I miei rapporti con i giornali di PLoS, Iniziati decenni or sono, improvvisamente si sono interrotti con la cancellazione immotivata dei miei numeroi commenti.
Per comprendere la mia indignazione di fronte a questo sospetto, desolante evento, che credevo possibile soltanto in Italia (documentazione a disposizione delle competenti Autorità), invito alla Lettura della seguente mail, non recapitata come altre di qusti giorni
https://journals.plos.org/plosmedicine/article/comment?id=10.1371/annotation/a4ee22bc-84b1-4b5b-9e52-51f3a0ee2624
Posted by Stagnaro on 23 Nov 2018 at 14:54 GMT
Compliment. You have cancelled all my previous comment, posted from years and months. Who is afraid about Medicine clinical advancments?
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002686
https://journals.plos.org/plosmedicine/article/comments/new?id=10.1371/journal.pmed.1002686
My 63-year-long, well established clinical experience allows me to state that often the differential diagnosis between benign and malignant pulmonary node is very difficult, despite the XR, TAC, NMR of the thorax. Therefore, the updated physical semeiotic can provide a decisive contribution (1-3).
References.
1) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
2) Sergio Stagnaro (2018). Manovra di Moncada*: Diagnosi Differenziale tra Lesione Benigna e Maligna in 15 secondi. in pdf. http://www.sisbq.org/uploads/5/6/8/7/5687930/manovradimoncada.pdf
3) SERGIO STAGNARO. MANOVRA DI MONCADA. RUOLO FISIOPATOLOGICO CENTRALE DELL’ACIDOSI ISTANGICA. HTTPS://SERGIOSTAGNARO.WORDPRESS.COM/2018/11/05/MANOVRA-DI-MONCADA-RUOLO-FISIOPATOLOGICO-CENTRALE-DELLACIDOSI-ISTANGICA/ ; HTTP://WWW.SISBQ.ORG/UPLOADS/5/6/8/7/5687930/MONCADA_FISIOPATOLOGIA.PDF; HTTPS://DABPENSIERO.WORDPRESS.COM/2018/11/05/MANOVRA-DI-MONCADA-RUOLO-FISIOPATOLOGICO-CENTRALE-DELLACIDOSI-ISTANGICA/
4) Sergio Stagnaro (2018). Manovra di Cris. Manovra clinica e rapida del Reale Rischio Congenito aspecifico non oncologico; ottobre 18, 2018 di dabpensiero. https://dabpensiero.wordpress.com/2018/10/18/manovra-di-cris/ e http://www.sisbq.org/uploads/5/6/8/7/5687930/manovradicris.pdf
5) Stagnaro Sergio. Variant Baserga’s Sign in bedside Diagnosing Lung Cancer Inherited Real Risk, from initial Stage. Postgrad Med J, 2009. http://pmj.bmj.com/content/85/1008/515/reply
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Come si può leggere, i commenti informano sulle mie ricerche cliniche, iniziate nel 1955 nella Clinica Medica del San Martino di Genova, diretta dal mio Maestro Prof. Lorenzo Antognetti, e tuttora in corso, condotte in tutti i campi della Medicina e dando vita ad altri, come la Microangiologia Clinica, la Diagnostica Semeiotico-Biofisico-Quantistica Endocrinologica, la Diagnostica Psicocinetica.
Certamente non politicamente corretti, i commenti evidenziano il Marcio esistente nel Regno della Medicina asservita al potere economico.
Dopo molti anni, gli Editori di PLoS hanno deciso – o sono stati costretti a – di prendere le distanze, immemori di avermi richiesto lavori sul T2DM!
Il Silenzio di PLoS crea inquietanti sospetti e corrobora la mia ennesima definizio nenegativa di Medicina criminale.
https://journals.plos.org/plosmedicine/article/comments?id=10.1371/journal.pmed.1002693
Bedside assessment of myocardial ischemia, even silent.
Posted by Stagnaro on 21 Nov 2018 at 12:47 GMT
A large number of myocardial ischemia are silent, so that general practitioners need a clinical method reliable in recognizing myocardial ischemia in asymptomatic patients, using a common stethoscope. In addition, all cases of myocardial ischemia, including AMI, are present from birth as Inherited Real Risk of CAD, which slowly evolves towards the overt disease, often, but not always, ending in the AMI. As a consequence, I emphasise the necessity of knowledge of Quantum Biophysical Semeiotic ATS Constitution-Dependent, Inherited Real Risks of cardiovascular disorders(1-5). Finally, phusicians need a clinical tool, reliable in enrolling exclusively individuals involved by CAD, even silent, to undergo angiography as soon as possible.
References.
1) Sergio Stagnaro and Simone Caramel. The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.or… [MEDLINE]
2) Sergio Stagnaro and Simone Caramel (2012). Magnesium deficiency clinical syndrome and magnesium therapy in hypertensives. European Journal of Clinical Nutrition , (27 June 2012) | d:10.1038/ejcn.2012.76, http://www.nature.com/ejc…
3) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., http://www.nature.com/ejc… [Medline]
4) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. www.athero.org, 29 April, 2009, International Atherosclerosis Society, http://www.athero.org/com…
5) Sergio Stagnaro. Il Reale Rischio Congenito di Infarto Miocardico: Fisiopatologia, Diagnosi e Terapia. Il Ruolo centrale svolto dal Diabete Mellito Tipo 2 Stagnaro https://sergiostagnaro.wo… e http://www.sisbq.org/uplo…
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204878
Up-dating physician’s physical semeiotic improves in the best way also the stewardship of antibiotics in the community. Based on a 63-year-long clinical experience, I state that an effective and successful strategy, aimed at the optimal prescription of antibiotics, includes clear communication of a non-bacterial diagnosis, lack of benefit of antibiotics, potential harms of antibiotics, and providing nonantibiotic prescriptions for symptom management. Therefore, the Quantum Biophysical Semeiotic has to be spread among physicians. The knowledge of Reticulum-Endothelial System Hyperfunction Syndrome, complete, incomplete, intermediate, the Acute Anti-body-poiesis Syndrome Activation of the adrenal glands, Terziani’s Manovra, Mancada’s Maneuver, Di Perri’s Maneuver, Domenichini’s Sign, Daneri’s a.s.o. are the basis of the new physical semeiotic, as far as, infectious diseses are concerned.
References.
1) Stagnaro S., Sindrome percusso-ascoltatoria di Iperfunzione del Sistema Reticolo-Istiocitario. Min. Med. 74, 479,1983 [Medline]
2) Stagnaro-Neri M., Stagnaro S., Appendicite. Min. Med. 87, 183, 1996 [Medline]
3) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica del torace, della circolazione ematica e dell’anticorpopoiesi acuta e cronica. Acta Med. Medit. 13, 25, 1997
4) Stagnaro-Neri M., Stagnaro S., Herpes Zoster. Min. Med. 78, 1404, 1987 [Medline]
5) Stagnaro Sergio. Subjects at Inherited Real Risk of A/H1N1 broncho-pneumonitis. MedicalPage, 4 November, 2009 http://www.medpagetoday.com/tbindex.cfm?tbid=16786#ayk
https://www.medpagetoday.com/infectiousdisease/uritheflu/16786#ayk
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https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007735
The relation between heritable mitochondrial impairment and CVD,T2DM, and Cancer.
Posted by Stagnaro on 15 Nov 2018 at 08:06 GMT
Since about 40 years I have discovered a singular mitocondrial cytopathy, and termed it Congenital Acidosic Enzyme-Metabolic Histangiopathy, enlightening the relation with CVD, T2DM, and Cancer (1-3). In addition, from the clinical wiew point, really interesting are the relative Constitution-Dependent, Inherited Real Risks, discovered later, i.e., 20 years ago (4, 5)
As a consequence, I agree with the data of this fascinating papers, corroborating from clinical view-point the statement “we posit that individuals with specific mtDNA variations may differentially metabolise carbohydrates which has implications for a variety of diseases including cardiovascular disease, obesity, and perhaps Parkinson’s Disease”.
References.
1) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. X Congr. Naz. Soc. It. di Microangiologia e Microcircolazione. Atti, 61. 6-7 Novembre, 1981. Siena.
2) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica condizione necessaria non sufficiente della oncogenesi. XI Congr. Naz. Soc. It. di Microangiologia e Microcircolaz. Abstracts, pg 38, 28 Settembre-1 Ottobre, 1983. Bellagio.
3) Sergio Stagnaro and Simone Caramel. BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention. Front. Genet. | doi: 10.3389/fgene.2013.00039. http://www.frontiersin.or… [MEDLINE]
4) Sergio Stagnaro and Simone Caramel. Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Front Endocrinol (Lausanne). 2013; 4: 17. Published online 2013 Feb 26. doi: [10.3389/fendo.2013.00017]http://www.frontiersin.or… [MEDLINE]
5) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., http://www.nature.com/ejc… [MEDLINE]
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https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002691 CANCELLED
SECOND Comment:
Do you really defeat AMI?
Posted by Stagnaro on 16 Nov 2018 at 08:41 GMT
Unfortunately, my previous comment ha been cancelled. The AMI epidemic will grow.
References.
1) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., http://www.nature.com/ejc… [Medline]
2) Sergio Stagnaro and Simone Caramel. The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.or… [MEDLINE]
3) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. International Atherosclerosis Society. www.athero.org, 29 April, 2009 http://www.athero.org/com…
Bedside diagnosing myocardial ischemia, starting from its ATS Constitution-Dependent, Inherited Real Risk.
Posted by Stagnaro on 14 Nov 2018 at 10:54 GMT
I agree with the statement that one of the reasons for the visual–functional mismatch is that myocardial ischemia can be affected by the supplied myocardial size, which is not always evident by coronary angiography. But there is another more important overlooked reason, that is enlightening the poor efficacy of coronary angiography. This method is obviously used late in the presence of symptoms of insufficient blood supply to the myocardium. Fortunately since 20 years physicians can bedsidediagnose quantitatively the CAD Inherited Real Risk, eliminating it with inexpensive Reconstructing Mitocondrial Quantum Therapy.
References
1. Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology, 2007. http://www.fac.org.ar/qcv…
2. Stagnaro Sergio. Bedside Evaluation of CAD biophysical-semeiotic inherited real risk under NIR-LED treatment. EMLA Congress, Laser Helsinki August 23-24, 2008. “Photodiagnosis and photodynamic therapy”, Elsevier, Vol. 5 suppl 1 august 2008 issn 1572-1000.
3. Sergio Stagnaro and Simone Caramel. The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.or… [MEDLINE]
4. Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., http://www.nature.com/ejc… [MEDLINE]
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204878
Antimicrobial stewardship, and NHS efficiency, depend on the quality of the Physical Semeiotic.
Posted by Stagnaro on 13 Nov 2018 at 10:36 GMT
The improvement of today physical semeiotic parallels that of antimicrobial stewardship. First of all, we must think of the human body composed for a part of Energy-Matter and for a billion parts as Energy-Information (1-3). Today’s physicians aren’t able to bedside recognize with a common stethoscope the real nature of an acute inflammatory disease, making a quick and reliable differential diagnosis among viral and bacterial infection, brought about by Gram-Negative or Gram-Positive bacteria (4, 5). In addition, only the efficient bedside monitoring of antibiotic therapy allows physician to ascertain the sensitivity of an infectious agent to the administered antibiotic. In conclusion, We need new clinical paradigms to improve antimicrobial stewardschip, in the sense of Quantum Biophysical Semeiotic.
References.
1) Sergio Stagnaro. Psychokinetic Diagnostics, Quantum Biophysica Semeiotics Evolution. http://sciphu.com/. , 12 March 2010, http://sciphu.com/2010/03… and http://wwwshiphusemeiotic…
2) Sergio Stagnaro. Realtà Locale e Non-Locale nella Medicina del Nuovo Rinascimento. https://dabpensiero.wordp…
3) Sergio Stagnaro. Dall’Esperimento di Lory alla Diagnostica Psicocinetica. Ruolo fondamentale della Realtà Non Locale in Biologia. http://www.fcenews.it, gennaio 2010. http://www.fceonline.it/i…
4) Stagnaro S., Auscultatory Percussion Therapeutic Monitoring and Cerebral Dominance in Rheumatology. 2nd World Congress of Inflammation, Antirheumatics, analgesics, immunomodulators. Abstracts, A. Book 1, pg. 116, March 19-22, Montecarlo.
5) Stagnaro S., Polimialgia Reumatica Acuta Benigna Variante. Clin. Ter. 118, 193,1986 [Medline]
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https://journals.plos.org/plospathogens/article/comment?id=10.1371/annotation/e260ac4a-a6af-452d-976a-bff7affd54dc
Glycocalic Bedside Evaluation informs on CIA machinery direction and insertionof newly formed Fe-S clusters into Proteins.
Posted by Stagnaro on 26 Oct 2018 at 12:44 GMT
There is a general agreement that cytosolic and nuclear proteins containing iron-sulphur clusters (Fe-S) are essential for the survival of every extant eukaryotic cell. The biogenesis of Fe-S clusters and their insertion into proteins is accomplished through the cytosolic iron-sulphur protein assembly (CIA) machinery. However, CIA is forming Fe-S clusters starting from a mitochondrial substance provided bu mitochondra, till now scarsely Known, the so-called X- substance (correspondence with Prof. Rolland Lill).
Interestingly, an outstanding question is the way by which the CIA machinery directs and inserts newly formed Fe-S clusters into proteins. Not everyone knows that nowadays Quantum Biophysical Semeiotic allows physicians to evaluate using a common stethoscopy the glycocalix, which can provide information on the structure and function of mit-DNA and n-DNA (1-5). As a consequence, if glycocalix is normal, also CIA machinery directs and inserts regularly newly formed Fe-S clusters into proteins.
References.
1) Simone Caramel and Sergio Stagnaro The role of glycocalyx in QBS diagnosis of Di Bella’s Oncological Terrain – http://www.sisbq.org/uplo…
2) Simone Caramel and Sergio Stagnaro Quantum Biophysical Semeiotics of Oncological Inherited Real Risk of Myelopathy: The diagnostic role of glycocalyx. http://www.sisbq.org/uplo…
3) Sergio Stagnaro. Glycocalix Quantum-Biophysical-Semeiotic Evaluation plays a Central Role in Demonstration of Water Memory-Information. www.sisbq.org. 19 July, 2011.http://www.sisbq.org/uploads/5/6/8/7/5687930/wmi_glycocalyx.pdf
4) Sergio Stagnaro and Simone Caramel (2011). Skeletal Muscle Cell Glycocalix Evaluation during CFS Treatment corroborates Andras Pellionisz’s Recursive Fractal Genome Function Principle. http://www.sisbq.org/uplo…
5) Sergio Stagnaro and Simone Caramel (2011). The genetic Reversibility in Oncology, Journal of Quantum Biophysical Semeiotics, http://www.sisbq.org/uplo…
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https://journals.plos.org/plosmedicine/article/comments/new?id=10.1371/journal.pmed.1002679
Pre Primary Prevention of Brain disorders: a promising original strategy in the future Medicine.
Posted by Stagnaro on 25 Oct 2018 at 09:24 GMT
People with psychosocial disabilities are growing on over the world. Among the important unresolved questions relating to psychosocial disabilities, there is one, really paramount, escaped US scholars and politicians. Before starting pregnancy, physicians must exclude in the young women the presence of predisposition to brain disorders with the medical examination. Beside a flurry number of Brain disorder Inherited Real Risks, removed by Reconstructing Mitochondrial Quantum Therapy, the cerebellum is a reliable sensor of all future cerebropathies (1-5). In doing so, we cut at the root the problems, CRPD activity is based on.
References.
1) Sergio Stagnaro. Il Cervelletto è un Sensore della Predisposizione all’Aterosclerosi Cerebrale. La Manovra di De Lisi. www.sisbq.org, http://www.sisbq.org/uplo…
2) Sergio Stagnaro (2018). Sergio Stagnaro (2018) Ruolo del Cervelletto nella Diagnosi clinica di Malattia di Parkinson a partire dal suo Reale Rischio Congenito. in pdf
http://www.sisbq.org/uplo…
3) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease Primary Prevention. Letter to the Editor, The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/… [Medline]
4) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Auscultatory Percussion of the Stomach Plays a Central Role in Bedside Diagnosis and Primary Prevention of Neurodegenerative Diseases and their Inherited Real Risks. 5th Annual World Congress Neotalk, Nijang, China, http://www.bitlifescience…
5) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g… [MEDLINE]
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https://journals.plos.org/plosone/article/comment?id=10.1371/annotation/bbe3ff20-0d1b-4213-967a-80f3db887c03
Posted by Stagnaro on 24 Oct 2018 at 06:16 GMT
Bedside diagnosing Oncological Terrain-Dependent, Inherited Real Risk of Ovarian Cancer.
Notoriously, ovarian cancer kills approximately 15.000 women in the United States every year, and more than 140,000 women worldwide. Most deaths from ovarian cancer are caused by tumours of the serous histological type, which are rarely diagnosed before the cancer has spread (1).
In a long, well-established, clinical experience, Quantum Biophysical Semeiotics proved to be reliable and useful tool also in early bedside detecting ovarian cancer, since its first stage, i.e., Oncological Terrain-Dependent, Inherited Real Risk, unfortunately mainly overlooked by physicians around the world (1-3).
In healthy woman, lying down on supine position, psycho-physically relaxed, and with open eyes to reduce endogenous melatonin secretion, lasting intense (1,000 dyne/cm.2) digital pressure on X thoracic dermatomere , at the lower region of right or left iliac fossa, i.e., ovarian trigger-points, brings about aspecific gastric reflex (= stomach fundus and body dilate, while antral-pyloric region contracts), after a latency time of exactly 8 sec.
The reflex lasts physiologically more than 3 sec. and less than 4 sec., due to local microcirculatory reason, showing the efficacy of Microcirculatory Functional Reserve, that is a really a paramount parameter value, since it parallels fractal dimension of related microvessell fluctuations, analized as ureteral reflex oscillation, more difficult to assess.
On the contrary, in any Inherited Real Risk of ovarian cancer, latency time is still the same, i.e. 8 sec. (NN = 8 sec.), but reflex duration interestingly lasts 4 sec. or more (NN > 3 < 4 sec.), in relation to severity of underlying disorder. Interestingly, after the reflex the stomach contracts pathologically, showing an intense local tissue acidosis: tonic Gastric Contraction (tGC), typical fo cancer, starting from the very initial stage at birth..
These parameter values (Explicate Order, according to D. Bohm) are based od ovarian microcirculatory abnormalities (Implicate Order), I have termed microcirculatory remodelling, characterised by newborn-pathological, type I, subtype a), oncological, Endoarteriolar Blocking Devices (3). More precisely speaking, reflex latency time becomes shorter than the normal 8 sec. in inverse relation to the tumour stage, initiatting when the heritable risk becomed activated, that is the true beginning of the oncogenesis. Moreover, in day-to-day practice, biophysical semeiotic ovarian preconditioning is very useful and reliable: exactly 5 sec. after the basal, initial manoeuvre, when ovarian Microcirculatory Functional Reserve is activated by digital pressure, doctor performs the above described test a second time.
In health, where Tonic Gastric Contraction is always absent, theLatency Time raises in a clear-cut manner, doubling its basal value: second latency time increases to 16 sec.
On the contrary, in ovarian cancer, even in its Inherited Real Risk, Latency Time either persists unchanged or increases not significantly in relation to the severity of ovarian cancer stage.
Importantly, latency time lowers significantly in case of overt ovarian cancer, since initial stages of its evolution.
Such a sign, easy to perform and reliable at the bed-side, is really useful in both ovarian cancer clinical diagnosis, among a large variety of other remarkable biophysical-semeiotic signs. In addition, as I described previously (2-5), malignancies occur on the base of a genetically transmitted mitochondrial cytopathology, I named Congenital Acidosic Enzyme-Metabolic Histangiopathy, conditio sine qua non of Oncological Terrain (1-5). These inherited abnormalities of psycho-neuro-endocrine-immunological system is mainly transmitted by mother’s mitochondria. Therefore, it is non-sense, or at least uselessly expensive, for instance, to ask if patient’s mother is, or was, involved by ovarian cancer, as well as assess oncological biomarkers and newly discovered mutated genes level in women without Oncological Terrain and/or whatever Cancer Inherited Real Risk.
All Inherited Real Risks are removed by Reconstructing Mitochondrial Quantum Therapy (5).
References
1) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. www.travelfactory.it
2) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, Luglio 2009.
3) Sergio Stagnaro. Bedside Diagnosing Ovarian Oncological Inherited Real Risk and Cancer. 27 December 2010. www.wordpress.com; http://stagnaro.wordpress… ; http://www.fcenews.it; http://www.fceonline.it/w… http://www.sci-vox.com; http://www.sci-vox.com/st… www.sciphu.com; http://wwwshiphusemeiotic…
4) Sergio Stagnaro. Moscatelli’s Sign: bedside recognizing in one second genital tract disorders, with a stethoscope. La Voce di SS. https://sergiostagnaro.wo…
5) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g… [MEDLINE]
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https://journals.plos.org…
As all other heritable predispositions to CVD, Osteoporosis, Brain degenerative Disorders, http://www.plosone.org/ar… it exists also Diabetic and Dislipidemic Constitution-Dependent Inherited Real Risk of Type 2 Diabetes Mellitus (1-3). Bedside diagnosed from birth with a common stethoscope, such a Inherited Real Risk is removed by Reconstructing Mitochondrial Quantum Therapy (4,5).
References.
1) Sergio Stagnaro and Simone Caramel. Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology (Lausanne). 2013; 4: 17. http://www.frontiersin.or… [Medline].
2) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [Medline]
3) Sergio Stagnaro. Siniscalchi’s Sign. Bedside Recognizing, in one Second, Diabetic Constitution, its Inherited Real Risk, and Type 2 Diabetes Mellitus. 24 December, 2010, http://www.sci-vox.com, http://www.sci-vox.com/st… www.sciphu.com; http://wwwshiphusemeiotic…
4) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g… [MEDLINE]
5) Simone Caramel, Marco Marchionni and Sergio Stagnaro. The Glycocalyx Bedside Evaluation Plays A Central Role in Diagnosing Type 2 Diabetes Mellitus and in its Primary Prevention. Treatment Strategies – Diagnosing Diabetes, Cambridge Research Centre, Volume 6 Issue 1, Pg 41-43. http://viewer.zmags.com/p…
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https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002670
As all other heritable predispositions to CVD, Osteoporosis, Brain degenerative Disorders, http://www.plosone.org/article/comment/info%3Adoi%2F10.1371%2Fjournal.pone.0006354;jsessionid=9AC82C42FA9F57C913844806BF96DDC1, it exists also Diabetic and Dislipidemic Constitution-Dependent Inherited Real Risk of Type 2 Diabetes Mellitus (1-3). Bedside diagnosed from birth with a common stethoscope, such a Inherited Real Risk is removed by Reconstructing Mitochondrial Quantum Therapy (4,5).
References.
1) Sergio Stagnaro and Simone Caramel. Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology (Lausanne). 2013; 4: 17. http://www.frontiersin.org/Review/ReviewForum.aspx [Medline].
2) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [Medline]
3) Sergio Stagnaro. Siniscalchi’s Sign. Bedside Recognizing, in one Second, Diabetic Constitution, its Inherited Real Risk, and Type 2 Diabetes Mellitus. 24 December, 2010, http://www.sci-vox.com, http://www.sci-vox.com/stories/story/2010-12-25siniscalchi%27signi.bedside++diagnosing+type+2+dm.html; http://www.sciphu.com; http://wwwshiphusemeioticscom-stagnaro.blogspot.com/
4) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov/pubmed/25743850 [MEDLINE]
5) Simone Caramel, Marco Marchionni and Sergio Stagnaro. The Glycocalyx Bedside Evaluation Plays A Central Role in Diagnosing Type 2 Diabetes Mellitus and in its Primary Prevention. Treatment Strategies – Diagnosing Diabetes, Cambridge Research Centre, Volume 6 Issue 1, Pg 41-43. http://viewer.zmags.com/publication/0aafcae9#/0aafcae9/1
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https://journals.plos.org/plosmedicine/article/comment?id=10.1371/annotation/c4c142f5-20e5-4834-a5d8-4b106ba1796a
Without Diabetic and Dislipidemic Constitution-Dependent, Inherited Real Risk, T2DM cannot occur.
Posted by Stagnaro on 13 Oct 2018 at 07:09 GMT
nce again a research fundamentally biased. How can the Authors state that diary fats “may” prevent T2DM, if they ignore the Inherited Real Risks of Diabetes Mellitus in the subjects enrolled in the research? In addition, such a predisposition to DM, bedside diagnosed , starting from the birth, is removed definitively by inexpensive Reconstrutting Mitochondrial Quantum Therapy (1-4).
References
1)Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [Medline]
2) Sergio Stagnaro and Simone Caramel. Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology (Lausanne). 2013; 4: 17. http://www.frontiersin.or… [Medline].
3) Simone Caramel, Marco Marchionni and Sergio Stagnaro. The Glycocalyx Bedside Evaluation Plays A Central Role in Diagnosing Type 2 Diabetes Mellitus and in its Primary Prevention. Treatment Strategies – Diagnosing Diabetes, Cambridge Research Centre, Volume 6 Issue 1, Pg 41-43. http://viewer.zmags.com/p…
4) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g… [MEDLINE]
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201264
ATS Constitution-Dependent, Inherited Real Risk of CAD.
Posted by Stagnaro on 03 Oct 2018 at 06:20 GMT
I find this study facinating, but tragically incomplete. As a matter of facts, among the large number of existing studies in the literature, providing just a preliminary understanding of which factors mostly affect injury risk, none highlights the most serious, i.e., ATS Constitution-Dependent, Inherited Real Risk of CAD (1-4), and recently referred in a intersting comment at URL http://journals.plos.org/…. Bedside diagnosed from birth, using a common stethoscope, CAD Inherited Real Risk is removed by inexpensive Reconstructing Mitochondrial Quantum Therapy, better if in a personalized form (5).
References.
1) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. Internaional Atherosclerosis Society. www.athero.org, 29 April, 2009 http://www.athero.org/com…
2) Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology. http://www.fac.org.ar/qcv…
3) Sergio Stagnaro and Simone Caramel (2013). The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., [MEDLINE]
4) Sergio Stagnaro and Simone Caramel. The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.or… [MEDLINE]
5) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g… [MEDLINE]
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https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002941 NO!
I find Philip E. Bourne argumentations extremely important. However, let’s consider that, despite about 33.000 peer-reviews, publishing montly millions of articles of oustanding Oncologists, CVD, T2DM, Osteoporosis, and Cancer are till now growing epidemics.Not only Medicine progress but also the current war against these disorders are to be ameliorated. For instance, the fight against cancer is based falsely on screening, i.e. secondary prevention, and a scarsely efficient but expensive treatment, as the growing epidemic of cancer demostrates. The Fake News worry Editors and Oncologists, who continue however to ignore the effective, inexpensive, realizable rationally on very large scale, even in undeveloped and developing Countries, Pre-primary and Primary Prevention of cancer, according to Quantum Biophysical Semeiotic (1-3). In additon, informing doctors with little expense is a goal to be achieved. I would like to ask to all professors, mentioned in the Editorial, if they know their possible Oncological Terrain-Dependent, Inherited Real Risk as well as Reconstructing Mitochondrial Quantum Therapy (5). Overlooking the above-mentioned progress of Medicine in general and of Oncology in particular, accounts for the reason we must offer these advancements via Internet, free, as International Society of Quantum Biophysical Semeiotic does since ever. Unfortunately, of the two sides of the Medicine coin – pre-primary and primary prevention and cancer therapy – oncologists know strangely only the second.
1) Sergio Stagnaro and Simone Caramel.BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention. Front. Genet. | doi: 10.3389/fgene.2013.00039. http://www.frontiersin.org/Cancer_Genetics/10.3389/fgene.2013.00039/full [MEDLINE]
2) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004.http://www.travelfactory.it/semeiotica_biofisica.htm
3) Stagnaro S., Stagnaro-Neri M., Oncological Terrain, conditio sine qua non of Oncogenesis: http://www.gutjnl.com/cgi/eletters?lookup=by_date&days=60
4) Sergio Stagnaro. Early bedside Diagnosis of Pancreas Cancer, starting from its Oncological Terrain-Dependent, Inherited Real Risk http://www.sisbq.org/uploads/5/6/8/7/5687930/norimbergasign_pancreascancer.pdf ; Slide Presentation at URL http://www.sisbq.org/uploads/5/6/8/7/5687930/cancropancreas_2015.pdf
5) Caramel S., Marchionni M., Stagnaro S.Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov/pubmed/25743850 [MEDLINE]___________________________________________________
NO!
https://journals.plos.org/plosmedicine/article/comments/new?id=10.1371/journal.pmed.1002658
Physicians skilled in Quantum Biophysical Semeiotic (QBS) are able to bedside evaluate with a common stethoscope in quantitative way a flurry of signs in Tubercolosis as well as in all other infective disorders. The most important signs are the complete Reticulo-Endotelial System Hyperfuction Syndrome, RESHS, (only in the flu viroses RESHS is incomplete: the spleen does’nt augment its antibody production) , more precise and specific than ESR , Acute Antibody Synthesis, PCR, Microcirculatory Activation of Adrenal glands, a.s.o. (1-5). As a consequence, accurate prediction of susceptibility to first-line Tuberculosis drugs is possible at the bedside, through the QBS evaluation of the positive modifications of numerous signs mentioned above.
References.
1) Stagnaro S., Sindrome percusso-ascoltatoria di Iperfunzione del Sistema Reticolo-Istiocitario. Min. Med. 74, 479, 1983 [Medline]
2) Stagnaro S., Polimialgia Reumatica Acuta Benigna Variante. Clin. Ter. 118, 193, 1986 [Medline]
3) Stagnaro S., Auscultatory Percussion Therapeutic Monitoring and Cerebral Dominance in Rheumatology. 2nd World Congress of Inflammation, Antirheumatics, analgesics, immunomodulators. Abstracts, A. Book 1 ___________________________________________________________________________________
https://journals.plos.org/plosmedicine/article/comments/new?id=10.1371/journal.pmed.1002660
Alzheimer Disease Inherited Real Risk plays a central Role in its Pre-Primary and Primary Prevention.
Posted by Stagnaro on 26 Sep 2018 at 14:39 GMT
Calcium-antagonists can slow moderate and mild forms of Alzheimer’s disease (AD), improving brain microcirculation. As a matter of facts, Quantum Biophysical Semeiotics is able to make since birth the diagnosis of AD Inherited Real Risk (1-5) and of numerous brain disorders, http://www.plosone.org/ar…. Easily, through the Auscultatory Percussion of th stomach, digital pressure of the typical areas of Alzheimer disease, i.e., pre-frontal areas, limbic region, this original semeiotic can reveal if any subject, from the moment of birth, is at risk of such disorder.
There are two main QBS tests usefull in bedside diagnosing AD since birth: the test of microcirculatory activation of the above-mentioned areas of brain, and the insulin secretion acute peak test. Furthermore, there is a Quantum Entanglement Sign, which can reveal the Inherited Real Risk of brain disorder, specially related to Alzheimer disease.
Alzheimer Disease is not reversible by medical treatments, and the current research is concentrated just on genetic and histological clinical tests, while QBS is able for the first time to provide for such disorder a biological evaluation, because biological system functional modification parallels gene mutation. Furthermore QBS is able to make a diagnosis of AD not only at the first very initial stages, usually very difficult to do, but even many years before that such disease could appear, allowing so an efficacious primary prevention, according to the Manuel’s Story.
References.
1) Stagnaro Sergio. Alzheimer’s Disease Byophysical Semeiotics supports the pathophysiology of Koudinov’s theory.11 January 2002. Clin. Med. & Health Research http://clinmed.netprints….
2) Simone Caramel and Sergio Stagnaro. Clinical QBS Diagnosis and Primary Prevention of Brain Disorder ‘Inherited Real Risk’ and Alzheimer Disease. Journal of Quantum Biophysical Semeiotics. 5 August, 2011. http://www.sisbq.org/uplo…
3) Marco Marchionni, Simone Caramel, Sergio Stagnaro. Inherited Real Risk of Alzheimer’s Disease: bedside diagnosis and primary prevention.Frontiers in Neuroscience, in http://www.frontiersin.or…
4) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease Primary Prevention. Letter to the Editor, The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/… [Medline]
5) Sergio Stagnaro. Il Segno di Scopinaro: un pizzicotto cutaneo permette in 3 secondi di fare la Diagnosi Differenziale tra Malattia di Alzheimer e Demenza Senile.
http://www.sisbq.org/uplo…
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http://journals.plos.org/plosbiology/article/comments?id=10.1371/journal.pbio.2005143 NO
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http://blogs.plos.org/speakingofmedicine/2018/06/07/the-power-of-the-pediatricians-voice-reflections-on-pas-2018/comment-page-1/#comment-251157
Sergio Stagnaro
June 8, 2018 at 9:17 am NO
Your comment is awaiting moderation.
0000-0003-4532-086Y
Pediatric Academic Societies (PAS) could revolutionize pediatrics by starting off the pediatrics of the New Medical Renaissance, spreading Constitution-Dependent, Inherited Real Risks of the most common and deadly diseases, such as CVD, T2DM, Cancer, today’s growing epidemics (1-4). Interestingly, these predispositions are diagnosed beginning at birth, using the common stethoscope, and eliminated with inexpensive reconstructing mitochondrial quantum therapy (5).
References.
1) Sergio Stagnaro and Simone Caramel. BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention. Front. Genet. | doi: 10.3389/fgene.2013.00039. http://www.frontiersin.org/Cancer_Genetics/10.3389/fgene.2013.00039/full [MEDLINE]
2) Sergio Stagnaro and Simone Caramel. The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.org/Epigenomics_and_Epigenetics/10.3389/fgene.2013.00055/full [MEDLINE]
3) Sergio Stagnaro and Simone Caramel. Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology (Lausanne). 2013; 4: 17. http://www.frontiersin.org/Review/ReviewForum.aspx [Medline].
4) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease Primary Prevention. Letter to the Editor, The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/article/10.1007/s12603-013-0435-7 [MEDLINE]
5) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov/pubmed/25743850 [MEDLINE]
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http://journals.plos.org/plosmedicine/article/comment?id=10.1371/annotation/ccd98f16-0aeb-4d0f-b15b-9241725c3d2e
The spreading of the progress of Clinical Medicine must improve.
Cancelled! My second comment:
As I had expected
Posted by Stagnaro on 22 May 2018 at 15:38 GMT
See my previous cancelled comment at URL https://www.facebook.com/…
Unfortunately, you cannot accept not politically correct comments. Never minds!
No competing interests declared.
Unfortunately, you cannot accept not politically correct comments. Never minds!
Posted by Stagnaro on 22 May 2018 at 13:08 GMT
We all must agree with the following statement: “While scientists can work to improve science, governments and regulators can also do better. Most governments around the world have largely neglected the need to support reproducible research practices”. For instance, Italian governments and competent health authorithies ignored, and till now ignore, the progress of Clinical Medicine, carried out in their Country: Quantum Biophysical Semeiotic-Dependent, Inherited Real Risks of CVD, T2DM, Osteoporosis, Alzheimer Disease, Cancer, Manuel’s Story, Logo of Epigenetics, Reconstructing Mitochondrial Quantum Therapy, and thus Pre-Primary and Primary Prevention. As a consequence, T2DM, cardiovasculopathy, osteoporosis and cancer, leading cause of mortality, are today’s growing epidemics.
References
1) Sergio Stagnaro and Simone Caramel. BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention. Front. Genet. | doi: 10.3389/fgene.2013.00039. http://www.frontiersin.or… [MEDLINE]
2) Sergio Stagnaro and Simone Caramel (2013). The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., 67, 683 (June 2013) | doi:10.1038/ejcn.2013.37, http://www.nature.com/ejc…. [MEDLINE].
3) Sergio Stagnaro and Simone Caramel (2012). Quantum Therapy: A New Way in Osteoporosis Primary Prevention and Treatment. Journal of Pharmacy and Nutrition Sciences, (27 June 2012) | doi:10.1038/ejcn.2012.76, http://www.nature.com/doi…. PMID:22739250 [MEDLINE].
4) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease Primary Prevention. Letter to the Editor, The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/… [MEDLINE].
5) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g… [MEDLINE].
No competing interests declared.
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cancelled
Glioblastoma, unique cancer that can arise in individuals negative for Oncological Terrain.
Posted by Stagnaro on 21 May 2018 at 12:36 GMT
This fascinating article is really usefull in understanding the strange behavior of the origin and progression of glioblastoma. In fact, this is the only malignant tumor, to my best knowledge, that can also arise in subjects without Oncological Terrain (1-5).
References.
1) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory….
2) Stagnaro Sergio. Overlooking Oncological Terrain-Dependent Inherited Real Risk such as Research is fundamentally Biased. PLoS ONE. 12 December 2009. http://www.plosone.org/ar…
3) Simone Caramel and Sergio Stagnaro The role of glycocalyx in QBS diagnosis of Di Bella’s Oncological Terrain – http://www.sisbq.org/uplo…
4) Sergio Stagnaro. Early bedside Diagnosis of Pancreas Cancer, starting from its Oncological Terrain-Dependent, Inherited Real Risk http://www.sisbq.org/uplo… ; Slide Presentation at URL http://www.sisbq.org/uplo…
5) Sergio Stagnaro. Glioblastoma: Diagnosi Semeiotico-Biofisico-Quantistica a iniziare dal suo Reale Rischio Congenito. Giugno 14, 2017, https://dabpensiero.wordp…
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Cerebellum is a Sensor of Brain ATS with and without senile Dementia.
Posted by Stagnaro on 21 May 2018 at 05:34 GMT
Firstly, from indivisual’s birth, Cerebellum is the sensor Brain future ATS, with and without Dementia (1). Secondly, tehre is also the Inherited Real Risk of AD, bedside diagnosed from birth, and removed by inexpensive Reconstructing Mitochondrial Quantum Therapy (2, 3). As a consequence, to ameliorate people life by means of Primary Prevention, World Health Organization would spread among physicians these advances of Medicine.
References.
1) Sergio Stagnaro. Il Cervelletto è un Sensore della Predisposizione all’Aterosclerosi Cerebrale. La Manovra di De Lisi. www.sisbq.org, http://www.sisbq.org/uplo…
2) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease Primary Prevention. Letter to the Editor, The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/… [Medline]
3) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g… [MEDLINE]
No competing interests declared.
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Diabetic Constitution-Dependent, Inherited Real Risk.
Posted by Stagnaro on 19 May 2018 at 07:05 GMT
We must prevent T2DM exclusively in individuals involved from birth by Diabetic Constitution-Dependent, Inherited Real Risk of T2DM (1-3).
References.
1) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [Medline]
2)Sergio Stagnaro and Simone Caramel. Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology (Lausanne). 2013; 4: 17. http://www.frontiersin.or… [Medline].
3)Simone Caramel, Marco Marchionni and Sergio Stagnaro. The Glycocalyx Bedside Evaluation Plays A Central Role in Diagnosing Type 2 Diabetes Mellitus and in its Primary Prevention. Treatment Strategies – Diagnosing Diabetes, Cambridge Research Centre, Volume 6 Issue 1, Pg 41-43. http://viewer.zmags.com/p…
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http://journals.plos.org/plosmedicine/article/comment?id=10.1371/annotation/e0b1f178-74f6-49b8-bcc8-9dfdcab509d0
Overlooked the most important risk: Constitution-Dependent, Inherited Real Risk.
Unfortunately, this article overlooks the Constitution-Dependent, Inherited Real Risks, Pre-Primary and Primary Prevention are based on. We can now prevent chronic disorders, as CVD, T2DM, Osteoporosis and Cancer, bedside diagnosing with a common stethoscope from birth all Constitution-Dependent, Inherited Real Risks, removed by inexpensive Mitochondrial Restructuring Quantum Therapy. As a consequence, the budgets in red of NHS, all around the world, could be optimized, as well as improving physician performances, if physicians will learn to bedside diagnose these Inherited Real Risks, using stethoscope.
References.
1)The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease Primary Prevention. The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/… [ Medline];
2) The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., European Journal of Clinical Nutrition 67, 683 (June 2013) | doi:10.1038/ejcn.2013.37, http://www.nature.com/ejc… [Medline];
3) Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology (Lausanne). 2013; 4: 17. http://www.frontiersin.or
4) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [Medline]
5) Sergio Stagnaro and Simone Caramel. BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention. Front. Genet. | doi: 10.3389/fgene.2013.00039. http://www.frontiersin.or… [MEDLINE]
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http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002506
No politically comment are rejected?
Posted by Stagnaro on 22 Feb 2018 at 09:37 GMT
Dear PLoS friends,
my previoius comment has been cancelled because it was no politically correct? Here it’s: “Musella’s Sign in bedside detecting Lung Cancer starting from its Oncological Terrain, Dependent Inherited Real Risk.
Posted by Stagnaro on 19 Feb 2018 at 15:42 GMT
Musella’s Sign, http://www.sisbq.org/uplo… allows physician to bedside detecting with a common stethoscope the Lung Cancer starting from birth, namely from its Oncological Terrain, Dependent, Inherited Real Risk. Intense digital pressure (1,000 dyne/cm.2), applied on any skin projection are of the lung, due to no-local reality in biological systems, brings about simultaneously the aspecifc gastric reflex (in the stomach, fundus and body dilate, while antral-pyloric region contracts), followed immediately by typical tonic gastric contraction”.
If the facts are these, I will not send more comments. Keep calm.
No competing interests declared.
__________ _________________ ______________
Bedside Primary Prevention of Lung Cancer must replace screening.
Posted by Stagnaro on 21 Feb 2018 at 13:56 GMT
I recently wrote in PLosMedicine web-site, http://journals.plos.org/… that bedside Primary Prevention of Lung Cancer, using a common stethoscope, is far better than the screening. As a matter of facts, a 63-year-long clinical experience allows me to state that Baserga’s variant Sign (1-5) is the best method to stop the growing epidemic of lung cancer, allowing physicians to recognize from birth lung cancer Inherited Real Risk, removed by inexpensive Reconstructing Mitochoondrial Quantum Therapy (5). This original sign is based on the stimulation of sternal bone marrow, brought about by erythropoietin-like substance, secreted by malignat cell, even in its first stage, i.e., Inherited Real Risk.
Bedside Primary Prevention of Lung Cancer must replace screening.
CANCELLED due to Reference
Posted by Stagnaro on 21 Feb 2018 at 13:56 GMT
I recently wrote in PLosMedicine web-site, http://journals.plos.org/… that bedside Primary Prevention of Lung Cancer, using a common stethoscope, is far better than the screening. As a matter of facts, a 63-year-long clinical experience allows me to state that Baserga’s variant Sign (1-5) is the best method to stop the growing epidemic of lung cancer, allowing physicians to recognize from birth lung cancer Inherited Real Risk, removed by inexpensive Reconstructing Mitochoondrial Quantum Therapy (5). This original sign is based on the stimulation of sternal bone marrow, brought about by erythropoietin-like substance, secreted by malignat cell, even in its first stage, i.e., Inherited Real Risk.
References
1) Stagnaro S. Segno di Baserga: diagnosi clinica semeiotico-biofisica della carenza di ferro mediante valutazione dell’attività midollare dell’eritropoietina endogena. URL: http://www.semeioticabiof…
2) Stagnaro Sergio. Bedside Recognizing Lung Cancer Inherited Real Risk rather than IL-12 treatment. www.plosone.org, 2 July, 2009. http://www.plosone.org/an…
3) Stagnaro Sergio. Variant Baserga’s Sign in bedside Diagnosing Lung Cancer Inherited Real Risk, from initial Stage. Postgrad Med J, 2009. http://pmj.bmj.com/conten…
4) Sergio Stagnaro. Bedside Diagnosis of Lung Cancer Inherited Real Risk. 28 January, 2011. http://www.sci-vox.com, http://www.sci-vox.com/st…
5) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g…[MEDLINE]
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Musella’s Sign in bedside detecting Lung Cancer starting from its Oncological Terrain, Dependent Inherited Real Risk.
Posted by Stagnaro on 19 Feb 2018 at 15:42 GMT
Musella’s Sign, http://www.sisbq.org/uplo… allows physician to bedside detecting with a common stethoscope the Lung Cancer starting from birth, namely from its Oncological Terrain, Dependent, Inherited Real Risk. Intense digital pressure (1,000 dyne/cm.2), applied on any skin projection are of the lung, due to no-local reality in biological systems, brings about simultaneously the aspecifc gastric reflex (in the stomach, fundus and body dilate, while antral-pyloric region contracts), followed immediately by typical tonic gastric contraction.
_____________________________________________________________
http://researchnews.plos.org/2017/10/06/research-roundup-brain-cooling-experiment-may-help-ease-epilepsy-someday-ornamented-artifact-may-indicate-exchange-between-mesolithic-communities/#comment-22926
Sergio Stagnaro February 17, 2018 at 10:29 am
The comprehension of the pathogenesis of epilepsy finds a new impulse in studies on nonlinear dynamics of EEG signals and in the growing genetic molecular evidence of the mitochondrial origin of this disease. These data are consistent with the information registered bedside by Quantum Biophysical Semeiotics that clinically investigates microcirculation, both on a functional
viewpoint (by studying deterministic chaotic dynamics) and on a structural viewpoint (1, 2). Microcirculatory dysfunctions reflect those of a genetically altered mit-DNA and of a functional mitochondrial cytopathy, known as Congenital Acidosic Enzyme-Metabolic Histangiopathy, originating from this mutation and which is particularly intense both in patients with epilepsy
and in those with an Inherited Real Risk of epilepsy (2). Preclinical diagnosis of an Inherited Real Risk of epilepsy allows physicians to finely select subjects with a predisposition to this disease since birth in order to perform an efficient pre-primary and primary prevention.
References.
1) Marco Marchionni, Simone Caramel, Sergio Stagnaro. QBS Inherited Real Risk of epilepsy: physiopathology, diagnosis and primary prevention – 2014. Journal of QBS, http://www.sisbq.org/uploads/5/6/8/7/5687930/iirrofepilepsy.pdf
2) Marco Marchionni, Simone Caramel, Sergio Stagnaro. Integrated Quantum Therapy in an Epileptic Child after 13 Years of Inherited Real Risk of Epilepsy in Evolution: A Case Study. NeuroQuantology, Vol 14, No 2 (2016)
3) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov/pubmed/25743850 [MEDLINE]
Your comment is awaiting moderation.
Reply
___________________________________________________________________________
Sergio Stagnaro February 17, 2018 at 10:29 am
Your comment is awaiting moderation.
The comprehension of the pathogenesis of epilepsy finds a new impulse in studies on nonlinear dynamics of EEG signals and in the growing genetic molecular evidence of the mitochondrial origin of this disease. These data are consistent with the information registered bedside by Quantum Biophysical Semeiotics that clinically investigates microcirculation, both on a functional
viewpoint (by studying deterministic chaotic dynamics) and on a structural viewpoint (1, 2). Microcirculatory dysfunctions reflect those of a genetically altered mit-DNA and of a functional mitochondrial cytopathy, known as Congenital Acidosic Enzyme-Metabolic Histangiopathy, originating from this mutation and which is particularly intense both in patients with epilepsy
and in those with an Inherited Real Risk of epilepsy (2). Preclinical diagnosis of an Inherited Real Risk of epilepsy allows physicians to finely select subjects with a predisposition to this disease since birth in order to perform an efficient pre-primary and primary prevention.
References.
1) Marco Marchionni, Simone Caramel, Sergio Stagnaro. QBS Inherited Real Risk of epilepsy: physiopathology, diagnosis and primary prevention – 2014. Journal of QBS, http://www.sisbq.org/uploads/5/6/8/7/5687930/iirrofepilepsy.pdf
2) Marco Marchionni, Simone Caramel, Sergio Stagnaro. Integrated Quantum Therapy in an Epileptic Child after 13 Years of Inherited Real Risk of Epilepsy in Evolution: A Case Study. NeuroQuantology, Vol 14, No 2 (2016)
3) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov/pubmed/25743850 [MEDLINE]
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http://journals.plos.org/plosmedicine/article/comment?id=10.1371/annotation/98ec6d53-160e-44dc-9c22-e311487e6e69
cancelled!
Bedside Primary Prevention of Lung Cancer is far better than the screening.
Posted by Stagnaro on 16 Feb 2018 at 17:15 GMT
A 63-year-long clinical experience allows me to state that Baserga’s variant Sign (1-5) is the best method to stop the growing epidemic of lung cancer. This original sign is based on the stimulation of bone marrow, broght about by erythropoietin-like substance, secreted by malignat cell, even in it Inherited Real Risk.
References
1) Stagnaro S. Segno di Baserga: diagnosi clinica semeiotico-biofisica della carenza di ferro mediante valutazione dell’attività midollare dell’eritropoietina endogena. URL: http://www.semeioticabiof…
2) Stagnaro Sergio. Bedside Recognizing Lung Cancer Inherited Real Risk rather than IL-12 treatment. www.plosone.org, 2 July, 2009. http://www.plosone.org/an…
3) Stagnaro Sergio. Variant Baserga’s Sign in bedside Diagnosing Lung Cancer Inherited Real Risk, from initial Stage. Postgrad Med J, 2009. http://pmj.bmj.com/conten…
4) Sergio Stagnaro. Bedside Diagnosis of Lung Cancer Inherited Real Risk. 28 January, 2011. http://www.sci-vox.com, http://www.sci-vox.com/st…
5) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g…[MEDLINE]
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http://journals.plos.org/plosmedicine/article/comment?id=10.1371/annotation/338f5739-26d4-4c94-8aae-f69be934799e
cancelled!
Clinical Primary Prevention of Lung Cancer based on its Inherited Real Risk.
Posted by Stagnaro on 14 Feb 2018 at 16:58 GMT
The early bedside diagnosis of lung cancer, starting from its first stage of Inherited Real Risk, I’ve termed the Sign of Musella, https://sergiostagnaro.wo… -musella-the-silence-of-professors-and-different-from-my /, would save thousands of lives (1-3).
Moreover, such a diagnostic weapon would also facilitate the clinical in differential diagnosing between benign and malignant nodes of the lung, avoiding the present and distressing psychological terrorism.
References
tentare di falsificarlo?
1)Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory….
2) Stagnaro Sergio. Bedside Recognizing Lung Cancer Inherited Real Risk rather than IL-12 treatment. www.plosone.org, 2 July, 2009. <a href=”http://www.plosone.orghtt…
3) Sergio Stagnaro and Simone Caramel. The Role of Modified Mediterranean Diet and Quantum Therapy in Oncological Primary Prevention. Bentham PG.,Current Nutrition & Food Science ISSN (Print): 1573-4013; ISSN (Online): 2212-3881. VOLUME: 9, ISSUE: 1; DOI: 10.2174/1573401311309010011;
http://www.eurekaselect.c….
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http://journals.plos.org/plosone/article/comments?id=10.1371/journal.pone.0192646
The best AD diagnosis is based on its Inherited Real Risk.
Posted by Stagnaro on 13 Feb 2018 at 07:27 GMT
As in all diseases, especially if they are incurable, primary prevention is the best therapy. I can not believe, but it’s true unfortunately, that the majorety of Editors and Aathors worldly ignore till now the Inherited Real Risk of Alzheimer’s Disease (1-4) as well as that the cerebellum is a sensor of the future senile Dementia (5). On these two realities,i.e., two facts, is founded my overlooked clinical fight against the AD and the Brain ATS, with or without senile Dementia, Interestingly, as all other Inherited Real Risks, of CVD/CAD, T2DM, Osteoporosis, Cancer, a.s.o., AD Inherited Real Risk can be bedside diagnosed from birth with a common stethoscope and removed by inexpensive, personalizad Reconstructing Mitochondrial Quantum Therapy, (6).
1) Stagnaro Sergio. Alzheimer’s Disease Byophysical Semeiotics supports the pathophysiology of Koudinov’s theory.11 January 2002. Clin. Med. & Health Research http://clinmed.netprints….
2) Simone Caramel and Sergio Stagnaro. Clinical QBS Diagnosis and Primary Prevention of Brain Disorder ‘Inherited Real Risk’ and Alzheimer Disease. Journal of Quantum Biophysical Semeiotics. 5 August, 2011. http://www.sisbq.org/uplo…
3) Marco Marchionni, Simone Caramel, Sergio Stagnaro. Inherited Real Risk of Alzheimer’s Disease: bedside diagnosis and primary prevention.Frontiers in Neuroscience, in http://www.frontiersin.or…
4) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease Primary Prevention. Letter to the Editor, The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/… [Medline]
5) Sergio Stagnaro. Il Cervelletto è un Sensore della Predisposizione all’Aterosclerosi Cerebrale. La Manovra di De Lisi. www.sisbq.org, http://www.sisbq.org/uplo…
6) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g… [MEDLINE]
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The cerebellum is from birth the brain’s ATS sensor with and without dementia.
Posted by Stagnaro on 11 Feb 2018 at 16:48 GMT
In a previous paper I have described and illustrated patho-physiological mechanisms that accounts for the reason the cerebellum is from birth the brain’s ATS sensor with and without dementia (1). The bedside microcirculatory evaluation in the middle-anterior part of the cerebellum, allows the physician to diagnose the above-mentioned Inherited Real Risk, dependent on ATS Constitution (2). Unfortunately, such a paper is in Italian. I hope the discovery will interest my colleagues and someone will translate it into English. With the inexpensive therapy Reconstructing Mitochondrial Quantum Therapy (3), the physician eliminates the heritable predisposition to atherosclerosis of the brain, that notoriously brings about serious damage to families. Interestingly, all mothers, even apparently healthy, of patients involved by brain ATS, are positive for this heritable risk
1) Sergio Stagnaro. Il Cervelletto è un Sensore della Predisposizione all’Aterosclerosi Cerebrale. La Manovra di De Lisi. www.sisbq.org, http://www.sisbq.org/uplo…
2) Sergio Stagnaro and Simone Caramel. The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.or… [MEDLINE]
3) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g… [MEDLINE]
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Inherited Real Risks play a central role in tomorrow’s Single Patient Based Medicine.
Posted by Stagnaro on 11 Feb 2018 at 12:26 GMT
Firstly, incurable diseases must be prevented. CVD, T2DM, Cancer, Rheumopathies, a.s.o. are today’s growing epidemics.
Secondly, Pre-Primary and Primary Prevention is possible on very large scale, enrolling exclusively individuals at heritable risks, at the condition physicians can bedside recognize Inherited Real Risks with a common stethoscope, starting from birth (1-5).
Thirdly, we need a efficacious, inexpensive therapy to eliminate all predisposition to above-mentioned deadly disorders, as Reconstructing Mitochondrial Quantum Therapy (5).
In conclusion, Inherited Real Risks play a central role in tomorrows Single Patient Based Medicine.
1) Stagnaro Sergio. Single Patient Based Medicine: its paramount role in Future Medicine. Public Library of Science. http://medicine.plosjourn…
2) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004. http://www.travelfactory….
3) Stagnaro S., Stagnaro-Neri M., Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory, Roma, 2005. http://www.travelfactory….
4) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory….
5) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, 2009.
5) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g… [MEDLINE]
No competing interests declared.
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Construction of an infectious horsepox virus vaccine versus spreading Constitution-depedent, Inherited Real Risks of CVD/CAD, T2DM, and Cancer.
Posted by Stagnaro on 23 Jan 2018 at 15:47 GMT
All around the world children are vaccinated till now without knowing their Inherited Real Risks, for example, of Autism (ASD), Rett syndrome, Hunter syndrome, a.s.o (1-4). Thanks to Quantum Biophysical Semeiotic, physicians can bedside recognize all the heritable risks in the envolved mothers (100%) and eliminate them with Reconstructing Mitochondrial Quantum Therapy (5), before the onset of pregnancy or in children immediately after birth. I think, to achieve significant, momentous goals in pre-primary and primary prevention not always researchers, regardless of theit countries, need funds. Despite the resources obtained, the researchers, have not been able to stop today’s growing epidemics of CVD, T2DM, and Cancer especially because of overlooking related Inherited Real Risks and how removing them.
As a matter of facts, the discovery without any cost of CVD/CAD, T2DM, and Cancer Inherited Real Risks, recognized from individual’s birth with a common stethoscope and removed by not expensive therapy (5) did not bring still great success. The explanation of this distressing event deserves an urgent explanation, in my opinion. Speaking frankly, I do not think that today famous PGs of peer-reviews, as PLoS, can spread knowledge of Medicine that belong to 2050. Let us think that, according to the present Weltanschauung of Medicine, the water of human body (approximately about 80 percent of the brain total weight) is stationary, rather than vibrating in a coherent way! In addition, among physicians and Editors, nobody knows that it does really exist non-local realm in biological system beside the local one (www.sisbq.org). Interestingly, to bedside recognize in one second cancerous areas (Cancer Inherited Real Risk) of all biological systems, although very limited, physicians could use firstly Terziani’s Maneuver, so that in a few minutes, they would be able to bedside recognize the individuals affected by cancer, a long time before diseases symptomatology occurs.
References.
1) Sergio Stagnaro and Simone Caramel. BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention. Front. Genet. | doi: 10.3389/fgene.2013.00039. http://www.frontiersin.or… [MEDLINE]
2) Sergio Stagnaro and Simone Caramel. The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.or… [MEDLINE]
3) Sergio Stagnaro and Simone Caramel. Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology,. 2013; 4: 17. http://www.frontiersin.or… [Medline]
4) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Front Endocrinol (Lausanne). 2013; 4: 17. Published online 2013 Feb 26. doi: 10.3389/fendo.2013.00017[Medline]
5) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g…[MEDLINE]
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http://journals.plos.org/plosmedicine/article/comment?id=10.1371/annotation/2f35009a-1937-4aca-b1d6-da6ec14cdb09
The essential problem in the protection of subjects against CAD and AMI is to enrich the physical examination with the search for Caotino’s Sign, which allows physician to recognize at the bed-side the Inherited Real Risk of CAD, with or without predisposition to myocardial infarction, using a common stethoscope (1-3).
1) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. Internaional Atherosclerosis Society. http://www.athero.org, 29 April, 2009 http://www.athero.org/commentaries/comm907.asp
2) Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php
3) Sergio Stagnaro and Simone Caramel (2013). The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., [MEDLINE]
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http://journals.plos.org/plosmedicine/article/comment?id=10.1371%2Fannotation%2F83844e90-c050-4140-8f74-52a1af212611
In my opinion, to preventing the most common and deadly disorders in both underdeveloped and developed countries, competent health Authorities must take into account the central role played by the Pre-Primary and Primary Prevention of the most common and dangerous human pathologies, which depends clearly by easy and quick bed-side detecting individuals involved by relative Constitution-Dependent, Inherited Real Risks, e.g., of CVD/CAD, T2DM, Cancer (1-4).
In order to define clinically a particular constitution, which does not exclude the presence of other ones, it is necessary to think over the current possibility of gathering at the bed-side biophysical-semeiotic data, rich of biological and molecular-biological information on the various human organs, tissues and apparatus, so that doctor can describe numerous types of constitutions, even from the quantitative point of view. Without any doubt, these data cannot be observed at all by the aid of traditional physic semeiotics, unable of carrying molecular-biological events to clinical dimension, which really represents the most original and fertile aspect of Quantum Biophysical Semeiotics (5). Not to speak, obviously, of sophysticated semeiotics, expensive and unable to be applied on large scale. I am sure that it represents a new medical “Weltanschauung”, which, therefore, needs open-minded physicians at the “peer-reviews”, nowadays, unfortunately, very seldom to be find.
References.
- Sergio Stagnaro and Simone Caramel (2013). The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., [MEDLINE]
- Sergio Stagnaro and Simone Caramel. BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention. Genet. | doi: 10.3389/fgene.2013.00039. http://www.frontiersin.org/Cancer_Genetics/10.3389/fgene.2013.00039/full [MEDLINE]
- Sergio Stagnaro and Simone Caramel. The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.org/Epigenomics_and_Epigenetics/10.3389/fgene.2013.00055/full [MEDLINE]
- Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [MEDLINE]
- Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
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http://journals.plos.org/plosone/article/comment?id=10.1371/annotation/bb1e8795-6a6d-45f6-914c-eb49fefe8ac5
Autism Inherited Real Risk is based on mitochiondrial heritable Dysfunction
Posted by Stagnaro on 09 Dec 2017 at 10:46 GMT
Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism is really associated with Autism Inherited Real Risk (1-3). Considering that all Inherited Real Risks are eliminated with medical therapy (Quantum Therapy), I foresee that the diagnosis of Autism Inherited Real Risk in women before the beginning of pregnancy will prevent ASD.
References.
1) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Auscultatory Percussion of the Stomach Plays a Central Role in Bedside Diagnosis and Primary Prevention of Neurodegenerative Diseases and their Inherited Real Risks. 5th Annual World Congress Neotalk, Nijang, China, http://www.bitlifescience…
2) Sergio Stagnaro. Il Reale Rischio Congenito di Autismo. L’Iter diagnostico Semeiotico-Biofisico-Quantistico. Libri e Articoli, http://www.sisbq.org/uplo…
3) Stagnaro Sergio. Inherited Real Risk of Brain Disorders. www.plos.org, 24 July 2009. http://www.plosone.org/ar…
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http://journals.plos.org/plosmedicine/article/comment?id=10.1371%2Fannotation%2F494bf186-c490-4bf7-98a2-eb97f45c4f72
Diabetic Constitution-Dependent, Inherited Real Risk. Osteocalcin Test.
Posted by Stagnaro on 04 Dec 2016 at 08:11 GMT
Among the different, Quantum Biophysical Semeiotic signs useful for the diagnosis of Diabetic Constitution-dependent, Inherited Real Risk of T2DM, as well as all Five Stages, including the overt T2DM, utilizing the pancreatic gastric aspecific reflex (1-5), I illustrate briefly the Osteocalcin Test (2). This original manoeuvre, based on a singular activity of osteocalcin, is reliable in bedside detecting diabetes in 1 min, with the aid of a common stethoscope. In fact,
osteocalcin, a product of osteoblasts, among other action mechanisms, stimulates both insulin secretion and insulin receptor sensitivity (1-5).
As a consequence, osteocalcin, secreted by the bone cells during mean-intense (i.e., 700 dyne/cm2) lasting digital pressure?for instance?applied upon lumbar vertebrae, brings about increasing pancreatic diameters, i.e., technically speaking, type I, associated, Langherans islet microcirculatory activation. By this way, doctors assess pancreas size augmentation, which in health, lasts 10 sec. exactly. After that, pancreas diameters return to its basal value for 3 s. The second pancreas size increasing lasts 20 s, and finally the third one shows the highest value: 30 sec.
On the contrary, in case of diabetic constitution the first pancreas increasing persists normally (10 sec.), but both the second and the third dilations are less than the physiological one (i.e., less than 20 s and respectively 30 s). In presence of intense IRR of T2DM, such as impairment is greater. Finally, in case of T2DM the alteration is present already in the first evaluation, wherein duration appears less than 10 s, inversely related with disorder seriousness.
1) Stagnaro S. (2002). Diet and risk of type 2 diabetes. N. Engl. J. Med. 346, 297?298 [PubMed]
2) Sergio Stagnaro and Simone Caramel (2013). Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology. 26 February 2013 | http://dx.doi.org/10.3389… http://www.ncbi.nlm.nih.g…[MEDLINE]
3) Stagnaro S., Caramel S. (2013). The role of modified mediterranean diet and quantum therapy in type 2 diabetes mellitus primary prevention. JPNAS 3, 59?70
4) Simone Caramel, Marco Marchionni and Sergio Stagnaro. The Glycocalyx Bedside Evaluation Plays A Central Role in Diagnosing Type 2 Diabetes Mellitus and in its Primary Prevention. Treatment Strategies – Diagnosing Diabetes, Cambridge Research Centre, Volume 6 Issue 1, Pg 41-43. http://viewer.zmags.com/p…
5) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. https://www.researchgate….
http://www.ncbi.nlm.nih.g… [MEDLINE]
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——– Messaggio Inoltrato ——–
| Oggetto: |
My comments cancelled! Shame. |
| Data: |
Sun, 10 Jul 2016 07:53:24 +0200 |
| Mittente: |
Sergio Stagnaro <dottsergio@semeioticabiofisica.it> |
| A: |
plosbiology@plos.org, plosmedicine@plos.org, plosone@plos.org |
| CC: |
SISBQ mailing list <sisbq_medicaldoctors@yahoogroups.com> |
Dear PLOS Editors,
For a long time, due to technical problems regarding my Username and Password, I have been trying to comment papers, published on PLOS journals, with your HELP. Do you remember, don’t you? Finally, I succeded in sending my comments (Attachment).
Surprisingly, I realize thal all my comments are cancelled without reason after some days.
I admitt my English is poor, but I cannot imagine that also PLOS Editors accept and publish only comments politically correct.
Never mind! I will survive even without sending you further cricitics.
I thank you in any case because you highlight and explain what accounts for the reason CVD/CAD, T2DM, Osteoporosis and Cancer are growing epidemics.
A gift to you: Sergio Stagnaro. Riflesso Muscolo Scheletrico-Gastrico Aspecifico: Strumento Clinico affidabile nella Diagnosi di Diabete Mellito tipo 2 e Osteoporosi. www.sisbq.org, Libri e Articoli, http://www.sisbq.org/uploads/5/6/8/7/5687930/riflessomuscoloscheletrico_agg2016.pdf
Sergio Stagnaro
Sergio Stagnaro MD
Via Erasmo Piaggio 23/8,
16039 Riva Trigoso (Genoa) Italy
Phone 0390-0185-42315
Founder of Quantum Biophysical Semeiotics,
Honorary President of International Society of
Quantum Biophysical Semeiotics (SISBQ)
www.semeioticabiofisica.it
www.sisbq.org
www.sergiostagnaro.wordpress.com
Overlooking ATS Constitution-Dependent, Inherited Real Risk drug Effect on Carotid Artery Atherosclerosis cannot be ascertain.
Posted by Stagnaro on 05 Jul 2016 at 15:31 GMT
Without CVD Inherited Real Risk, the numerous environmental risk factors of ATS are innocent bystanders (1-5). As a consequnce, the Authors have to enrolle in this type of research exclusively diabetics, involved by CVD Inherited Real Risk. As a matter of facts, only a percentage of T2DM shows artery disorder, atherosclerotic in nature, but not all.
References.
1) Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology. http://www.fac.org.ar/qcv…
2) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning.International Atherosclerosis Society. www.athero.org, 29 April, 2009 http://www.athero.org/com…
3) Stagnaro Sergio. Bedside Evaluation of CAD biophysical-semeiotic inherited real risk under NIR-LED treatment. EMLA Congress, Laser Helsinki August 23-24, 2008. “Photodiagnosis and photodynamic therapy”, Elsevier, Vol. 5 suppl 1 august 2008 issn 1572-1000.
4) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., European Journal of Clinical Nutrition 67, 683 (June 2013) | doi:10.1038/ejcn.2013.37, http://www.nature.com/ejc… [Medline]
5) Pyatakovich F.A., Stagnaro S., Caramel S., Yakunchenko T.I., Makkonen K.F., Moryleva O.N. Background Millimeter Radiation Influence in Cardiology on patients with metabolic and pre-metabolic syndrome. Journal of Infrared and Millimeter Waves, , Shanghai, China
http://journal.sitp.ac.cn…
Second Comment:
ATS-Dependent and T2Diabetes Mellitus-Dependent Inherited Real Risks are different.
In my opinion, if ATS Constitution-Dependent, Inherited Real Risk really exists (1-4), and it is not the same as the diabetic (5), the data of this research are fundamentally biased. As a matter of facts not all diabetics are suffering for CVD. Aiming to assess properly risks and population burden of Cardiovascular Diseases Associated with Diabetes the Authors have to enroll in their research exclusively diabetics involved also by ATS Constitution-Dependent, Inherited Real Risk.
References.
1) Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology. http://www.fac.org.ar/qcv…
2) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning.International Atherosclerosis Society. http://www.athero.org, 29 April, 2009 http://www.athero.org/com…
3) Stagnaro Sergio. Bedside Evaluation of CAD biophysical-semeiotic inherited real risk under NIR-LED treatment. EMLA Congress, Laser Helsinki August 23-24, 2008. “Photodiagnosis and photodynamic therapy”, Elsevier, Vol. 5 suppl 1 august 2008 issn 1572-1000.
4) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., European Journal of Clinical Nutrition 67, 683 (June 2013) | doi:10.1038/ejcn.2013.37, http://www.nature.com/ejc… [Medline]
5) Sergio Stagnaro and Simone Caramel. Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology. Front Endocrinol (Lausanne). 2013; 4: 17. Published online 2013 Feb 26. doi: 10.3389/fendo.2013.00017http://www.frontiersin.org/Review/ReviewForum.aspx [Medline]
PS. If also this comment will be cancelled, I’ll loose not my time, sending further comments!
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Early bedside diagnosis of pancreas cancer is easy
Posted by Stagnaro on 04 Jul 2016 at 07:30 GMT
The best of all therapies is notoriously Primary Prevention.
There is a general agreement among the Authors around the world that Pancreas Cancer diagnosis, especially in initial, symptomless stages, first of all, Inherited Real Risk, is really difficult, if possible. Notoriously such a malignancy is known as “the silent killer”.
I suggest you to PLOS Editors to write an Editorial on this topic, which will be really interesting.
Despite my poor English, I can provide them with pleasure my technical support, whose scientific value is surely of paramount level, as demonstrates the mail of Scientific Committee of Marseille Symposium, 2014, I can send them if they want it.
References.
Sergio Stagnaro. Early bedside Diagnosis of Pancreas Cancer, starting from its Oncological Terrain-Dependent, Inherited Real Risk http://www.sisbq.org/uplo… Slide Presentation at URL http://www.sisbq.org/uplo…
Sergio Stagnaro (2015). Thanks to Quantum Biophysical Semeiotics, Stating that the Diagnosis of Pancreas Cancer is difficult, especially in the early, asymptomatic stages , is false since July 3, 2015.
https://sergiostagnaro.wo…
Sergio Stagnaro. Originale Ruolo svolto dai PPAR?-1 nella Diagnosi Clinica di Cancro del Pancreas a partire dal suo Reale Rischio Congenito. La Voce di SS., www.sergiostagnarowordpre… http://www.sisbq.org/uplo…________________________________________________________________________
CANCELLED
The best way to do a research
Posted by Stagnaro on 05 Dec 2015 at 08:49 GMT
Despite a flurry of paramount researches, performed in famous Universities and National Institutes, CVD, T2DM, Osteoporosis and Cancer are today’s growing epidemics. There is something grossly wrong in the current way of conducting researches and describing their data. For instance, there is a general agreement among the Authors worldwide that pancreas cancer diagnosis, especially in its symptomless stages, is very difficult, if possible, in the course of decades, when therapeutic results would be surely better. As a consequence, such a cancer has been termed as “the silent killer”. On the contrary, bedside pancreas cancer is really easy for the physicians skilled in Quantum Biophysical Semeiotic, starting from its Inherited Real Risk. In my opinion, it’s tragic that these studies, although useful to humankind, cannot be published on the famous peer-reviews, spreading widely among doctors.
1) Sergio Stagnaro. Stagnaro’s *Sign in detecting every gastrointestinal Disorder, even initial or symptomless. http://www.sisbq.org/uplo…
2) Sergio Stagnaro (2015). Terziani’s Maneuvre in early recognizing cancer from its first stage, Inherited Real Risk. www.sisbq.org, http://www.sisbq.org/uplo…
3) Sergio Stagnaro (2015). Early bedside Diagnosis of Pancreas Cancer, starting from its Oncological Terrain-Dependent, Inherited Real Risk http://www.sisbq.org/uplo… ;
Slide Presentation at URL http://www.sisbq.org/uplo…
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Every possible risk factor acts upon Parkinson Constitution-Dependent Inherited Real Risk.
Posted by Stagnaro on 11 Aug 2015 at 15:45 GMT
Mitochondria dysfunction are essential in the pathogenesis of both T2DM and Parkinson’s Inherited Real Risk (1-%)
Quantum Biophysical Semeiotic (QBS) theory offers an approach “as a whole” of the patho-physiology of inherited mitochondrial neurodegenerative diseases, as well as that of PD, characterized by an Inherited Real Risk (IRR) of Brain Disorders (3,4). In the frame of QBS theory, the combination of Clinical Microangiology and “Angiobiopathy” theory (1), allows to merge the hypothesis of PD as neurological microvascular-based disease and the researches focused on mitochondrial dysfunction according to the inherited genetic causes of this neurodegenerative pathology, i.e., the congenital alteration of mit-DNA in related neuronal cells. QBS is a new discipline in medical field and an extension of the classical medical semeiotics with the support of quantum and complexity theories. It is a scientific trans-disciplinary approach that is based on the “Congenital Acidosic Enzyme-Metabolic Histangiopathy” (CAEMH) (1-5), a unique mitochondrial cytopathy that is present at birth and subject to medical therapy. The presence of intense CAEMH in a well-defined area (i.e., pre-Rolandic area) is due to gene mutations in both n-DNA and mit-DNA. This is the basis for one or more QBS constitutions, which could bring about their respective IRR (1-5).
The Quantum BS method allows the clinical and pre-clinical diagnosis of the most severe diseases such as the IRR of brain disorders including PD; this is achieved in the easier way through the auscultatory percussion of the stomach . Made with the aid of gastric aspecific reflex, this diagnosis is consistent and dually reflects the informative nature and quality of parameters collected by QBS microcirculatory investigations. The patho-physiology of QBS reflexes is based upon local microvascular conditions. In case of genetic alteration of both DNAs, intense CAEMH, and IRR of Brain Disorders there is a microcirculatory remodeling, especially intense under environmental risk factors, due to vasomotility and vasomotion impairment (e.g., functional imperfection) and structural obstructions, i.e., pathological Endoarteriolar Blocking Devices (EBDs) and Arteriovenous Anastomosis (AVA) (Stagnaro, 2009c). According to QBS, most of these inherited impairments are already present, in a similar form, in micro-vascular neurobiological systems and clinically observable since birth, through ureteral reflexes diagnosis. Briefly, in healthy, from the microcirculatory point of view, during stress test both vasomotility (chaotic-deterministic oscillations of arterioles) and vasomotility (chaotic deterministic fluctuations of nutritional capillaries and post-capillary venules) are maximally activated, particularly in parietal cerebral regions. On the contrary, in individuals with a family history positive for PD and, of course, in patients in the first stages of AD, under identical conditions a dissociated form of microcirculatory activation appears, characterized by increased vasomotility and decreased vasomotion. The flow- and flux-motion in the cerebral microcirculatory bed appears to be clearly decreased, due to the dangerous phenomenon of the so-called “microcirculatory blood-flow centralization.” Every environmental risk factor has to act upon such a Inherited Real Risk of PD.
References.
1) Stagnaro Sergio. Depression, anxiety, and psychosis in Parkinson’s Disease. BC Medical Journal Volume 43, Number 6, July/August 2001, page 321, 200.
2) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease Primary Prevention. Letter to the Editor, The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/… [MEDLINE]
3)Sergio Stagnaro. A fundamental bias of the research: Overlooking Congenital Acidosic Enzyme-Metabolic Histangiopaty-Dependent Brain Inherited Real Risk. Journal of Neurology, Neurosurgery & Psychiatry with practical Neurology, 5 May, 2009. http://jnnp.bmj.com/conte…
4) Marco Marchionni, Simone Caramel, Sergio Stagnaro. Inherited Real Risk of Alzheimer’s Disease: bedside diagnosis and primary prevention.Frontiers in Neuroscience, in http://www.frontiersin.or… [MEDLINE]
5) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Auscultatory Percussion of the Stomach Plays a Central Role in Bedside Diagnosis and Primary Prevention of Neurodegenerative Diseases and their Inherited Real Risks. 5th Annual World Congress Neotalk, Nijang, China,
http: //www.bitlifesciences.com/n…
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Bedside easy diagnosis of pancreas cancer starting with its Inherited Real Risk
Posted by Stagnaro on 05 Aug 2015 at 06:24 GMT
Sirs, there is now a general agreement among the Authors around the world that Pancreas Cancer diagnosis, especially in initial, symptomless stages, is really difficult. However, when phisicians will be able to bedside recognize the entire symptomatology of pancreas cancer, including its Oncological Terrain-Dependent, Inherited Real Risk, such a diagnosis will be really easy from individual’s birth. Finally, the inhexpensive Quantum Therapy removes this predisposition to the till now deadly pancreas cancer. (1, 2)
References.
1)Sergio Stagnaro (2015). Early bedside Diagnosis of Pancreas Cancer, starting from its Oncological Terrain-Dependent, Inherited Real Risk http://www.sisbq.org/uplo…
2)Sergio Stagnaro (2015). Thanks to Quantum Biophysical Semeiotics, Stating that the Diagnosis of Pancreas Cancer is difficult, especially in the early, asymptomatic stages , is false since July 3, 2015.
https://sergiostagnaro.wo…
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http://speakingofmedicine.plos.org/2010/01/14/this-week-in-plos-medicine-bat-influences-eu-policies-spread-of-mrsa-mapped-across-europe-role-of-national-health-systems-in-global-health-discussed/#comment-871
Sergio Stagnaro, on January 14th, 2010 at 9:30 pm Said:
Medicine is Maid of Economics. As a consequence, physicians ignore the advances, clinical in nature, among these a central role is played by Quantum Biophysical Semeiotic Constitutions. For instance, tobacco smoking facilitate diabetes onset, but evidently in NOT all individuals, because subjects without such as predisposition will never be involved by diabetes. Analogously, exclusively individuals positive for Oncological Terrain “and” Inherited Real Risk of lung cancer, possibly will suffer for lung cancer, under negative effect of cigarette smoking.
To be continued…
