Semeiotica Biofisica Quantistica. Il Nuovo Rinascimento della Medicina.

Articoli con tag ‘Low grade chronic inflammation’

Low Grade Chronic Inflammation: da Virchow alla Semeiotica Biofisica Quantistica.

A mio parere,  con la morte del Prof.Luigi Di Bella,  i Clinici si sono estinti e i Medici, Dipendenti dal Laboratorio e dal Dipartimento delle Immagini, si dimostrano carenti di creatività scientifica.

La presenza di infiammazione cronica nella sede del cancro – ma anche delle altre patologie croniche degenerative, oggi epidemie in aumento –  è stata da Rudolph Virchow fino ai giorni nostri erroneamente interpretata, con la delirante conseguenza che in “lunghi articoli” pubblicati su “celebri peer-reviews” è suggerito l’uso di antinfiammatori per prevenire il Cancro, la CVD/CAD, etc.

Nel seguente commento ho sintetizzato l’interpretazione microangiologica clinica, semeiotico-biofisico-quantistica, che offre una comprensione completa della patogenesi dell’infiammazione cronica di grado lieve, aprendo la strada ad una originale diagnostica clinica e a nuove misure di Prevenzione Primaria, applicabile su vastissima scala.

Questa interpretazione, clinica,originale e soddisfacente, è corroborata da una sicura esperienza clinica e dall’evidenza sperimentale.

Since 1839 (Rudolph Virchow) till now Authors have been observing inflammation in cancer and in numerous chronic degenerative disorders, without being able to explain the correct pathogenesis, in my opinion. To understand the precise role of low grade chronic inflammation in relation to a flurry of degenerative disorders, different in nature, eg., Cancer Pd, AD, T2DM, CVD/CAD, a.s.o., Authors have to know the Constitution-Dependent, Inherited Real Risks, as I and my Disceples have written previous articles (1-5). As a matter of facts, low grade chronic inflammation is the consequnce of altered microcirculatory blood-flow in the precise site of any Inherited Real Risk, characterized by the presence of newborn-pathological, type I, subtype a) oncological, or b) aspecific, Endoarteriolar Blocking Devices, causing a worsening blood-flow impairment, so that local AVA become permanently less or more open: “blood-flow centralization phenomenon”. The consequence of all this is the increased blood pressure upon endothels of the efferent, venous microvessel site, with local damage to the endothelium, i.e., functional desentdothelization, because endothelium are provided with a few mitochondria. Caused by the endothelial function impairment, one observes the arrest of the white blood cells, physiologically rolling along the healthy endothelium (ICAM-1, V-CAM-1, Selectine, a.s.o.), their passage through endothels, bringing about finally inflammation. Interestingly, physicians can now assess in quantitative way at the bedside the presence of low grade chronic inflammation ina simple way , by mean of cytochine gastric aspecific reflex (5).

In conclusion, the time has come to understand the exact role of low grade chronic inflammation in the pathogenesis of a lot of disorders, today’s growing epidemics, as T2DM, CVD/CAD, Osteoporosis, Cancer. Interestingly, the Inherited Real Risks, bedside promptly diagnosed from birth, with a stethoscope,are eliminated by inexpensive Restructuring Mitochondrial Quantum Therapy (6), that allows us to realize on very large scale the Primary Prevention of above-mentioned diseases, enrolling in a rational manner exclusively predisposed individuals.




1) Simone Caramel and Sergio Stagnaro (2012). Vascular calcification and Inherited Real Risk of lithiasis. Front. In Encocrin. 3:119. doi: 10.3389/fendo.2012.00119 [MEDLINE]

2) Sergio Stagnaro and Simone Caramel (2013). Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology. 26 February 2013 |;

3)Sergio Stagnaro and Simone Caramel. BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention. Front. Genet. | doi: 10.3389/fgene.2013.00039. [MEDLINE]

4) Sergio Stagnaro and Simone Caramel. The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. [MEDLINE]

5) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., European Journal of Clinical Nutrition 67, 683 (June 2013) | doi:10.1038/ejcn.2013.37, [Medline]

6) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675.

To be continued …

Diagnosi Clinica Semeiotico-Biofisico-Quantistica di Appendicite Acuta. Lavoro aggiornato.

All physicians agree with the statement that bedside diagnosing appendicitis in children, especially under 3 years, is still difficult (1, 2, 3). Looking at the cause of delaying acute appendicitis, we recognize the lack of an efficacious clinical tool, which allows a prompt diagnosis, in spite of location of appendix and severity of its inflammation.

In fact, Authors constantly overlook the clinical, auscultatory percussion diagnosis, I made for the first time 30 years ago (2) (For further information,See my site, Practical Applications), which recently was enriched by numerous signs, gathered at the bed-side by means of the Quantum Biophysical Semeiotics (1-3, 6,8), a method of investigation based chiefly on the old auscultatory percussion, briefly described as follows. Compared with the insufficient reliability of the traditional physical semeiotics (30% of surgical operations are made on healthy appendix), Quantum Biophysical Semeiotics allows doctor to bedside recognize, promptly and easily, appendicitis by mean of a large number of signs, among them the typical Gastric Tonic Contraction (GTC), present in 100% of cases of appendicitis, not considering its location and seriousness, as permits me to state 60 year- long well-established clinical experience (6,7).

In addition, GTC permits rapidly to evaluate the disorder seriousness, as well as therapeutic monitoring, performed also with the aid of other numerous biophysical semeiotic signs, which are “aspecific” – inflammation signs, observed in all diseases, infective, connectival, tumoural in origin – and “specific”, i.e. typical of the appendicitis (1,2,3). Among other numerous signs, due to space limits I remember only the Rethiculo-Endothelial System Hyperfunction Syndrome (RESHS), now known as Monocytes-Macrophages System (2,3), although more specific and sensitive, and Acute Antibody Synthesis Syndrome (AASS) (2), described in detail also in above-cited website. RESHS corresponds to the ESR elevation and to altered proteins electrophoresis, but is of both more sensitive as well as specific (1-7). To detect these signs and syndromes, doctor has to know only the Auscultatory Percussion of the stomach, really easy to be performed.

In order to recognize and “quantitatively” evaluate the GTC Sign doctor invites the patient, lying down in supine position, “to press down its abdomen as to evacuate” (simulated evacuation test; practically patient is invited to carry out Valsalva’s manoeuvre) – Berti-Riboli’s Sign *– or most desirably doctor applies digital pressure precisely upon cutaneous projection area of the inflammed appendix, previously localized by means of auscultatory percussion, immediately (latency time: 1-3 sec.) stomach dilates (i.e., the gastric aspecific reflex suddenly appears), then, after further 3 sec. precisely, stomach contracts rapidly in intense manner: GTC Sign of 2 cm. (3, 6, 7).

In health, the latency time of gastric aspecific reflex is 10 sec., duration > 5 sec. and, finally, GTC < 2cm. In case of retrocaecal appendicitis, until now really difficult to recognize clinically with the aid of the old, traditional, accademic physical semeiotics, the patient bends its stretched right leg towards abdomen: the “spontaneous” GTC rapidl appears (100% of cases), after a gastric aspecific reflex with 1-2 lt and lasting once more 3 sec.: Bella’s Sign** “classic” (Bella’s Sign “variant”: patient bends the left leg in identical manner as described above, with the same results in case of appendix located in left ileo-pelvic region). In health, under identical above-described conditions, i.e., retrocaecal appendix, latency time of gastric aspecific reflex is 10 sec., duration > 5 sec. and GTC intensity is < 2 cm. Interestingly, the degrees of reflexes paramaters are the same in both signs, pointing out internal and external coherence of biophysical semeiotic theory. A well established clinical experience allows me to state that by means of Quantum Biophysical Semeiotics, the diagnosis of appendicitis is clinical as well as very quick, as in case of inherited renal cancer, and overt cancer: “intense” cutaneous pintching, lasting one second, of one esophagous trigger point brings about GTC in case of acute appendicitis! (9, 10).

I have recently opened a new way in the clinical diagnosis, based on the presence of inflammation, even low-grade chronic inflammation – in all disorders, including CVD/CAD, Osteoporosis, T2DM, Cancer, starting from the very initial stages.

Interestingly,  in health, the nail pressure upon appendix trigger points provokes the gastric aspecific reflex after a Latency Time of 10 sec. exactly.

On the contrary, under identical experimental condition, in case of appendicitis, the Latency Times lowers, inversely correlated with the seriousness of desease, thus facilitating its diagnosis.

Unfortunately, nowadays, due to the traditional physical semeiotics, although sophysticated testing of image semeiotics and laboratory, diagnosing appendicitis at the bed-side is still sometimes difficult particularly in children and actually this fact accounts for the reason that patients are too often operated late.

* Dedicated to my friend Prof .Edoardo Berti Riboli , Surgeon at Genoa University

** In Memoriam of my friend Dr. Luigi Bella, General Practitioner, Lavagna (Genoa)


1) Stagnaro S. Bed-side diagnosing acute appendicitis and gastrointestinal diseases. Gut.j.on line:– a#100

2) Stagnaro S., Il Ruolo della Percussione Ascoltata nella “difficile Diagnosi” di Appendicite. Biol. Med. 8, 71, 1986.

3)Stagnaro-Neri M., Stagnaro S., Appendicite. Min. Med. 87, 183, 1996 [Medline]

4) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004.

5) Stagnaro Sergio.Biophysical-Semeiotic Diagnosis of Appendicitis. 14 aprile 2009, at URL,  and at URL

6) Sergio Stagnaro. Biophysical-Semeiotics Diagnosis of Appendicitis. ; 2 September, 2002

7) Sergio Stagnaro. Quantum-Biophysical-Semeiotic Bedside Diagnosis of Appendicitis., 18 giugno 2010.

8) Sergio Stagnaro.(2015) Il Segno di Di Perri. Diagnosi clinica SBQ endocrinologica di appendicite: attivazione microcircolatoria nel centro neuronale del GH-RH.;

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