In following, for the first time I illustrate an original, reliable, quantum-biophysical-sign of pancreas cancer early bedside diagnosis, starting from birth.
In my opinion, based on 65-year-long clinical experience, overlooking Quantum Biophysical Semeiotics, there is a fundamental bias in all researches, including Pancreas Cancer (1-8).
Since 20 years, I am suggesting unhearded the central role played by the Oncological Terrain-Dependent, Inherited Real Risk of pancreas cancer in pre-primary and primary prevention and treatment of such a cancer (9).
Interestingly, in the normal pancreas microcirculatory bed (or more scientifically speaking, pancreas tissue-microvascular unit), analogously to that of lung, heart, stomach, oesophagus, breast, a.s.o., there are exclusively type II, physiological, Endoarteriolar Blocking Devices (EBD), according to S.B.Curri, bedside recognized nowadays even with a stethoscope, thanks to Quantum Biophysical Semeiotics (e.g., Stagnaro’s Sign,e.g.) and Clinical Microangiology (10-12).
Numerous ureteral reflexes as well as the “simple”, advisable, from the practical viewpoint, Gastric Aspecific Reflex, allow doctor to evaluate with a common stethoscope structure and function of microcirculatory bed diverse components.Inhealth, we cannot observe newborn-pathological, type I, subtype a) oncological, and b) aspecific, EBD, but only type II EBD in small arteries, according to Hammersen, the only ubiquitous, in above-mentioned biological systems, including pancreas.
On the contrary, in individuals, positive for Oncological Terrain“and”involved by oncological or other Inherited Real Risk (e.g., pancreas, coronary, oesophagous, breast, stomach, lung, prostate cancer or inflammatory-degenerative real risk) with the aid of Biophysical Semeiotics we recognize also newborn-pathological, type I, subtype a) oncological, and/or b), aspecific, common to all other disorders,EBD, facilitating since birth the proper diagnosis of whatever inherited real risk, including pancreas cancer inherited real risk, namely the very first stage of disease, that plays a pivotal role in pre-primary and primary prevention (1-8).
This new QBS sign is based on the assesment of Low Grade Chronic Inflammation of adipose tussue always present from birth at the level of Inherited Real Risk (13-15), bedside recognized by mean of Spattini’s Sign (16).
If evaluated in the health, Spattini’s Sign shows normal parameter values, related to adipose tissue of the pancreas: Latency Time 10 sec. and Duration of Gstric Aspecific Reflex > 3sec. – 4 sec. >.
On the contrary, in patient involved by Pancreas Cancer, starting from its Inherited Real Risk, i. e., from birth, these parameter values result altered in varying degrees of intensity, in relation to the cancer stage.
For instance, in the first stage, Latency Time of Spattini’s Sign is normal, 10 sec., but the G.A.-Reflex appears pathologically prolonged: 4 sec. or more.
Authors around the world agree with the statement, the diagnosis of Pancreas Cancer is very difficult in symptomatic stage, but impossible in symptomless stages, as Oncological Terrain-Dependent, Inherited Real Risk of pancreas cancer.
Quantum Biophysical Semeiotic, specific signs (1-8) allow physician for the first time to bedside diagnosing pancreas cancer from patient’s birth, i.e., from its Inherited Real Risk.
References
1) Sergio Stagnaro. Early bedside Diagnosis of Pancreas Cancer, starting from its Oncological Terrain-Dependent, Inherited Real Risk http://www.sisbq.org/uploads/5/6/8/7/5687930/norimbergasign_pancreascancer.pdf; Slide Presentation at URL http://www.sisbq.org/uploads/5/6/8/7/5687930/cancropancreas_2015.pdf
2) Sergio Stagnaro. Veronesi’s Sign: Bedside diagnosing Pancreas Cancer from Birth, i.e., its Inherited Real Risk. http://www.sisbq.org/uploa…/5/6/8/7/5687930/veronesisign.pdf
3) Sergio Stagnaro. Iter Diagnostico del Cancro Pancreatico ad iniziare dal suo Reale Rischio Congenito, dipendente dal Terreno Oncologico. http://www.sisbq.org/uploads/5/6/8/7/5687930/iterdiagnosticocancropancreas.pdf; https://dabpensiero.wordpress.com/2018/06/22/iter-diagnostico-del-cancro-pancreatico-ad-iniziare-dal-suo-reale-rischio-congenito-dipendente-dal-terreno-oncologico/
4) Sergio Stagnaro. Originale Ruolo svolto dai PPARγ-1 nella Diagnosi Clinica di Cancro del Pancreas a partire dal suo Reale Rischio Congenito. La Voce di SS., http://www.sergiostagnarowordpress.com, http://www.sisbq.org/uploads/5/6/8/7/5687930/ppars_diagnosicancropancreas2015.pdf
5) Sergio Stagnaro. Reale Rischio di cancro al pancreas: fisiopatologia, diagnosi e prevenzione primaria”. Lectio Magistralis . Corso di Formazione in SBQ, Porretta Terme, Auditorium Hotel Santoli, 21 Maggio 2016, https://www.youtube.com/watch?v=lpOW79s7dho&feature=youtu.be
6) Sergio Stagnaro. Appunti di uno Studente di Medicina del 2050. Il Reale Rischio Congenito di Cancro del Pancreas, disattivato e attivato. http://www.sisbq.org/uploads/5/6/8/7/5687930/rrccancropancreas_attivato_disattivato.pdf
7) Sergio Stagnaro. Diagnosi Clinica del Tumore del Pancreas, a Partire dallo Stadio di Reale Rischio Congenito. www.altrogiornale.org, 4 dicembre 2011,
http://www.altrogiornale.org/news.php?item.6612.11
8) Stagnaro Sergio. Bedside diagnosing Pancreas Cancer, even in its inherited real Risk. Cases Journal. 2008, October. https://casesjournal.biomedcentral.com/articles/10.1186/1757-1626-1-280/comments
9) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, 2009.
10)Sergio Stagnaro. Introduzione alla Microangiologia Clinica 10 dicembre 2011. www.sisbq.org, http://www.sisbq.org/uploads/5/6/8/7/5687930/mc_intro.pdf
11) Sergio Stagnaro – Marina Neri Stagnaro. Microangiologia Clinica. 2016. A cura di Simone Caramel. e-book, http://www.sisbq.org,
12) Sergio Stagnaro. Compendio di Microangiologia Clinica, Connettomologia Neuronale e Non-Neuronale, Reali Rischi Congeniti, base della Prevenzione Pre-Primaria e Primaria, secondo la Semeiotica Biofisica Quantistica. http://www.sisbq.org/uploads/5/6/8/7/5687930/compendio_mc.pdf
13) Sergio Stagnaro. Ruolo del Tessuto Adiposo della Mammella nell’Insorgenza del Cancro del Seno. www.sisbq.org. http://www.sisbq.org/uploads/5/6/8/7/5687930/tessuto_adiposo_cancro_mammella_2014.pdf
14) Sergio Stagnaro. Articoli su Tessuto Adiposo della Mammella. Ruolo del Tessuto Adiposo della Mammella nell’Insorgenza del Cancro del Seno. http://www.sisbq.org/uploads/5/6/8/7/5687930/tessuto_adiposo_cancro_mammella_agg9_.pdf
15) Sergio Stagnaro. Il Tessuto Adiposo Bianco Sottocutaneo e Periviscerale di Tipo B, secondo la Semeiotica Biofisica Quantistica, è un sensore di CVD, T2DM e Cancro http://www.sisbq.org/uploads/5/6/8/7/5687930/tessutoadipososensore.pdf
16) Sergio Stagnaro. Il Segno di Spattini Svolge un Ruolo Centrale nella Diagnostica Semeiotico-Biofisico-Quantistica. http://www.sisbq.org/uploads/5/6/8/7/5687930/ilsegnodispattini.pdf;
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