscalchi’s Sign. Bedside Recognizing, in one Second, Diabetic Constitution, its Inherited Real Risk, and Type 2 Diabetes Mellitus.

24 December, 2010, http://www.scivox.com,   http://www.sci-vox.com/stories/story/2010-12-25siniscalchi%27signi.bedside++diagnosing+type+2+dm.html;  www.sciphu.com; http://wwwshiphusemeioticscom-stagnaro.blogspot.com/

26) Sergio Stagnaro and Simone Caramel (2013).    Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology. [MEDLINE] In press.

27) Sergio Stagnaro and Simone Caramel (2013). The Role of Modified Mediterranean Diet and Quantum Therapy in Type 2 Diabetes Mellitus Primary Prevention. LifeScienceGlobal February 2013, Journal of Pharmacy and Nutrition Sciences, 2013, 3,  http://www.lifescienceglobal.com/home/cart?view=product&id=376

Interstiziologia: possiamo sconfiggere senza spesa l’epidemia diabetica in continuo aumento.

“Per istruire un complotto occorre intelligenza.

In questa inquinata valle di lacrime l’intelligenza è latitante “.

Anonimo ligure del XX secolo.

Il Diabete Mellito tipo 2, T2DM, non colpisce tutti gli individui, evidentemente, ma solo una limitata parte della popolazione mondiale, che necessariamente è caratterizzata da mutazioni genetiche nel mit-DNA e n-DNA, oggi solo in parte conosciute. Infatti, come i topi,  gli esseri umani non sono nati tutti uguali (Stagnaro Sergio.  Not all mice are created equal! BioMedCentral Physiology, 3 December, 2009. http://www.biomedcentral.com/1472-6793/9/21/comments#384660).

Per essere significative, le mutazioni genetiche devono causare alterazioni funzionali in ben definiti sistemi biologici (Stagnaro Sergio. Biological System Functional Modification parallels Gene Mutation. www.Nature.com, March 13, 2008,http://blogs.nature.com/nm/spoonful/2008/03/gout_gene.html).

Il Medico, esperto in Semeiotica Biofisica Quantistica, è capace di valutare bedside, cioè usando  un comune fonendoscopio, in modo quantitativo, le varie attività funzionali dei sistemi biologici, www.sisbq.org e www.semeioticabiofisica.it.

Dopo questa doverosa premessa, leggiamo la seguente mail, a cui finora non ha fatto seguito alcuna risposta da parte dei destinatari:

Messaggio Inoltrato

Oggetto:	T2DM may involve exclusively individuals with Diabetic Constitution.
Data:	Thu, 22 Jan 2015 14:20:52 +0100
Mittente:	Sergio Stagnaro <dottsergio@semeioticabiofisica.it>
A:	varsha.vimalananda@va.gov; Diabetologia Editors <diabetologia-j@bristol.ac.uk>
CC:	Simone Mailing Group <sisbq_medicaldoctors@yahoogroups.com>, Ann Int Med Editors <annp@mail.acponline.org>

Sirs,

after reading the refined paper Night-shift work and incident diabetes among African-American women,  Varsha G. Vimalananda & Julie R. Palmer & Hanna Gerlovin, et al., in Diabetologia current issue, Diabetologia  DOI 10.1007/s00125-014-3480-9, I am really surprised  that in 2015 still exist Publishers, Editors, and Authors who apparently ignore the Diabetic Constitution  and its Inherited Real Risk, conditio sine qua non of the onset of T2DM.

I find distressing the “conclusions/interpretation. Long duration of shift work was  associated with an increased risk of type 2 diabetes. The association was only partially explained by lifestyle factors  and BMI. A better understanding of the mechanisms by which   shift work may affect the risk of diabetes is needed in view of  the high prevalence of shift work among workers in the USA”.

In my opinion, this article is illuminating only because it underlines what accounts for the reason of diabetic epidemic: overlooking Diabetic Constitution and its dependent Inherited Real Risk,  the present epidemic will continue to grow.

Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [MEDLINE];

Stagnaro S., Singh RB. Influence Of  Nutrition On Pre-Metabolic Syndrome And Vascular Variability Syndrome. Editorial, The Open Nutrition Journal. Bentham Sci. Publish. Nutraceuticals Journal, 2009, Volume 2, http://www.benthamscience.com/open/tonutraj/articles/V002/118TONUTRAJ.pdf,

Sergio Stagnaro and Simone Caramel.    Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology. Front Endocrinol (Lausanne). 2013; 4: 17. Published online Feb 26, 2013. doi:  10.3389/fendo.2013.00017. http://www.frontiersin.org/Review/ReviewForum.aspx;  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581808/ [MEDLINE];

Stagnaro-Neri M., Stagnaro S., Sindrome di Reaven, classica e variante, in evoluzione diabetica. Il ruolo della Carnitina nella prevenzione del diabete mellito. Il Cuore. 6, 617, 1993 [MEDLINE];

Regards

Sergio Stagnaro MD
www.sisbq.org
www.semeioticabiofisica.it

A mio parere, è assai preoccupante l’ennesimo, imbarazzato, sospetto silenzio di eccellenti Autori ed Editori di fronte alle mie critiche-costruttive, finalizzate a fermare, senza alcuna spesa a carico dei vari SSN, l’epidemia diabetica, che continua ad aumentare per generale ammissione.

Se nessuna terapia odierna può “guarire” il T2DM, allora perché non cambiamo paradigmi e ci rivolgiamo anche alla Prevenzione Pre-Primaria e Primaria? V. la mia Relazione al prossimo convegno internazionale a Borgario Torinese, il 6 febbraio pv. Locandina   http://amoreuniverso.it/it/8%C2%B0+CONVEGNO+INTERNAZIONALE

A mia conoscenza, nessun esperto in Diabetologia ha fino a questo momento affermato che non tutti gli individui possono ammalare di T2DM, lasciando così intendere che tutti possono essere colpiti da questa patologia, come dimostra il fatto che viene sottoposto a “glicemia” il Pz. che si presenta al PS, indipendentemente dalla fenomenologia clinica lamentata, nel rispetto rigoroso delle Linee Guida.

Il fatto è ancor più sconcertante, e paradossale insieme, se consideriamo il numero di mutazioni genetiche alla base dell’insorgenza del T2DM,  diffuse trionfalmente dai media, frutto del lavoro di geniali Scienziati in famosi Laboratori di Genetica Molecolare. Queste mutazioni genetiche non colpiscono tutti gli individui, ovviamente!

Gli Editori, i Revisori, gli Autori delle numerosissime riviste specializzate ignorano i Cinque Stadi del T2DM, su cui è fondata la mia lotta al Diabete mellito mediante la Prevenzione Pre-Primaria e Primaria, che nessuna autorità competente, ignorando la Semeiotica Biofisica Quantistica, ha potuto finora falsificare.

A partire dalla nascita, a causa del rimodellamento microcircolatorio nelle Isole di Langherans, caratteristico del Reale Rischio Congenito, Dipendente dalla Costituzione Diabetica, come ho spiegato nei precedenti articoli dedicati alla illustrazione dell’Interstiziologia, in rete in LA VOCE di SS., l’interstizio locale è aumentato di volume.

Ne consegue che la pressione digitale lieve/moderata, applicata sui trigger-points pancreatici, provoca il riflesso gastrico aspecifico, statisticamente significativo, assente nel 100% dei soggetti normale, non predisposti al T2DM, permettendo tempestivamente di dividere la popolazione in due parti, nei confronti della predisposizione al dismetabolismo glicidico.

A questo punto, la non costosa Terapia Quantistica, prontamente instaurata,  cancella la Costituzione Diabetica e poi il suo Reale Rischio Congenito.

Ignorare quanto sopra da parte delle competenti autorità sanitarie è sospetto, per usare un eufemismo.

To be continued…