Semeiotica Biofisica Quantistica. Il Nuovo Rinascimento della Medicina.

In the past I have discovered and described 35 quantum-biophysical-semeiotic signs, which the physician experienced in Quantum Biophysical Semeiotics can quickly and easily use to diagnose Inherited Real Risk of CAD starting from birth (1-35).

Below I, 90 year-old, describe the 36 sign of Inherited Real Risk of CAD, diagnosed from birth with a stethoscope and eliminated, more solito, with Restructuring Mitochondrial Quantum Therapy, /7/5687930/tq_englishversion.pdf

Today a few physicians are able to use this sign, knowing not only Quantum Biophysical Semeiotics (36), but also Clinical Microangiology (37) and Psychokinetic Diagnostics (38, 39).

Despite the difficulty of the sign, I describe it because the difficulty in today will be routine in tomorrow.

Variant Krogh’s Sign.

This fascinting sign, really reliable, allows physicians to detect at the bed-side the Inherited Real Risk of CAD an AMI in a few seconds.

Analogously to what I have discribed about Classic Krog Sign (40), regarding large artery obstruction, starting from the very initial stage, i.e., from birth, in presence of Inherited Real Risk of CAD, the intense pressure (1,000 dyne/cm.2) applied upon right and than left coronary artery, performde by means of the thought, according to Psychokinetic Diagnostics (38, 39), brings about downstream microcirculatory events really important from the diagnostic view-point.

In the health, under th above. described circumstances, the downstream microcirulation simultaneously shows Microcirculatory Activation, Associated, type I, so that the diastole duration of the local periheral heart, according to C. Allegra (37), rises from 6 sec. to 12 sec. at rest.

On the contrary, in presence of CAD IRR such a microcirculatory activation happens after at least 3 sec. Latency Time and the diastole duration rises at 10 sec. or less.


I dedicate this sign to August Krogh, Nobel Prize in Physiology or Medicine 1920, for his excellent studies on microcirculation.


1)  Sergio Stagnaro and Simone Caramel (2012) Quantum Biophysical Semeiotics Microcirculatory Theory of Arteriosclerosis, Journal of Quantum Biophysical Semeiotics, first version,

2) Sergio Stagnaro, Use of multiple markers and improvement of the prediction model for cardiovascular mortality,, 21 May, 2008

3)   Stagnaro Sergio.    CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. International Atherosclerosis Society., 29 April, 2009, ;

   4) Sergio Stagnaro   (29 May 2008) Bedside Recognizing CAD Inherited Real Risk and silent CAD with Biophysical Semeiotics.

5) Sergio Stagnaro  Bed-side biophysical semeiotic recognizing CAD “inherited real risk” and overt CAD, event silent. l: (18 October 2003).,

6) Sergio Stagnaro Assessing NK cell compartment in individuals with CAD Inherited Real Risk. Immunity & Aging, (14 May 2007),  

7) Sergio Stagnaro.  Bedside Biophysical-Semeiotic Recognizing CAD Real Risk and silent CAD. Journal Review,

8)  Sergio Stagnaro.  A Clinical Biophysical-Semeiotic Contribution reliable in prompt recognizing CAD, even silent. BMC.Cardiovascular Disorders, 2005,

9)    Sergio Stagnaro. Without CAD Inherited Real Risk, All Environmental Risk Factors of CAD are innocent Bystanders. Canadian Medical Association Journal.CMAJ, 14 Dec 2009, 

10)  Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology, 2007.

11)  Sergio Stagnaro.  A Clinical Method far better than Blood Cell Count in CAD Primary Prevention., 2005, 

12)  Sergio Stagnaro.    Biophysical Semeiotics is really useful in order to bed-side recognizing heart ischaemic disease, even before its onset, i.e., real risk of coronary artery disease. BMC. Cardiovascular Diseases, 2004,

13) Stagnaro Sergio. Bedside Evaluation of CAD biophysical-semeiotic inherited real risk under NIR-LED treatment. EMLA Congress, Laser Helsinki August 23-24, 2008. “Photodiagnosis and photodynamic therapy”, Elsevier, Vol. 5 suppl 1 august 2008 issn 1572-1000

14) Sergio Stagnaro    Biophysical-Semeiotic Diagnosing Cad “real” risk, as well as pre-clinical and clinical CAD., (12 September 2003)

15)   Sergio Stagnaro   Bedside Biophysical Semeiotic Evaluation of Acute Phase Proteins. Ann Family Med. 2008, 

16)    Sergio Stagnaro.    EBM “and” Single Patient Based Medicine, Medical News today, 2007,

17) Sergio Stagnaro. Inherited Real Risk of CAD and Cancer,, 2008,

18) Sergio Stagnaro (2012).  I Segni di Caotino* e di Gentile** nella Diagnosi di Reale Rischio Congenito di CAD e di Infarto Miocardico, ancorché iniziale o silente. Fisiopatologia e Terapia. Lectio Magistralis. III Convegno della SISBQ, 9-10 Giugno 2012, Porretta Terme (Bologna).; English version:

19) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory,, Roma, 2009.

20) Simone Caramel and Sergio Stagnaro (2012).   Vascular calcification and Inherited Real Risk of lithiasis. Front. In Endocrin.  3:119. doi: 10.3389/fendo.2012.00119  [MEDLINE].

21) Sergio Stagnaro and Simone Caramel.  The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics.  [MEDLINE]

22) Sergio Stagnaro (2013).   Two Clinical Evidences corroborating Microcirculatory QBS Theory of Atherosclerosis.Lectio Magistralis, IV Meeting of Quantum Biophysical Semeiotics International Society, May 4-5, 2013, Porretta Terme, Bologna, Auditorium, Hotel Santoli. Journal of QBS,

23) Sergio Stagnaro (2013).   Abdominal Aortic Aneurism Inherited Real Risk: Patho-Physiology, Quantum-Biophysical-Semeiotic Symptomatology, Diagnosis and Therapy. Journal of Quantum Biophysical Semeiotics.

24) Sergio Stagnaro, Simone Caramel. Inherited Real Risk of Coronary Artery Disease: pathophysiology, diagnosis and primary prevention. Epidemiology and Cardiovascular Prevention. Brief Communication. 8th International Congress of Cardiology in the internet. Published: 28 October 2013. FAC Federaciòn Argentina de Cardiologia   – PDF

25)  Sergio Stagnaro. CAD Inherited Real Risk In Preventing Myocardial Infarct., 13 September, 2010.

26) Sergio Stagnaro. Reale Rischio Congenito di Infarto miocardio. Fondamentali Aspetti Teorici, 2014.,

29) Sergio Stagnaro. Il Reale Rischio Congenito di Infarto Miocardico: Fisiopatologia, Diagnosi e Terapia. Il Ruolo centrale svolto dal Diabete Mellito Tipo 2 Stagnaro e

27) Pyatakovich F.A., Stagnaro S.,   Caramel S., Yakunchenko T.I., Makkonen K.F., Moryleva O.N.  Background Millimeter Radiation Influence in Cardiology on patients with metabolic and pre-metabolic  syndrome. Journal of Infrared and Millimeter Waves, , Shanghai, China

28)  Simone Caramel (2010). Coronary Artery Disease and Inherited Real Risk of  CAD.  Journal of Quantum Biophysical Semeiotics.

29) Sergio Stagnaro, Simone Caramel. Inherited Real Risk of Coronary Artery Disease: pathophysiology, diagnosis and primary prevention.Epidemiology and Cardiovascular Prevention. Brief Communication. 8th International Congress of Cardiology in the internet. Published: 28 October 2013. FAC Federaciòn Argentina de Cardiologia   – PDF

30) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., European Journal of Clinical Nutrition volume 67, page 683 (2013), [MEDLINE]

31) Simone Caramel, Marco Marchionni  and Sergio Stagnaro (2014). The Glycocalyx Bedside Evaluation Plays A Central  Role in Diagnosing Type 2 Diabetes Mellitus and in its Primary Prevention. Treatment Strategies – Diagnosing Diabetes, Cambridge Research Centre, Volume 6 Issue 1, Pg 41-43.

32) Mario Siniscalchi, Simone Caramel, Sergio Stagnaro (2016).Quando il fonendoscopio aiuta il cardiologo. Cuore e Vasi. Anno XXXVII • N. 3-4/2015, dicembre. Pg.15.

33) Sergio Stagnaro (2019). ATS Constitution-Dependent, Inherited Real Risk is the conditio sine qua non of coronary disorder, including AMI.   European Society of Cardioloy, ESC, Oxford Academic, European Heart Journal

34) Sergio Stagnaro (2016).  We can defeat CAD with or without predisposition to AMI. April 20, 2016. Comment on JAMA website.

35) Sergio Stagnaro (2019). ATS Constitution-Dependent, Inherited Real Risk is the conditio sine qua non of coronary disorder, including AMI.  European Heart Journal, Comment, 1 November 2019.

36) Sergio Stagnaro. Quantum biophysical semeiotics. NeuroQuantology | September 2011 | Vol 9 | Issue 3 | Page 459‐467.

37) Sergio Stagnaro – Marina Neri Stagnaro. Microangiologia Clinica. A cura di Simone Caramel. e-book,,

38) Sergio Stagnaro.      Psychokinetic Diagnostics, Quantum Biophysica Semeiotics Evolution. , 12 March 2010,  and

39) Sergio Stagnaro.  PSYCHOKINETIC DIAGNOSTICS, QUANTUM-BIOPHYSICAL-SEMEIOTICS EVOLUTION. Journal of Quantum Biophysical Semeiotic  Society.

40) Sergio Stagnaro (2014). Segno di Krogh: Diagnosi di AOPA a partire dal I stadio asintomatico. ;




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