Semeiotica Biofisica Quantistica. Il Nuovo Rinascimento della Medicina.

Articoli con tag ‘Quantum Biophysical Semeiotic’

Rossana’s Manoeuvre in bedside ascertaining disorders, oncological in nature.

The topic of this fascinating article is really interesting particularly for the general practitioners, so that I like to underline the following original, clinical information.

I have discovered and described in previous papers how our brain sensor, i.e. PNEI system and Limbic area, including Hippocampus, react to every, even minimal, insult, aiming to damage or to destroy body health, independent of its nature, as both clinical and experimental evidences demonstrate.

In a few words, at Christmas 2011, from womb of Quantum Biophysical Semeiotics ( has born a new clinical diagnostic method, I have termed Brain Sensor Bedside Evaluation (BSBE), which opened a new road in the field of physical Semeiotics (1). Physycians have to utilise in daily practice the present knowledge on cerebral cortex functions, as it has recently happened, regarding PNEI system and Limbic region, i.e. Brain Sensor Bedside Evaluation.

In following I briefly illustrate the Rossana’s Manoeuvre, reliable in bedside recognizing from the birth, i.e., from Oncological Terrain-Dependent, Inherited Real Risk, lesion oncological in nature. Interestingly, such a clinical method allows physicians to bedside diagnose, easily and quickly, the presence of the heritable, through maternal mitochondria, predisposition to cancer, locating it precisely with a stethoscope, staging it and fortunately removing it by inexpensive Reconstructing Mitochondrial Quantum Therapy (2-4).

In health, at rest, Hippocampus microcirculatory flow-motion shows wall physiological movements: the diastole of Peripheral Heart, according to Allegra (5), namely, small arteries and arterioles, according to Hammersen, lasts 6 sec. (= vasomotility), paralleling the duration of vasomotion of the local nutritional capillaries: type I, physiological, Associated Microcirculation.

As a consequence, the Latency Time of Brain Sensor-Aspecific Gastric Reflex is 8 sec., Duration is physiological: < 3 sec. – 4 sec. <

On the contrary, in individual involved by any oncological disorder, starting from birth, i.e., from the Oncological Terrain-Dependent, Inherited Real Risk, Hippocampus microcirculation appears activated, of Type 2, dissociated, characterized by prolonged Duration of the only vasomotility, aimed at maintaining innormal range the vasomotion (= 6 sec.). The intensity of these parameter values parallels the seriousness of underlying disorder.

Thus, under pathological disorders, oncological in nature, Latency Time of Brain Sensor-Aspecific Gastric Reflex is normal, i.e., 8 sec. in the Oncological Terrain-Dependent, Inherited Real Risk of cancer, but Duration is 4 sec. or more.

In presence of overt malignancy, Latency Time of the referred Reflex lowers, in inverse correlation with the seriousnss odf cancer.

Interestingly, in the overt tumour, intense digital pressure (1,000 dyne/cm2), applied directly either on lesion or on its trigger-pint, brings about simultaneously further Microcirculatory Activation in the Hippocampus, doubling the basal duration of the Latency Time of Hippocampus-Gastric Aspecific Reflex, a value more easy to be evaluated by physicians.

On the contrary, in the first stages of cancer, the above reflex pathological events show a less intensity and a delay in the onset after the stimulation, above referred. Latency Time ranging from 2 to 10 sec., in inverse relation to the stage of the disease.

The above results are corroborated by Moncada’s Manoeuvre , Cris Manoeuvre, and Burigana Manoeuvre (6-10).

At this point, I would like to emphasise that the multiple functions of the cerebellum, can now be carefully evaluated at the bedside with a common stethoscope, according to Clinical Microangiology (5).

Some years ago, I have suggested the possible existence of a close relationship between the cerebellum and future cerebral atherosclerosis, demonstrating it in clinical research, performed with the essential psychokinetic diagnostics (1-3). Such a intuition proved to be correct, since the cerebellum is a sensor of future cerebral degenerative vascular disease, as Senile Dementia, Parkinson Disease, Alzheimer Disease, a.s.o.

Briefly said, I started a clinical research aimed to recognize the possible Inherited Real Risk of all Brain Degenerative Diseases. It is impossible to summerize this complex method. However, the following experimental evidence highlight what I mean.

In health, the simple thinking   of rotating the head is accompanied by microcirculatory activation, type I, associated, physiological, in the cerebellum middle anterior area.

In contrast, in patients involved by overt brain atherosclerosis, between the “thinking” of rotate the head and the cerebellar microcirculatory activation there is a latency time of 3 – 4 seconds, because of the local microcirculatory remodeling, typical of the Inherited Real Risk, removed by inexpensive therapy (4).



1) Sergio Stagnaro and Simone Caramel (2012) New ways in physical Diagnostics: Brain Sensor Bedside Evaluation. The Gandolfo’s Sign. January, 2012. Journal of Quantum Biophysical Semeiotics.

2) Sergio Stagnaro. Il Cervelletto è un Sensore della Predisposizione all’Aterosclerosi Cerebrale. La Manovra di De Lisi.,

3) Sergio Stagnaro and Simone Caramel. BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention. Front. Genet. | doi: 10.3389/fgene.2013.00039. [MEDLINE]

4) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675.

5) Sergio Stagnaro – Marina Neri Stagnaro. Microangiologia Clinica. A cura di Simone Caramel. e-book,, 1)

6) Sergio Stagnaro. Manovra di Moncada*: Diagnosi Differenziale tra Lesione Benigna e Maligna in 15 secondi.

7) Sergio Stagnaro. Manovra di Moncada. Ruolo Fisiopatologico Centrale dell’Acidosi Istangica.;

8) Sergio Stagnaro. Manovra di Cris. ottobre 18, 2018 di dabpensiero.

9) Sergio Stagnaro (2019. Ruolo diagnostico centrale della Manovra di Burigana nella Connettomologia Clinica SBQ, neuromale e non-neuronale.;

10) Sergio Stagnaro (2019). Ordine Implicato  e  Ordine Esplicato nella Manovra di Burigana. La Natura delle Oscillazioni fisiologiche del Tempo d Latenza tra 3 e  5 sec. evidenziano la Coerenza interna ed esterna della Semeiotica Biofisica Quantistica.


Se il National Cancer Institute non si aggiorna, l’epidemia cancro continuerà ad aumentare!

Stiamo vivendo l’Era dei Lumi Spenti anche nella Medicina, Serva dell’Economia. Purtroppo, non prevedo la loro riaccensione in un prossimo futuro.

Di seguito il commento critico inviato al National Cancer Institute con l’invito ad aggiornarsi. Il commento è stato regolarmente ricevuto:

National Cancer Institute.

Thank you for your message to the National Cancer Institute (NCI). If your email requires a response, you should expect it within 2 – 4 business days.  If you live in the United States and need information sooner, please call the NCI’s Cancer Information Service (CIS) at 1-800-4-CANCER (1-800-422-6237), 8 a.m. to 8 p.m. Eastern Time, Monday through Friday.

Di seguito il titolo e il testo del messaggio:

Physical Exercise and Cancer Incidence: Up-date it

I invite you kindly to learn Oncological Terrain-Dependent, Inherited Real Risk of cancer, conditio sine qua non cancer onset! Without such a predisposition to malignancy, bedside diagnosed  from birth with a stethoscope, eliminated with inexpensive Restructuring Mitochondrial Quantum Therapy, and based as all other Constitutions, on a mitochondrial cytopathy, I have discovered 36 year ago and termed Congenital Acidosic Enzyme-Metabolic Histangiopatyhy (CAEMH), all environmental risk fatoctors, including diet, physical movement, tobacco smokin, a.s.o., are innocent bystanders (1-7).    As far as physicians all around the world ignore Clinical Miroangiology fundamental concepts, particularly the I, II and III type of  Microcirculatory Activation, cancer will continue to be a growing epidemic, and the real relation between physical excercise and cancer incidence will be unavoidably a mystery.
1) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. X Congr. Naz. Soc. It. di Microangiologia e Microcircolazione. Atti, 61. 6-7 Novembre, 1981,  Università Le Scotte, Siena.
2) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica condizione necessaria non sufficiente della oncogenesi. XI Congr. Naz. Soc. It. di Microangiologia e Microcircolaz. Abstracts, pg 38, 28 Settembre-1 Ottobre,  1982, Bellagio,
3) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. Gazz Med. It. – Asch. Sci, Med. 144, 423, 1985.
4) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004.
5) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675.
6) Sergio Stagnaro and Simone Caramel.  BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention.  Front. Genet. | doi: 10.3389/fgene.2013.00039. [MEDLINE]
7) Sergio Stagnaro and Simone Caramel. The Role of Modified Mediterranean Diet and Quantum Therapy in Oncological Primary Prevention.  Bentham PG.,Current Nutrition & Food Science  ISSN (Print): 1573-4013;  ISSN (Online): 2212-3881. VOLUME: 9,  ISSUE: 1; DOI: 10.2174/1573401311309010011;

To be continued

Diagnosi Clinica Semeiotico-Biofisico-Quantistica di Appendicite Acuta. Lavoro aggiornato.

All physicians agree with the statement that bedside diagnosing appendicitis in children, especially under 3 years, is still difficult (1, 2, 3). Looking at the cause of delaying acute appendicitis, we recognize the lack of an efficacious clinical tool, which allows a prompt diagnosis, in spite of location of appendix and severity of its inflammation.

In fact, Authors constantly overlook the clinical, auscultatory percussion diagnosis, I made for the first time 30 years ago (2) (For further information,See my site, Practical Applications), which recently was enriched by numerous signs, gathered at the bed-side by means of the Quantum Biophysical Semeiotics (1-3, 6,8), a method of investigation based chiefly on the old auscultatory percussion, briefly described as follows. Compared with the insufficient reliability of the traditional physical semeiotics (30% of surgical operations are made on healthy appendix), Quantum Biophysical Semeiotics allows doctor to bedside recognize, promptly and easily, appendicitis by mean of a large number of signs, among them the typical Gastric Tonic Contraction (GTC), present in 100% of cases of appendicitis, not considering its location and seriousness, as permits me to state 60 year- long well-established clinical experience (6,7).

In addition, GTC permits rapidly to evaluate the disorder seriousness, as well as therapeutic monitoring, performed also with the aid of other numerous biophysical semeiotic signs, which are “aspecific” – inflammation signs, observed in all diseases, infective, connectival, tumoural in origin – and “specific”, i.e. typical of the appendicitis (1,2,3). Among other numerous signs, due to space limits I remember only the Rethiculo-Endothelial System Hyperfunction Syndrome (RESHS), now known as Monocytes-Macrophages System (2,3), although more specific and sensitive, and Acute Antibody Synthesis Syndrome (AASS) (2), described in detail also in above-cited website. RESHS corresponds to the ESR elevation and to altered proteins electrophoresis, but is of both more sensitive as well as specific (1-7). To detect these signs and syndromes, doctor has to know only the Auscultatory Percussion of the stomach, really easy to be performed.

In order to recognize and “quantitatively” evaluate the GTC Sign doctor invites the patient, lying down in supine position, “to press down its abdomen as to evacuate” (simulated evacuation test; practically patient is invited to carry out Valsalva’s manoeuvre) – Berti-Riboli’s Sign *– or most desirably doctor applies digital pressure precisely upon cutaneous projection area of the inflammed appendix, previously localized by means of auscultatory percussion, immediately (latency time: 1-3 sec.) stomach dilates (i.e., the gastric aspecific reflex suddenly appears), then, after further 3 sec. precisely, stomach contracts rapidly in intense manner: GTC Sign of 2 cm. (3, 6, 7).

In health, the latency time of gastric aspecific reflex is 10 sec., duration > 5 sec. and, finally, GTC < 2cm. In case of retrocaecal appendicitis, until now really difficult to recognize clinically with the aid of the old, traditional, accademic physical semeiotics, the patient bends its stretched right leg towards abdomen: the “spontaneous” GTC rapidl appears (100% of cases), after a gastric aspecific reflex with 1-2 lt and lasting once more 3 sec.: Bella’s Sign** “classic” (Bella’s Sign “variant”: patient bends the left leg in identical manner as described above, with the same results in case of appendix located in left ileo-pelvic region). In health, under identical above-described conditions, i.e., retrocaecal appendix, latency time of gastric aspecific reflex is 10 sec., duration > 5 sec. and GTC intensity is < 2 cm. Interestingly, the degrees of reflexes paramaters are the same in both signs, pointing out internal and external coherence of biophysical semeiotic theory. A well established clinical experience allows me to state that by means of Quantum Biophysical Semeiotics, the diagnosis of appendicitis is clinical as well as very quick, as in case of inherited renal cancer, and overt cancer: “intense” cutaneous pintching, lasting one second, of one esophagous trigger point brings about GTC in case of acute appendicitis! (9, 10).

I have recently opened a new way in the clinical diagnosis, based on the presence of inflammation, even low-grade chronic inflammation – in all disorders, including CVD/CAD, Osteoporosis, T2DM, Cancer, starting from the very initial stages.

Interestingly,  in health, the nail pressure upon appendix trigger points provokes the gastric aspecific reflex after a Latency Time of 10 sec. exactly.

On the contrary, under identical experimental condition, in case of appendicitis, the Latency Times lowers, inversely correlated with the seriousness of desease, thus facilitating its diagnosis.

Unfortunately, nowadays, due to the traditional physical semeiotics, although sophysticated testing of image semeiotics and laboratory, diagnosing appendicitis at the bed-side is still sometimes difficult particularly in children and actually this fact accounts for the reason that patients are too often operated late.

* Dedicated to my friend Prof .Edoardo Berti Riboli , Surgeon at Genoa University

** In Memoriam of my friend Dr. Luigi Bella, General Practitioner, Lavagna (Genoa)


1) Stagnaro S. Bed-side diagnosing acute appendicitis and gastrointestinal diseases. Gut.j.on line:– a#100

2) Stagnaro S., Il Ruolo della Percussione Ascoltata nella “difficile Diagnosi” di Appendicite. Biol. Med. 8, 71, 1986.

3)Stagnaro-Neri M., Stagnaro S., Appendicite. Min. Med. 87, 183, 1996 [Medline]

4) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004.

5) Stagnaro Sergio.Biophysical-Semeiotic Diagnosis of Appendicitis. 14 aprile 2009, at URL,  and at URL

6) Sergio Stagnaro. Biophysical-Semeiotics Diagnosis of Appendicitis. ; 2 September, 2002

7) Sergio Stagnaro. Quantum-Biophysical-Semeiotic Bedside Diagnosis of Appendicitis., 18 giugno 2010.

8) Sergio Stagnaro.(2015) Il Segno di Di Perri. Diagnosi clinica SBQ endocrinologica di appendicite: attivazione microcircolatoria nel centro neuronale del GH-RH.;

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