Screening for Lung Cancer With Low-Dose Computed Tomography: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendation FREE
Baserga’sign, described in earlier article (1), proved to be useful in bed-side recognizing iron-deficiency syndrome. In fact, due to iron deficiency, erythropoietin can not stimulate bone-marrow, as it happens in healthy subject, provoking Baserga’s sign. In a few words, in a individual, lying down in supine position, psycho-physically relaxed with open eys to lower melatonin secretion, mean-intense, digital pressure applied upon middle line of sternal body, brings about gastric aspecific reflex after a latency time of exact 10 sec., indicating that bone-marrow activity is normal.
On the contrary, after stimulation of renal erythropoietin secretion by pinching for 15 sec. lateral abdominal skin, the second evaluation of sternal-gastric aspecific reflex shows a statistically lowered latency time: 6 sec., due to bone-marrow increased activity.
Interestingly, exclusively in presence of normal iron tissue level, endogenous erythropoietin is efficient. In fact, in iron deficiency syndrome, the lowering of sternum-gastric aspecific reflex, i.e., Retyculo-Endothelial System Hyperfunction Syndrome (RESH) (2-7), is clearly compromised, in inverse relation to the seriousness of underlying iron deficiency.
In lung cancer (e.g. adenocarcinoma), one of us has observed a “variant” form of the Baserga’sign. Really, he suspected that stimulating cutaneous trigger-points, related to lung cancer even in the initial stage of Lung Cancer, i.e., Inherited Real Risk (1-6) by digital pressure, could provoke the output of tumour cell products, which in turn stimulate bone-marrow, at the moment partially suppressed in its function. According to Max Borne, a new theory must be “mad” enough to be true.
In healthy, mean-intense digital pressure, applied on skin projection area of diverse lung lobes (= stimulation of pulmonary trigger-points), brings about gastric aspecific reflex after exactly 8 sec. latency time (lt), and the basal latency time of Rethiculo-Endothelial System Hyperfunction Syndrome (2-6) lasts identical (NN=10 sec.), under the same condition, when the stimulation of lung trigger-points lasts about 15 sec. In fact, the latency time of sternum-aspecific gastric reflex, i.e., RESH (= mean-intense digital pressure applied upon the middle line of sternal body, and/or iliac crests) persists identical to the basal one: lt 10 sec., also after stimulating the trigger-points of healthy lung for about 15 sec., indicating absence of erytropoietin-like substance secretion from lung (or whatever biological system, of course).
On the contrary, in case of lung cancer Inherited Real Risk (3-7) and overt lung cancer, under the same condition (= mean-intense digital pressure, applied precisely on disorder cutaneous projection area, lasting 15 sec.), one observes a significant reduction of RESH lt, lowering from 10 sec. to 6 sec., in relation to underlying disorder seriusness.
In addition, in presence of lung cancer Inherited Real Risk, characterized by the presence of newborn-pathological, type I, subtype a), Endoarteriolar Blocking Devices (3- 7), interestingly, basal lt. of lung-aspecific gastric reflex may result normal (i.e., 8 sec.), but reflex duration is pathologically more than 4 sec. (NN =lower than 4 sec.: parameter value of paramount diagnostic importance, correlated with local Microcirculatory Functional Reserve), and finally follows the pathological tonic Gastric Contraction, absent under physiological conditions, and thus typical of oncological disease.
In presence of overt lung cancer, even in initial stage, latency time of lung-gastric aspecific reflex lowers significantly (NN = 8 sec.), reflex duration is incresead (more than 4 sec.), followed, without delay, by pathological tonic Gastric Contraction (tGC)
Finally, due to the non-local reality in biological systems, in healthy, the intense digital pressure applied on any point of the chest does not cause simultaneously the gastric aspecific reflex. On the contrary, in lung cancer, from its inherited real risk, in the same experimental conditions, the doctor observes a gastric aspecific reflex followed by tonic gastric contraction (7).
2) Stagnaro S. Segno di Baserga: diagnosi clinica semeiotico-biofisica della carenza di ferro mediante valutazione dell’attività midollare dell’eritropoietina endogena. URL: http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/Segno%20Baserga%20variant%20engl.doc
3) Stagnaro Sergio. Bedside Recognizing Lung Cancer Inherited Real Risk rather than IL-12 treatment. www.plosone.org, 2 July, 2009. http://www.plosone.org/annotation/listThread.action?inReplyTo=info:doi/10.1371/annotation/019871da-ef04-426b-8071-98e4d6e16c54&root=info:doi/10.1371/annotation/019871da-ef04-426b-8071-98e4d6e16c54