|“Vivi le domande ora. Forse poi, in qualche giorno lontano nel futuro, inizierai gradualmente, senza neppure accorgertene, a vivere a tuo modo nella risposta.”
RAINER MARIA RILKE
As shows Oncological Terrain-dependent, Inherited Real Risk, tumour microcirculation differs from that of normal tissues, from Cllinical Microangiology point of view (1-4).
Authors observed that elevation of blood pressure produced a several-fold increase in tumour blood flow without increasing blood flow in normal tissue(5). These results indicate that the delivery of systemically administered anticancer drugs could be selectively enhanced in tumour tissues by induced hypertension. Unfortunately, no one has ever thought to use the different microcirculatory behaviour in cancer for diagnostic and differential diagnostic purposes (6-10).
Recent advances have improved our understanding of the renin-angiotensin system (RAS). These have included the recognition that angiotensin (Ang 1-7) is a biologically active product of the RAS cascade. The identification of the ACE homologue ACE2, which forms Ang-1-7) from Ang II, and the GPCR Mas as an Ang-1-7 receptor have provided the necessary biochemical and molecular background and tools to study the biological significance of Ang-1-7 (5-7).
Most available evidence supports a counter-regulatory role for Ang-1-7 by opposing many actions of Ang II on AT₁ receptors, especially vasoconstriction. Many studies have now shown that Ang-1-7 by acting via Mas receptor exerts inhibitory effects on inflammation and on vascular and cellular growth mechanisms.
The homogeneous data of my ongoing research, observed on 23 individuals of both sexes, aged from 12 to 44 years, taken together, may help in paving the original way, microcirculatory in nature, for the development of novel diagnostic and differential diagnostic procedure for cancer, starting from its initial stage of Oncological Terrain-dependent, Inherited Real Risk.
In previous artiches, I have developed the clinical evaluation of the RAS, demonstrating the real reliability of Quantum-Biophysical-Semeiotics in both diagnostic and researc (13).
Interestingly, due to the presence of no local realm in all biological systems, in one second doctors, skilled in Quantum-Biophysical-Semeiotics , may bedside recognize any disorders in urinary tract by means of Pollio’s Sign (13, 14).
In healthy, intense (1.000 dyne/cm.2) cutaneous pinching of kidney trigger-points does not bring about simultaneously the Gastric Aspecific Reflex (Fig- 1).
Gastro-Aspecific Reflex. In the stomach, Both fundus and body are dilated , while antral-pyloric region contracts.
On the contrary, in the presence of any disease of the urinary tract, such a reflex appears simultaneously: positive Pollio’ Sign.
Soon thereafter physicians can localize the precise site of disorder, ascertaining its real nature.
Interestingly, as regards early diagnosis of renal artery stenosis, Quantum Biophysical Semeiotics allows doctor to bedside recognize this vascular disorder of the kidney, since its initial stage of Inherited Real Risk.
Perhaps, for instance, available evidence does not clearly support one treatment approach over another for atherosclerotic renal artery stenosis. However, we must admit that patients with such a disorder are properly diagnosed exclusively a long time after initial disease onset, as in our case.
Unfortunately, all around the world, General Practitioners know only the traditional physical semeiotics, that isn’t so efficacious to allow doctor to recognize, since its first stage, Renal Artery Stenosis. Nowadays, physicians are capable to bedside recognize from birth any real risk of kidney diseases, both oncological and degenerative in nature.
In order to recognize Renal Artery Stenosis, the following easy and quick manoeuvre proved to be really effective in my long year clinical experience.
In health, doctor first of all delimits kidney area (15). Soon therafter doctor increases the pressure of stethoscope bell-piece, localized on kidney cutaneous projection area, causing kidney dilation (due to its congestion) immediately followed by kidney size reduction (due to decongestion) to its minimal value.
At this point, pressure prompt interruption causes the rapid – in 2 sec or less – return of kidney to its normal, basal size, indicating a physiological blood flow in renal artery.
On the contrary, in case of renal artery stenosis, the latency time results more than 2 sec., in relation to the severity of underlying disease.
To stimulate RAS, physician stimulates any one renal trigger point by cutaneous intense pintching, that causes renal decongestion and secretion of renin. In reality, this procedure is simultaneously followed by physiological Microcirculatory Activation, type I, associated (1, 2) in both the adrenal gland (catecholamines) and in the liver (angiotensinogen).
In whatever normal tissue, after the intense stimulation of kidney trigger points, the Latency Time of Gastric Aspecific Reflex slowly lowers. For instance, basal Liver- GA Reflex is 8 sec., and after the renal decongestion lowers to about 7 sec.
On the contrary, in the cancer, even in its real initial stage of Inherited Real Risk, latency Time of gastric aspecific reflex increases, and its augmentation is related directly to the stage, i.e. to the seriousness of disorder.
Due to obvious reasons, I do not illustrate the refined and reliable signs of Clinical Microangiology (1, 2), namely the fascinating behaviour of the peripheral heart, according to Claudio Allegra, under Vallebona’s Manoeuvre. Interestingly, these microcirculatory events represent the “Implicate Order” (D. Bohn), which underlies the clinical QBS phenomenology, illustrated above.
Importantly, the provisional but homogeneous data of an ongoing research, started recently, show the identical behaviour of chronic degenerative non-oncological tissues, as CVD, Osteoporosis, and T2DM.
If these data will be corroborated on a large scale by other Authors, the Vallebona’s Manoeuvre may help in paving another original way in clinical diagnostics.
* Manoeuvre dedicated to my unforgettable friend Enrico Vallebona,
- Sergio Stagnaro. Introduzione alla Microangiologia Clinica 10 dicembre 2011. www.sisbq.org, http://www.sisbq.org/uploads/5/6/8/7/5687930/mc_intro.pdf
- Sergio Stagnaro – Marina Neri Stagnaro. Microangiologia Clinica. A cura di Simone Caramel. e-book, http://www.sisbq.org, http://www.sisbq.org/uploads/5/6/8/7/5687930/microangiologiaclinicasbq2016.pdf.
- Stagnaro Sergio.Reale Rischio Semeioticso Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, 2009.
- Sergio Stagnaro and Simone Caramel. BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention. Front. Genet. | doi: 10.3389/fgene.2013.00039. http://www.frontiersin.org/Cancer_Genetics/10.3389/fgene.2013.00039/full [MEDLINE]
- Suzuki M, Hori K, Saito S, Tanda S, Abe I, Sato H, Sato H. Functional characteristics of tumour vessels: selective increase in tumour blood flow. Sci Rep Res Inst Tohoku Univ Med. 1989 Dec;36(1-4):37-45.
- Robson Augusto Santos. Angiotensin-(1–7). Hypertension. 2014;63:1138-1147
- Simões e Silva AC, Silveira KD, Ferreira AJ, Teixeira MM. ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis. Br J Pharmacol. 2013 Jun;169(3):477-92. doi: 10.1111/bph.12159.
- Matthew J. Durand, Natalya S. Zinkevich, Michael Riedel, et al. Vascular Actions of Angiotensin 1–7 in the Human Microcirculation – Novel Role for Telomerase. Arterioscler Thromb Vasc Biol. 2016 Jun; 36(6): 1254–1262.
- Suuzuki M, Abe I, Hori K, Saito S, Sato H: Characteristic blood circulation in tumour tissue, with reference to local permeation of drug in cancer chemotherapy. In: Proceedings of the 36th annual meeting of the Japanese Cancer Association, Tokyo. Tokyo: Japanese Cancer Association, 1977, p 149.
- Suzuki M, Hori K, Abe I, Saito H: Characteristics of microcirculation in tumour. Jpn J Cancer Chemother 6 (Suppl II): 287–291, 1979.
- Stagnaro-Neri M, Stagnaro S., Valutazione clinica percusso-ascoltatoria del sistema nervoso vegetativo e del sistema renina-angiotensina, circolatorio e tessutale. Arch. Med. Int. XLIV, 17378, 1992.
- Stagnaro Sergio. Renal Artery Stenosis: bedside rapid Diagnosis even in its initial stage with Quantum-Biophysical-Semeioticss. 23 May 2009 http://sciphu.com/, http://sciphu.com/2009/05/renal-artery-stenosis-bedside-rapid.html and http://wwwshiphusemeioticsscom-stagnaro.blogspot.com/
- Stagnaro Sergio e Paolo Manzelli. L’Esperimento di Lory. Scienza e Conoscenza, N° 23, 13 Marzo 2008. http://www.scienzaeconoscenza.it//articolo.php?id=17775
- Sergio Stagnaro. Realtà Locale e Non-Locale nella Medicina del Nuovo Rinascimento. https://dabpensiero.wordpress.com/2016/06/03/realta-locale-e-non-locale-nella-medicina-del-nuovo-rinascimento/
- Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeioticsa Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeioticsa_biofisica.htm