Lettera Aperta al Presidente della Repubblica Sergio Mattarella sulla mia Lotta clinica al Cancro al Seno, Epidemia in continuo aumento.

On. Presidente della Repubblica, Sergio Mattarella,

secondo quanto riferisce il Ministero della Salute – “I numeri del cancro in Italia 2017” – il tumore al seno è la neoplasia più frequente in assoluto per incidenza nella popolazione femminile. Nel 2017, in Italia, si sono ammalate di tumore al seno circa 50.500 donne e 500 uomini (per confronto, nel 2015 le stime indicavano, rispettivamente, 48 mila e 300).

In una mia Lettera Aperta del 2011, indirizzata all’allora Presidente del Consiglio Silvio Berlusconi (1), ho scritto:

“Il cancro, incluso quello della mammella, è una epidemia in continuo aumento per ammissione delle stesse competenti Autorità dell’WHO. E’ evidente che c’è qualcosa di errato nella politica sanitaria di lotta al tumore maligno finora adottata, fondata su conoscenze mediche obsolete e sul costoso e fallimentare screening, dove la mammografia recita un ruolo centrale”.

In questa Lettera Aperta illustravo la mia lotta clinica al cancro al seno realizzata con la Prevenzione Pre-Primaria e Primaria , documentandola con miei articoli, oggi ben più numerosi (2-4)

In realtà, per poter realizzare con successo la prevenzione pre-primaria (V. Manuel’s Story alle URL http://www.sisbq.org/sbq-magazine.html e http://spagna.blogosfere.it/2011/03/il-bambino-ogm-nato-a-barcellona-e-la-manuels-story.html) e primaria di un tumore tra i più diffusi e causa di ineffabile sofferenza ed elevata mortalità, medici e competenti Autorità sanitarie devono necessariamente conoscere la costituzione oncologica, cioè il Terreno Oncologico, ed il dipendente Reale Rischio Congenito Oncologico, localizzato in un quadrante – raramente più quadranti – della ghiandola mammaria (www.semeioticabiofisica.it e www.sisbq.org).

Il Glioblastoma è l’unico tumore maligno il cui Reale Rischio Congenito non dipende dal Terreno Oncologico (5-8).

Signor Presidente, le scrivo questa lettera aperta sulla prevenzione pre-primaria e primaria del cancro mammario, con la fondata speranza di non incontrare il silenzio di Ministri della Salute, Oncologi famosi, come è accaduto fino ad oggi.

Una lunga esperienza clinica di 63 anni mi permette di affermare che la prevenzione pre-primaria e primaria del cancro del seno deve inevitabilmente essere preceduta dalla razionale selezione degli individui, di entrambi i sessi, colpiti dal Terreno Oncologico e dal dipendente Reale Rischio Congenito Oncologico, localizzato in un quadrante mammario (o più), facilmente riconoscibili e passibili di quantificazione con la Semeiotica Biofisica Quantistica.

Infatti, l’assenza del Reale Rischio Congenito Oncologico nella mammella, in un soggetto magari portatore di Terreno Oncologico, esclude la possibilità d’insorgenza del cancro del seno.

Da sempre condivido il seguente pensiero di uno tra i massimi Clinici italiani del secolo XIX:    “E’ difficile rimuovere metodi perfettamente organizzati, dalla lunga tradizione, sostenuti da nomi anche illustri, basati su un corredo dottrinario elegante ma errato; forte sotto l’aspetto politico, economico, organizzativo, finanziario, pseudo-sociale. Osiamo affrontare l’immane problema, più che nella convinzione di riuscire e risolvere, per non sentirci in colpa verso noi stessi”.(Luigi Di Bella: “Cancro: siamo sulla strada giusta?”. Edizioni Travel Factory Srl – Roma, 2001).

L’attuazione di questa originale e non costosa prevenzione pre-primaria e primaria del cancro del seno, interessante tutti i cittadini, maschi e femmine, a Rischio Reale Congenito Oncologico, localizzato alla ghiandola mammaria, necessita dell’essenziale ed attiva partecipazione dei Medici di Medicina Generale, il cui ruolo è di primaria importanza.

La Prevenzione Primaria non può essere gestita che dai Medici di Medicina Generale, ovviamente, sottolineando che la Terapia Quantistica Mitocondriale Ristrutturante (2-4), opportunamente monitorata, elimina anche gli altri Reali Rischi Congeniti, per esempio di CVD, T2DM, Reumopatie, Osteoporosi.

La dettagliata descrizione operativa e l’importanza della Prevenzione Pre-Primaria del cancro è ormai definitivamente illustrata dalla Manuel’s Story.

Le tappe della prevenzione primaria del cancro del seno possono essere, in linea generale, stabilite come segue, in attesa ovviamente del contributo definitivo delle Autorità Competenti, specializzate in questo tipo di operazioni riguardanti la pubblica salute e dei Comitati Etici (alla eventuale prevedibile obiezione riguardante la discriminazione dei cittadini positivi per il Terreno Oncologico, io, ex-portatore di costituzione oncologica, pongo la domanda: Che senso ha spendere ingenti somme di denaro in ricerche sul codice genetico e sulle mutazioni del DNA nucleare, nell’oblio del DNA mitocondriale, alla luce di una simile sospetta emarginazione?

1) In una città, Provincia o Regione, innanzitutto i Medici esperti in Semeiotica Biofisica Quantistica selezionano, rapidamente ed in modo affidabile gli individui con Terreno Oncologico e con Reale Rischio Congenito di cancro al seno, impiegando inizialmente il Segno di Rinaldi (8,9). Questi individui, resi consapevoli, e quindi motivati, dei significati, delle cause e dei fini della prevenzione, sono arruolati nella campagna di prevenzione primaria organizzata e diretta tramite le locali ASLs, in modi da stabilire con precisione;

2) Tutti i soggetti selezionati ed arruolati sono tempestivamente sottoposti alle misure preventive sia dietetiche, intendendo la dieta in senso etimologico come programma del giorno, sia terapeutiche, cioè la Terapia Quantistica Mitocondriale Ristrutturante http://www.sisbq.org/uploads/5/6/8/7/5687930/tq_italian_english_agg.pdf somministrata in dosi personalizzate, sotto monitoraggio richiesto a seconda del bisogno, fino alla scomparsa del Terreno Oncologico, e quindi del Dipendente Reale Rischio Congenito.

3) Il primo controllo clinico delle risposte alla terapia è consigliabile che sia eseguito dopo circa due settimane di terapia al fine di accertare la persistenza della scomparsa della citopatologia mitocondriale, ICAEM, alla base della costituzione oncologica, seguita dalla scomparsa del Terreno Oncologico ed infine del Reale Rischio Oncologico.

In caso di insuccesso, al momento mai osservati nella mia sperimentazione, si modificherà opportunamente la terapia con l’aggiunta di altri farmaci (somatostatina, soluzione di vitamine antiossidanti, aghi “radioattivi” in loco, inseriti nell’esatta sede del reale rischio, ed infine si potrà ricorrere all’intervento chirurgico).

4) Scomparsi gli eventi biologico-molecolari e microcircolatori che hanno motivato la prevenzione, il monitoraggio terapeutico potrà essere condotto ogni mese per tre mesi successivi, e poi in caso di successo ogni sei mesi, registrando naturalmente l’incidenza di tumore al seno in tutta la popolazione, trattata e non.

5) Dopo 5 o più anni potrà essere corroborata o falsificata l’efficacia della prevenzione primaria così instaurata, i cui benefici chiaramente sono tenuti sotto rigido controllo – monitoraggio – a partire dal suo inizio.

Le mie condizioni di salute e l’età, 86 anni, non mi permettono di partecipare attivamente alla prevenzione pre-primaria e primaria, da me suggerita, alla quale posso solo assicurare la mia competenza nella Semeiotica Biofisica Quantistica, accanto al contributo prezioso dei miei ottimi Discepoli della Società Internazionale di Semeiotica Biofisica Quantistica (http://www.sisbq.org).

Signor Presidente della Repubblica Sergio Mattarella, mi auguro, col Suo aiuto, di poter finalmente vedere l’inizio della Prevenzione Pre-Primaria e Primaria del Cancro, espressione desolante della sconfitta della Medicina e non solo della Medicina.

Con Ossequio

Sergio Stagnaro

Sergio Stagnaro MD

Via Erasmo Piaggio 23/8,

16039 Riva Trigoso (Genoa) Italy

Founder of Quantum Biophysical Semeiotics,

Honorary President of International Society of

Quantum Biophysical Semeiotics (SISBQ)

Who’s Who in the World (and America)

since 1996 to 2010

Ph 0039-0185-42315

Cell. 3338631439

http://www.semeioticabiofisica.it 

http://www.sisbq.org  

dottsergio@semeioticabiofisica.it

 

Bibliografia

1)Sergio Stagnaro. Lettera Aperta al Presidente del Consiglio Silvio Berlusconi sulla Prevenzione Pre-Primaria e Primaria del Cancro del Seno. masterviaggi.it; M.V. Anno X – Nr.  330 del 26.04.2011

http://www.masterviaggi.it/news/categoria_news/41243-prevenzione_pre-primaria_e_primaria_del_cancro_del_seno.phpSergio Stagnaro and Simone Caramel. BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention.  Genet. | doi: 10.3389/fgene.2013.00039.  http://www.frontiersin.org/Cancer_Genetics/10.3389/fgene.2013.00039/full [MEDLINE]

2) Sergio Stagnaro and Simone Caramel.The Role of Modified Mediterranean Diet and Quantum Therapy in Oncological Primary Prevention.  Bentham PG.,Current Nutrition & Food Science  ISSN (Print): 1573-4013;  ISSN (Online): 2212-3881. VOLUME: 9,  ISSUE: 1; DOI: 10.2174/1573401311309010011;

http://www.eurekaselect.com/106105/article

3) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov/pubmed/25743850[MEDLINE

4) Sergio Stagnaro. Glioblastoma: Diagnosi Semeiotico-Biofisico-Quantistica a iniziare dal suo Reale Rischio Congenito. Giugno 14, 2017,

https://dabpensiero.wordpress.com/2017/06/14/glioblastoma-diagnosi-semeiotico-biofisico-quantistica-a-iniziare-dal-suo-reale-rischio-congenito/

5) Marco Marchionni,  Simone Caramel, Sergio Stagnaro Glioblastoma: Prevenzione Pre-Primaria e Primaria con la Semeiotica Biofisica Quantistica.

http://www.sisbq.org/uploads/5/6/8/7/5687930/rccglioblastoma.pdf

6) Sergio Stagnaro. Segno di Paolo nella diagnosi semeiotico-biofisico-quantistica di Glioblastoma a partire dal Reale Rischio Congenito. http://www.sisbq.org/uploads/5/6/8/7/5687930/segnodipaolo_aggiornato.pdf

7)Sergio Stagnaro. Il Segno di Rinaldi nella Diagnosi del Terreno Oncologico di Di Bella e del Cancro, solido e liquido, in atto. II Convegno Nazionale della SISBQ, Chiusi (Siena), 28-29 maggio 2011. Versione italiana:  http://www.sisbq.org/atti-del-secondo-convegno.html, http://www.sisbq.org/uploads/5/6/8/7/5687930/rinaldisign_it.pdf ; english version:  http://www.sisbq.org/proceedings-2.html
http://www.sisbq.org/uploads/5/6/8/7/5687930/rinaldisign_eng.pdf

8) Sergio Stagnaro. Il Segno di Rinaldi nella Diagnosi del Terreno Oncologico di Di Bella e del Cancro, solido e liquido, in atto. II Convegno Nazionale della SISBQ, Chiusi (Siena), 28-29 maggio 2011. Versione italiana:  http://www.sisbq.org/atti-del-secondo-convegno.html, http://www.sisbq.org/uploads/5/6/8/7/5687930/rinaldisign_it.pdf ; english version:  http://www.sisbq.org/proceedings-2.html
http://www.sisbq.org/uploads/5/6/8/7/5687930/rinaldisign_eng.pdf

9) Sergio Stagnaro. Ordine Implicato e  Ordine Esplicato nel Segno di Rinaldi, simultaneo ed istantaneo: dal Terreno Oncologico all’Oncogenesi – www.sisbq.org,  http://www.sisbq.org/uploads/5/6/8/7/5687930/rinaldi_simultaneo_2014.pdf

Pubblicità

Un Test del sangue, Cancer SEEK, svela Otto Comuni Tumori. Dopo una Settimana calerà il solito Silenzio.

Periodicamente, come le fasi lunari, i media mondiali, veline-dipendenti, informano sulla notizia del secolo: possiamo riconoscere otto tumori maligni silenti – seno, fegato, ovaie, polmone, stomaco, pancreas, esofago e colon retto –  mediante un esame del sangue, in verità molto costoso.

https://www.medscape.com/viewarticle/891491. CancerSEEK: Blood Test That Detects Eight Common Cancers. Alexander M. Castellino, PhD. January 18, 2018.

Di seguito il mio commento inviato a Medscape, dopo che Nature lo ha cancellato!

Dr. Stagnaro Sergio

NB! Il commento è stato accettato rapidamente e messo in rete!

I’m a 86-year-old clinician and researcher, who has been working treating patients for 63 years. I think, my most paramount discovery is the Oncological Terrain-Dependent, Inherited Real Risk of cancer (1). Bedside recognized from birth, using a common stethoscope, in a quantitative manner from birth, such a predisposition to cancer is eliminated with inexpensive medical terapy, i.e.,Reconstructing Mitochondrial Quantum Therapy (2, 3). Really, patients with lung cancer generally have a poor prognosis with a 5-year survival. Thus, preventing an illness is better than cure it, especially if it is impossible to cure it, as the malignancy.I read in the article that the crude extract from Pseudoalteromonas haloplanktis TAC125 was the most active in inhibiting cell proliferation. In addition, extensive bioassay-guided purification and mass spectrometric characterization allowed the identification of 4-hydroxybenzoic acid (4-HBA), able to activate, at the gene and protein levels, a specific cell death signaling pathway named pyroptosis. Accordingly, the treatment of A549 cells with 4-HBA induces the transcription of (amongst others) caspase-1, IL1β, and IL18 encoding genes. Notoriously, in whatever cell, both healthy and cancerous, there are endless cell pathways, harmoniously collaborating. Aiming to reprogramm the sick cell with just one molecule is how to restore the city traffic using only one traffic policeman. Finally, “because of ethical, medical, and economic limitations and constraints on the number of patients eligible for clinical trials, most of the research has to be done in experimental systems . Moreover, according to our survey, the biological mechanism of action remains unknown for 79.3% of compounds tested in vitro”. The most efficient therapy of cancer it’s Pre-Primary and Primary Prevention (1-3)

References.
1) Sergio Stagnaro and Simone Caramel. BRCA-1
and BRCA-2 mutation bedside detection and breast cancer clinical primary
prevention. Front. Genet. | doi: 10.3389/fgene.2013.00039.
http://www.frontiersin.org/…
[MEDLINE]

2) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays
a Central Role in the Primary Prevention of Mitochondrial-dependent
Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov… [MEDLINE];

3)Sergio Stagnaro and Simone Caramel (2013). The Role of Modified Mediterranean Diet and Quantum Therapy in Oncological Primary Prevention. Bentham PG., CurrentNutrition & Food Science ISSN (Print): 1573-4013; ISSN (Online): 2212-3881.
VOLUME: 9, ISSUE: 1; DOI: 10.2174/1573401311309010011; http://www.benthamscience.c…

Le epidemie di CVD/CAD, T2DM, Cancro, sono anche enormi business. Questa è la causa principale del loro continuo aumento.

Mail inevase inviate al Journal of American College of Cardiology: Unthinkable, JACC ignores CAD Inherited Real Risk.

“Nulla è così buono per una persona ignorante quanto il silenzio; e se egli fosse cosciente di questo non sarebbe un ignorante.”

Saadi

Se anche il celebre American College of Cardiology ignora il Reale Rischio Congenito di CAD, dipendente dalla Costituzione aterosclerotica, la Strage degli Innocenti è destinata a continuare . Il dato più sorprendente, corroborato dai Medici esperti in Diagnostica Psicocinetica, è la elevaya prevalenza di Cardiologi a rischi di CAD con e senza tendenza all’Infarto Miocardico. Come dire che se i Cardiologi non sanno prevenire il loro IMA, come si può pretendere che  possano prevenire quello di chi mi legge?

Di seguito potete prendere visione delle mail inviate a Membri dell’ACC  rimaste inevase.  Le pubblico perché i destinatari non meritano il mio rispetto.

——– Messaggio Inoltrato ——–

Oggetto:	Re: Unthinkable, JACC ignores CAD Inherited Real Risk.
Data:	Sat, 13 Jan 2018 08:53:30 +0100
Mittente:	Sergio Stagnaro <dottsergio@semeioticabiofisica.it>
A:	nnapoli@acc.org

 

Dear ACC  Prof. Nicole Napoli, Mary Norine Walsh,B. Hadley Wilson, Deepak L. Bhatt, Cathleen Biga,Paul N. Casale, Richard A. Chazal, Robert C. Hendel, Dipti Itchhaporia, Christopher M. Kramer,

I have sent the following mail to ACC. What do you think about? ……………………………………
——– Messaggio Inoltrato ——–

Oggetto:	Unthinkable, JACC ignores CAD Inherited Real Risk.
Data:	Thu, 12 Feb 2015 11:27:12 +0100
Mittente:	Sergio Stagnaro <dottsergio@semeioticabiofisica.it>
A:	jaccsd@acc.org, jacchf@acc.org, LRosenthal@accardiology.com, resource@acc.org, Presidente SISBQ Simone Caramel <simonecaramel@yahoo.it>

Dear JACC Editors,

in 2015 AJCC still ignores the CAD Inherited Real Risk (1-34). I cannot imagine  what accounts for the reason of such a distressing event.
And you?

_________________________________________________________________________

——– Messaggio Inoltrato ——–

Oggetto:	What accounts for the reason you, ACC, are not allowed to speak of CAD primary prevention.
Data:	Fri, 12 Jan 2018 08:29:21 +0100
Mittente:	Sergio Stagnaro <dottsergio@semeioticabiofisica.it>
A:	resource@acc.org
CC:	segreteriascientifica@sicardiologia.it, Sisbq mailing list <sisbq_medicaldoctors@yahoogroups.com>

 

Dear American College of Cardiology Colleagues,

you continue to speak abusively,  like the SIC, Società Italiana di Cardiologia, of Primary Prevention. Overlooking Inherited Real Risk of CAD and all other heart disorders, it isn’t allowed to spread among physician any  Pre-Primary,  http://www.sisbq.org/qbs-magazine.html, and  Primary Prevention:

 

CAD INHERITED REAL RISK.

REFERENCES

 

1) Sergio Stagnaro   (29 May 2008) Bedside Recognizing CAD Inherited Real Risk and silent CAD with Biophysical Semeiotics. http://www.lipidworld.com/content/7/1/19/comments

 

2) Sergio Stagnaro and Simone Caramel (2012) Quantum Biophysical Semeiotics Microcirculatory Theory of Arteriosclerosis – www.sisbq.org, Journal of Quantum Biophysical Semeiotics, first version, http://www.sisbq.org/uploads/5/6/8/7/5687930/ats_qbs__mctheory.pdf

 

3) Sergio Stagnaro, Use of multiple markers and improvement of the prediction model for cardiovascular mortality, www.nature.com, 21 May, 2008 http://network.nature.com/forums/pmgs/1587?page=1

 

4)   Stagnaro Sergio.    CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. International Atherosclerosis Society. www.athero.org, 29 April, 2009  http://www.athero.org/commentaries/comm907.asp

 

5) Sergio Stagnaro Bed-side biophysical semeiotic recognizing CAD “inherited real risk” and overt CAD, event silent. l: (18 October 2003). www.bmj.com, http://www.bmj.com/cgi/eletters/327/7420/895

 

6) Sergio Stagnaro Assessing NK cell compartment in individuals with CAD Inherited Real Risk. Immunity & Aging, (14 May 2007), http://www.immunityageing.com/content/4/1/3/comments

 

7) Sergio Stagnaro. Bedside Biophysical-Semeiotic Recognizing CAD Real Risk and silent CAD. Journal Review, http://journalreview.org/v2/articles/view/16449729.html

 

8) Sergio Stagnaro. A Clinical Biophysical-Semeiotic Contribution reliable in prompt recognizing CAD, even silent. BMC.Cardiovascular Disorders, 2005, http://www.biomedcentral.com/1471-2261/5/5/comments

 

9)   Sergio Stagnaro. Without CAD Inherited Real Risk, All Environmental Risk Factors of CAD are innocent Bystanders. Canadian Medical Association Journal. CMAJ, 14 Dec 2009,  http://www.cmaj.ca/content/181/12/E267/reply

 

10) Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology, 2007. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php

 

11) Sergio Stagnaro.  A Clinical Method far better than Blood Cell Count in CAD Primary Prevention. www.bmj.com, 2005, http://www.bmj.com/cgi/eletters/330/7493/690

 

12) Sergio Stagnaro.  Biophysical Semeiotics is really useful in order to bed-side recognizing heart ischaemic disease, even before its onset, i.e., real risk of coronary artery disease. BMC. Cardiovascular Diseases, 2004, http://www.biomedcentral.com/1471-2261/3/12/comments

 

13) Stagnaro Sergio.   Bedside Evaluation of CAD biophysical-semeiotic inherited real risk under NIR-LED treatment. EMLA Congress, Laser Helsinki August 23-24, 2008. “Photodiagnosis and photodynamic therapy”, Elsevier, Vol. 5 suppl 1 august 2008 issn 1572-1000.

 

14) Sergio Stagnaro    Biophysical-Semeiotic Diagnosing Cad “real” risk, as well as pre-clinical and clinical CAD.  www.bmj.com, (12 September 2003) http://bmj.bmjjournals.com/cgi/eletters/327/7415/591

 

15)   Sergio Stagnaro    Bedside Biophysical Semeiotic Evaluation of Acute Phase Proteins. Ann Family Med. 2008, http://www.annfammed.org/cgi/eletters/6/2/100

 

16)   Sergio Stagnaro.  EBM “and” Single Patient Based Medicine, Medical News today, 2007, http://www.medicalnewstoday.com/youropinions.php?opinionid=23466

 

17) Sergio Stagnaro. Inherited Real Risk of CAD and Cancer, www.nature.com, 2008, http://blogs.nature.com/news/thegreatbeyond/2008/01/can_shining_lights_on_your_hea_1.html

 

18) Sergio Stagnaro (2012). I Segni di Caotino* e di Gentile** nella Diagnosi di Reale Rischio Congenito di CAD e di Infarto Miocardico, ancorché iniziale o silente. Fisiopatologia e Terapia. Lectio Magistralis. III Convegno della SISBQ, 9-10 Giugno 2012, Porretta Terme (Bologna). www.sisbq.org. http://www.sisbq.org/uploads/5/6/8/7/5687930/presentazione_stagnaro_it.pdf ; English version: http://www.sisbq.org/uploads/5/6/8/7/5687930/presentazione_stagnaro_eng.pdf

 

19) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, http://www.travelfactory.it, Roma, 2009.

 

20) Simone Caramel and Sergio Stagnaro (2012).  Vascular calcification and Inherited Real Risk of lithiasis. Front. In Endocrin. 3:119. doi: 10.3389/fendo.2012.00119

http://www.frontiersin.org/Bone_Research/10.3389/fendo.2012.00119/full [MEDLINE].

 

21) Sergio Stagnaro and Simone Caramel (2013). The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., 67, 683 (June 2013) | doi:10.1038/ejcn.2013.37, http://www.nature.com/ejcn/journal/v67/n6/full/ejcn201337a.html. [MEDLINE].

 

22) Sergio Stagnaro (2013). Two Clinical Evidences Corroborating Microcirculatory Quantum-Biophysical-Semeiotic Theory of Atherosclerosis.  Lectio Magistralis, IV Congress of SISBQ, Porretta Terme (Bologna), 4-5 May, 2013 www.sisbq.org, http://www.sisbq.org/uploads/5/6/8/7/5687930/atherotheory_evidences.pdf

 

23) Sergio Stagnaro and Simone Caramel.  The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.org/Epigenomics_and_Epigenetics/10.3389/fgene.2013.00055/full [MEDLINE]

 

24) Sergio Stagnaro (2013). Two Clinical Evidences corroborating Microcirculatory QBS Theory of Atherosclerosis. Lectio Magistralis, IV Meeting of Quantum Biophysical Semeiotics International Society, May 4-5, 2013, Porretta Terme, Bologna, Auditorium, Hotel Santoli. Journal of QBS, http://www.sisbq.org/uploads/5/6/8/7/5687930/atherotheory_evidences.pdf

25) Sergio Stagnaro (2013). Abdominal Aortic Aneurism Inherited Real Risk: Patho-Physiology, Quantum-Biophysical-Semeiotic Symptomatology, Diagnosis and Therapy. www.sisbq.org. Journal of Quantum Biophysical Semeiotics. http://www.sisbq.org/uploads/5/6/8/7/5687930/aaa_irr_lectio_magistralis_2013.pdf

 

26) Sergio Stagnaro, Simone Caramel. Inherited Real Risk of Coronary Artery Disease: pathophysiology, diagnosis and primary prevention. Epidemiology and Cardiovascular Prevention. Brief Communication. 8th International Congress of Cardiology in the internet. Published: 28 October 2013. FAC Federaciòn Argentina de Cardiologia http://fac.org.ar/8cvc/llave/tl054_stagnaro/tl054_stagnaro.php   – PDF

 

27) Sergio Stagnaro. CAD Inherited Real Risk In Preventing Myocardial Infarct. http://www.sci-vox.com, 13 September, 2010.  http://www.sci-vox.com/stories/story/2010-09-13cad+inherited+real+risk+in+preventing++myocardial+infarct..html

 

28) Sergio Stagnaro. Reale Rischio Congenito di Infarto miocardio. Fondamentali Aspetti Teorici, 2014.  www.sisbq.org, http://www.sisbq.org/uploads/5/6/8/7/5687930/rrcima2014_sstagnaro.pdf

 

29) Sergio Stagnaro. Reale Rischio Congenito di Infarto Miocardio, 20014. Diagnosi e Terapia. http://www.sisbq.org/uploads/5/6/8/7/5687930/rrcima2014_sstagnaro.pdf

 

30) Pyatakovich F.A., Stagnaro S.,   Caramel S., Yakunchenko T.I., Makkonen K.F., Moryleva O.N.  Background Millimeter Radiation Influence in Cardiology on patients with metabolic and pre-metabolic  syndrome. Journal of Infrared and Millimeter Waves, , Shanghai, China http://journal.sitp.ac.cn/hwyhmb/hwyhmben/ch/reader/view_abstract.aspx?file_no=120750&flag=1

 

31) Simone Caramel (2010). Coronary Artery Disease and Inherited Real Risk of CAD. Journal of Quantum Biophysical Semeiotics. http://www.sisbq.org/uploads/5/6/8/7/5687930/cad_caramel.pdf

 

31) Sergio Stagnaro, Simone Caramel. Inherited Real Risk of Coronary Artery Disease: pathophysiology, diagnosis and primary prevention. Epidemiology and Cardiovascular Prevention. Brief Communication. 8th International Congress of Cardiology in the internet. Published: 28 October 2013. FAC Federaciòn Argentina de Cardiologia http://fac.org.ar/8cvc/llave/tl054_stagnaro/tl054_stagnaro.php   – PDF

 

32) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., http://www.nature.com/ejcn/journal/v67/n6/full/ejcn201337a.html [Medline]

34) Simone Caramel, Marco Marchionni and Sergio Stagnaro (2014). The Glycocalyx Bedside Evaluation Plays A Central Role in Diagnosing Type 2 Diabetes Mellitus and in its Primary Prevention. Treatment Strategies – Diagnosing Diabetes, Cambridge Research Centre, Volume 6 Issue 1, Pg 41-43. http://viewer.zmags.com/publication/0aafcae9#/0aafcae9/1

35) Mario Siniscalchi, Simone Caramel, Sergio Stagnaro (2016). Quando il fonendoscopio aiuta il cardiologo. Cuore e Vasi. Anno XXXVII • N. 3-4/2015, dicembre. Pg.15.

 

VERITAS FILIA TEMPORIS. Mentre ora impongono le  vaccinazioni per Legge, a Edward Jenner risposero picche!

Anche l’American College of Cardiology parla abusivamente di Prevenzione Primaria e ignora la Prevenzione Pre-Primaria

“La pazienza è la strada più difficile sulla quale rimanere, ma è il cammino più sicuro per la vittoria.” David  Weinbaum

Sono molte le cosiddette Autorità competenti che osano parlare di Prevenzione Primaria, nella totale ignoranza di quella Pre-Primaria, senza esserne autorizzate. Infatti, che prevenzione primaria osano annunciare e suggerire se non conoscono chi è positivo al Reale Rischio Congenito (RRC), dipendente dalla relativa Costituzione SBQ.  Nel nostro caso, queste Autorità USA, non conoscono il RRC di CAD, ma si sentono autorizzati a parlare di prevenzione Primaria.

Leggete la mail di oggi, inviata ai Colleaghi dell’ACC.

——– Messaggio Inoltrato ——–

Oggetto:	What accounts for the reason you, ACC, are not allowed to speak of CAD primary prevention.
Data:	Fri, 12 Jan 2018 08:29:21 +0100
Mittente:	Sergio Stagnaro <dottsergio@semeioticabiofisica.it>
A:	resource@acc.org
CC:	segreteriascientifica@sicardiologia.it, Sisbq mailing list <sisbq_medicaldoctors@yahoogroups.com>

 

Dear American College of Cardiology Colleagues,

you continue to speak abusively,  like the SIC, Società Italiana di Cardiologia, of Primary Prevention. Overlooking Inherited Real Risk of CAD and all other heart disorders, it isn’t allowed to spread among physician any  Pre-Primary,  http://www.sisbq.org/qbs-magazine.html, and  Primary Prevention:

 

CAD INHERITED REAL RISK.

 REFERENCES

 

1) Sergio Stagnaro   (29 May 2008) Bedside Recognizing CAD Inherited Real Risk and silent CAD with Biophysical Semeiotics. http://www.lipidworld.com/content/7/1/19/comments

 

2) Sergio Stagnaro and Simone Caramel (2012) Quantum Biophysical Semeiotics Microcirculatory Theory of Arteriosclerosis – www.sisbq.org, Journal of Quantum Biophysical Semeiotics, first version, http://www.sisbq.org/uploads/5/6/8/7/5687930/ats_qbs__mctheory.pdf

 

3) Sergio Stagnaro, Use of multiple markers and improvement of the prediction model for cardiovascular mortality, www.nature.com, 21 May, 2008 http://network.nature.com/forums/pmgs/1587?page=1

 

4)   Stagnaro Sergio.    CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. International Atherosclerosis Society. www.athero.org, 29 April, 2009  http://www.athero.org/commentaries/comm907.asp

 

5) Sergio Stagnaro  Bed-side biophysical semeiotic recognizing CAD “inherited real risk” and overt CAD, event silent. l: (18 October 2003). www.bmj.com, http://www.bmj.com/cgi/eletters/327/7420/895

 

6) Sergio Stagnaro Assessing NK cell compartment in individuals with CAD Inherited Real Risk. Immunity & Aging, (14 May 2007),  http://www.immunityageing.com/content/4/1/3/comments

 

7) Sergio Stagnaro.  Bedside Biophysical-Semeiotic Recognizing CAD Real Risk and silent CAD. Journal Review, http://journalreview.org/v2/articles/view/16449729.html

 

8)  Sergio Stagnaro.  A Clinical Biophysical-Semeiotic Contribution reliable in prompt recognizing CAD, even silent. BMC.Cardiovascular Disorders, 2005, http://www.biomedcentral.com/1471-2261/5/5/comments

 

9)    Sergio Stagnaro. Without CAD Inherited Real Risk, All Environmental Risk Factors of CAD are innocent Bystanders. Canadian Medical Association Journal. CMAJ, 14 Dec 2009,  http://www.cmaj.ca/content/181/12/E267/reply

 

10)  Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology, 2007. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php

 

11)  Sergio Stagnaro.  A Clinical Method far better than Blood Cell Count in CAD Primary Prevention. www.bmj.com, 2005, http://www.bmj.com/cgi/eletters/330/7493/690

 

12)  Sergio Stagnaro.    Biophysical Semeiotics is really useful in order to bed-side recognizing heart ischaemic disease, even before its onset, i.e., real risk of coronary artery disease. BMC. Cardiovascular Diseases, 2004, http://www.biomedcentral.com/1471-2261/3/12/comments

 

13) Stagnaro Sergio.   Bedside Evaluation of CAD biophysical-semeiotic inherited real risk under NIR-LED treatment. EMLA Congress, Laser Helsinki August 23-24, 2008. “Photodiagnosis and photodynamic therapy”, Elsevier, Vol. 5 suppl 1 august 2008 issn 1572-1000.

 

14) Sergio Stagnaro    Biophysical-Semeiotic Diagnosing Cad “real” risk, as well as pre-clinical and clinical CAD.  www.bmj.com, (12 September 2003) http://bmj.bmjjournals.com/cgi/eletters/327/7415/591

 

15)   Sergio Stagnaro    Bedside Biophysical Semeiotic Evaluation of Acute Phase Proteins. Ann Family Med. 2008, http://www.annfammed.org/cgi/eletters/6/2/100

 

16)    Sergio Stagnaro.    EBM “and” Single Patient Based Medicine, Medical News today, 2007, http://www.medicalnewstoday.com/youropinions.php?opinionid=23466

 

17) Sergio Stagnaro. Inherited Real Risk of CAD and Cancer, www.nature.com, 2008, http://blogs.nature.com/news/thegreatbeyond/2008/01/can_shining_lights_on_your_hea_1.html

 

18) Sergio Stagnaro (2012).  I Segni di Caotino* e di Gentile** nella Diagnosi di Reale Rischio Congenito di CAD e di Infarto Miocardico, ancorché iniziale o silente. Fisiopatologia e Terapia. Lectio Magistralis. III Convegno della SISBQ, 9-10 Giugno 2012, Porretta Terme (Bologna).  www.sisbq.org. http://www.sisbq.org/uploads/5/6/8/7/5687930/presentazione_stagnaro_it.pdf ; English version: http://www.sisbq.org/uploads/5/6/8/7/5687930/presentazione_stagnaro_eng.pdf

 

19) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, http://www.travelfactory.it, Roma, 2009.

 

20) Simone Caramel and Sergio Stagnaro (2012).   Vascular calcification and Inherited Real Risk of lithiasis. Front. In Endocrin.  3:119. doi: 10.3389/fendo.2012.00119

http://www.frontiersin.org/Bone_Research/10.3389/fendo.2012.00119/full  [MEDLINE].

 

21) Sergio Stagnaro and Simone Caramel (2013). The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., 67, 683 (June 2013) | doi:10.1038/ejcn.2013.37, http://www.nature.com/ejcn/journal/v67/n6/full/ejcn201337a.html. [MEDLINE].

 

22) Sergio Stagnaro (2013). Two Clinical Evidences Corroborating Microcirculatory Quantum-Biophysical-Semeiotic Theory of Atherosclerosis.  Lectio Magistralis, IV Congress of SISBQ, Porretta Terme (Bologna),  4-5 May, 2013 www.sisbq.org,  http://www.sisbq.org/uploads/5/6/8/7/5687930/atherotheory_evidences.pdf

 

23) Sergio Stagnaro and Simone Caramel.  The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.org/Epigenomics_and_Epigenetics/10.3389/fgene.2013.00055/full  [MEDLINE]

 

24) Sergio Stagnaro (2013).   Two Clinical Evidences corroborating Microcirculatory QBS Theory of Atherosclerosis. Lectio Magistralis, IV Meeting of Quantum Biophysical Semeiotics International Society, May 4-5, 2013, Porretta Terme, Bologna, Auditorium, Hotel Santoli. Journal of QBS, http://www.sisbq.org/uploads/5/6/8/7/5687930/atherotheory_evidences.pdf

25) Sergio Stagnaro (2013).   Abdominal Aortic Aneurism Inherited Real Risk: Patho-Physiology, Quantum-Biophysical-Semeiotic Symptomatology, Diagnosis and Therapy. www.sisbq.org. Journal of Quantum Biophysical Semeiotics. http://www.sisbq.org/uploads/5/6/8/7/5687930/aaa_irr_lectio_magistralis_2013.pdf

 

26) Sergio Stagnaro, Simone Caramel. Inherited Real Risk of Coronary Artery Disease: pathophysiology, diagnosis and primary prevention. Epidemiology and Cardiovascular Prevention. Brief Communication. 8th International Congress of Cardiology in the internet. Published: 28 October 2013. FAC Federaciòn Argentina de Cardiologia http://fac.org.ar/8cvc/llave/tl054_stagnaro/tl054_stagnaro.php   – PDF

 

27)  Sergio Stagnaro. CAD Inherited Real Risk In Preventing Myocardial Infarct. http://www.sci-vox.com, 13 September, 2010.  http://www.sci-vox.com/stories/story/2010-09-13cad+inherited+real+risk+in+preventing++myocardial+infarct..html

 

28) Sergio Stagnaro. Reale Rischio Congenito di Infarto miocardio. Fondamentali Aspetti Teorici, 2014.  www.sisbq.org, http://www.sisbq.org/uploads/5/6/8/7/5687930/rrcima2014_sstagnaro.pdf

 

29) Sergio Stagnaro. Reale Rischio Congenito di Infarto Miocardio, 20014. Diagnosi e Terapia. http://www.sisbq.org/uploads/5/6/8/7/5687930/rrcima2014_sstagnaro.pdf

 

30) Pyatakovich F.A., Stagnaro S.,   Caramel S., Yakunchenko T.I., Makkonen K.F., Moryleva O.N.  Background Millimeter Radiation Influence in Cardiology on patients with metabolic and pre-metabolic  syndrome. Journal of Infrared and Millimeter Waves, , Shanghai, China http://journal.sitp.ac.cn/hwyhmb/hwyhmben/ch/reader/view_abstract.aspx?file_no=120750&flag=1

 

31)  Simone Caramel (2010). Coronary Artery Disease and Inherited Real Risk of  CAD.  Journal of Quantum Biophysical Semeiotics. http://www.sisbq.org/uploads/5/6/8/7/5687930/cad_caramel.pdf

 

31) Sergio Stagnaro, Simone Caramel. Inherited Real Risk of Coronary Artery Disease: pathophysiology, diagnosis and primary prevention. Epidemiology and Cardiovascular Prevention. Brief Communication. 8th International Congress of Cardiology in the internet. Published: 28 October 2013. FAC Federaciòn Argentina de Cardiologia http://fac.org.ar/8cvc/llave/tl054_stagnaro/tl054_stagnaro.php   – PDF

 

32) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., http://www.nature.com/ejcn/journal/v67/n6/full/ejcn201337a.html [Medline]

34) Simone Caramel, Marco Marchionni  and Sergio Stagnaro (2014). The Glycocalyx Bedside Evaluation Plays A Central  Role in Diagnosing Type 2 Diabetes Mellitus and in its Primary Prevention. Treatment Strategies – Diagnosing Diabetes, Cambridge Research Centre, Volume 6 Issue 1, Pg 41-43. http://viewer.zmags.com/publication/0aafcae9#/0aafcae9/1

35) Mario Siniscalchi, Simone Caramel, Sergio Stagnaro (2016). Quando il fonendoscopio aiuta il cardiologo. Cuore e Vasi. Anno XXXVII • N. 3-4/2015, dicembre. Pg.15.

 

Can I wait for your answer?

Sincerely

Dr Sergio Stagnaro

——– Messaggio Inoltrato ——–

Oggetto:	Automatic reply: What accounts for the reason you, ACC, are not allowed to speak of CAD primary prevention.
Data:	Fri, 12 Jan 2018 07:29:33 +0000
Mittente:	Resource <resource@acc.org>
A:	Sergio Stagnaro <dottsergio@semeioticabiofisica.it>

 

Thank you for contacting the American College of Cardiology. The College is closed and will reopen at 9:00 am (Eastern) on Friday, January 12, 2018.

Possibile che anche gli Editori di Nature ignorino il Reale Rischio Congenito della Malattia di Alzheimer e il Sensore Cerebellare della Arteriosclerosi cerebrale?

——– Messaggio Inoltrato ——–

Oggetto:	Ovelooking Cerebellum sensor of senile dementia and AD Inherited Real Risk the Neurology is defeat, not these diseases.
Data:	Thu, 11 Jan 2018 16:58:05 +0100
Mittente:	Sergio Stagnaro <dottsergio@semeioticabiofisica.it>
A:	naturereviews@nature.com
CC:	segreteria ministero sanità <segreteriaministro@sanita.it>, SISBQ mailing list <sisbq_medicaldoctors@yahoogroups.com>, Walter Ricciardi ISS <walter.ricciardi@unicatt.it>, valeria.fedeli@senato.it, glmancardi@neurologia.unige.it, gioacchino.tedeschi@unicampania.it, roberto.eleopra@istituto-besta.it, l.provinciali@univpm.it

 

Dear NATURE Editors,

C/C to all,

at Link https://www.nature.com/articles/d41586-018-00105-6?WT.ec_id=NATURE-20180111&spMailingID=55747347&spUserID=ODc3MzA3NzY3MgS2&spJobID=1321808074&spReportId=MTMyMTgwODA3NAS2,   below the title

SEVEN DAYS

10 January 2018  Typhoid vaccine, dementia research and discrimination in science The week in science: 5–11 January 2018, distressingly I have read the following phrases: “Dementia pull-out The multinational drug firm Pfizer will abandon research on dementia treatments, joining a stream of major pharmaceutical companies that have fled the high-risk research field in the past decade. On 6 January, the company said that it expects to shed 300 US jobs from its neuroscience discovery and early stage drug-development programmes in Andover and Cambridge, both in Massachusetts, and in Groton, Connecticut. In 2012, Pfizer stopped a clinical trial of an antibody therapy for Alzheimer’s disease because it demonstrated no clinical benefit. No therapies for Alzheimer’s are yet available.”

I can not believe, but it’s true unfortunately, that even the Nature Editors, as all italian competent Autorities, ignore the Inherited Real Risk of Alzheimer’s Disease (1-4) as well as  that the cerebellum is a sensor of the future senile Dementia (5).  On these two realities, two facts,  is founded  my overlooked fight  against the AD and  the Brain ATS with or without  senile Dementia, a fight no-politically correct, I must unfortunately recognize.   Interestingly, as all other Inherited Real Risks, i.e. of CVD/CAD, T2DM, Osteoporosis, Cancer, a.s.o.,  these can be bedside diagnosed from birth with a common stethoscope and removed by Reconstructing Mitochondrial Quantum Therapy (6). Such a vitual operation, till now ignored all around the world,  I have called Pre-Primary and Primary Prevention.

1) Stagnaro Sergio. Alzheimer’s Disease Byophysical Semeiotics supports the pathophysiology of Koudinov’s theory.11 January 2002. Clin. Med. & Health Research http://clinmed.netprints.org/cgi/eletters/2001100005v1#9

2) Simone Caramel and Sergio Stagnaro. Clinical QBS Diagnosis and Primary Prevention of Brain Disorder ‘Inherited Real Risk’ and Alzheimer Disease. Journal of Quantum Biophysical Semeiotics. 5 August, 2011. http://www.sisbq.org/uploads/5/6/8/7/5687930/alzheimer_primaryprevention.pdf

3) Marco Marchionni, Simone Caramel, Sergio Stagnaro. Inherited Real Risk of Alzheimer’s Disease: bedside diagnosis and primary prevention.Frontiers in Neuroscience, in http://www.frontiersin.org/Aging_Neuroscience/10.3389/fnagi.2013.00013/full

4) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease  Primary Prevention. Letter to the Editor, The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/article/10.1007/s12603-013-0435-7  [Medline]

5) Sergio Stagnaro. Il Cervelletto è un Sensore della Predisposizione all’Aterosclerosi Cerebrale. La Manovra di De Lisi.  www.sisbq.org, http://www.sisbq.org/uploads/5/6/8/7/5687930/lisi_cervelletto_atscerebrale.pdf

6) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov/pubmed/25743850  [MEDLINE]

I can hope to receive a reply from the recipients of this email?

Note. For intellectual honesty, I inform you that this email is still on line in LA VOCE di SS www.sergiostagnaro.wordpress.com:  it is a moral duty towards present and future diseased people.

Sincerely

Dr Sergio Stagnaro
Sergio Stagnaro MD

Via Erasmo Piaggio 23/8,

16039 Riva Trigoso (Genoa) Italy

Phone 0390-0185-42315

Founder of Quantum Biophysical Semeiotics,

Honorary President of International Society of

Quantum Biophysical Semeiotics (SISBQ)

www.semeioticabiofisica.it

www.sisbq.org

www.sergiostagnaro.wordpress.com

Moya Moya Disease Patho-Physiology, according to Quantum Biophysical Semeiotic. The central Role of Mitochondrion Heritable Impairment (CAEMH) in Angiogenesis.

The aim of this article is to demonstrate the existence of Moya Moya Disease Inherited Real Risk, present in all mothers of patients suffering from Moya Moya Disease (MMD). The disease is dependent on Congenital Acidosis Enzyme-Metabolic Histagniopathy, a mitochondrial disease transmitted from the mother, conditio sine qua non of the most serious and deadly disorders.

At present, the best therapy of MMD is its Pre-Primary Prevention with Reconstructing Mitochondrial Quantum Therapy.

Moya Moya disease is an uncommon cerebrovascular condition characterized by the progressive stenosis of bilateral, less frequent unilateral, internal carotid arteries with compensatory formation of an abnormal network of perforating blood vessels providing collateral circulation (1- 7).

The etiology and pathogenesis of Moya Moaya Disease disease (MMD) is till now unclear while its diagnosis only recently has became clinical, quick and easy (7).

In following I suggest a new patho-physiological theory, based on the miochondrion heritable impairment, I have discovered 37 years ago, termed Congenital Acidosic Enzyme-Metabolic Histangiopathy (CAE-MH),underlying the cause of vascular anomalies, chacteristic of MMD (7-16).

Because they ignore Quantum Biophysical Semeiotic Inherited Real Risk of MMD, some Authors state that familial Moya Moya disease has been noted in as many as 15% of patients, indicating an autosomal dominant inheritance pattern with incomplete penetrance. Genetic analyses in familial MMD and genome-wide association studies represent promising strategies for elucidating the pathophysiology of this condition (6).

In this paper, genetic factor, i.e., MMD Inherited Real Risk, analized from Quantum Biophysical Semeiotic view-point, is outlined. This research directions promise not only to offer new insights into the origin of MMD, but to enhance our understanding of new vessel formation in the CNS, aiming to provide Physicians a new, efficient Pre-Pimary and Primary Prevention, as in all other Inherited Real Risk (8-12).

Progressive bilateral or unilateral stenosis of the internal carotid artery with frequent involvement of the proximal anterior and middle cerebral arteries is characteristic of Moya Moya disease. Histopathological studies of affected internal carotid artery segments in MMD demonstrate eccentric fibrocellular thickening of the intima, proliferated SMCs, prominently tortuous and often duplicated internal elastic lamina, with no inflammatory or atheromatous involvement (6).

Te above-mentioned arterial vessel alteration, causing Microcirculatory Activation, type I, associated, of microcirculatory units of frontal-parietal and temporal regions, really brings about also Low Grade Chronic Inflammation, detected by the refined, reliable Quantum Biophysical Semeiotic Method (7, 13).

Vessel occlusion results from excessive accumulation of SMCs and thrombosis within the lumen. It is hypothesized that in the setting of arterial stenosis or occlusion, hypoxic regions of the brain induce collateralization through the formation of dilated and tortuous perforating arteries. Histopathologically, the Moya Moya collateral vessels display thinned media with fibrin deposition in the vessel walls, fragmented elastic laminae, and microaneurysm formation (6). This native revascularization strategy is orchestrated by the expression of various growth factors involved in angiogenic signaling cascades, including HIF-1, VEGF, bFGF, transforming growth factor–β₁, hepatocyte growth factor, and MMPs (6).

Taken together these studies indicate the existence of a proangiogenic intracranial milieu in patients with MMD, as the following experimental evidence, referred in my previous article, suggets (7).

In health, digital pressure of mean intensity (700 dyne/cm.²), applied on large artery (e.g., brachial artery) brings about simultaneously Microcirculatory Activation, type I, associated, in the distal, peripheral microcirculatory-tissue units, playing a central role in bedside diagnosis.

As a matter of facts, Moya Moya disease bedside diagnosis is based on such a microcirculatory activation, brought about by carotid vessels and Willi’s circle heritable stenosis.

Future studies will also aim to develop genetic and serum biomarkers that corroborate my clinical theory, created with the data collected with the Psychokinetic Diagnostic (14, 15), demonstrating the hub role played by Congenital Acidosic Enzyme Metabolic Histangiopatie (16).

Really, Moya Moya is a neurological disease sometimes difficult to differentiate, in its early stage, from mitochondrial disorders in children when non-traumatic ischemic stroke is considered (17).

Interestingly, it is well known the relation between mitochonrial impairment and angiogenesis, I have demonstrated, for instance, as regards the Campbell De Morgan spots, skin typical sign of CAEMH (18).

Angiogenesis is a dynamic and energy-consuming process, requiring endothelial cells to switch from a quiescent state to a migratory and proliferative phenotype in order to support the formation of new blood vessels. Although proximal to blood, endothelial cells are utilize anaerobic glycolysis as an energy source to the detriment of mitochondrial oxidative phosphorylation. Notoriously there is a small amount of mitochondria in endothelial cells . In this context, endothelial mitochondria have emerged as signaling hubs that modulate a wide range of endothelial functions, including angiogenesis, by coordinating reactive oxygen species and calcium signaling, metabolism and apoptosis (19). As a consequence, Authors focus on recent findings identifying mitochondrial targeting compounds that exhibit pro-angiogenic or anti-angiogenic properties, and could therefore be of clinical importance for the treatment of vascular pathologies (19).

Interesting for my hypothesis is a research in which the decreased expression of vascular endothelial growth factor (VEGF) in the renal tubules is thought to cause progressive loss of the renal microvasculature with age (20).

Mitochondrial dysfunction may be a principal phenomenon underlying the process of aging. The relation between VEGF expression and mitochondrial dysfunction in aging is not fully understood, because CAEMH is still largely unknown. If mitochondrial dysfunction blocks VEGF expression than it contributes to impaired angiogenesis in the aging kidney (20).

VEGF are able to modify endothelial cell phenotype. Under physiological or non-pathological conditions, endothelial cells remain quiescent under a balance of pro- and anti-angiogenic factors. When pro-angiogenic factors dominate, endothelial cells quickly switch to angiogenic phenotypes that are categorized as either migratory tip cells or proliferating stalk cells (21). Although research on angiogenesis has revealed key mechanisms that regulate tissue vascularization, therapeutic success has been limited owing to insufficient efficacy, refractoriness and tumor resistance (22).

Emerging concepts suggest that, in addition to growth factors, vascular metabolism also regulates angiogenesis and is a viable target for manipulating the microvasculature. Recent studies show that endothelial cells rely on anaerobic glycolysis for ATP production, and that the key glycolytic regulator 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) regulates angiogenesis by controlling the balance of tip versus stalk cells (22).

As endothelial cells acquire a tip cell phenotype, e.g., due to local acidosis as it appears in localized area of individual with intense CAEMH, they increase glycolytic production of ATP for sprouting. Authors report a detailed description of a family affected by a hereditary multisystem disorder associated with moyamoya syndrome (23).

In my opinion, the mother transmit via mitochondria the Inherited Real Risk of MMD, rather than the disease itself.

The QBS symptomatology of MMD Inherited Real Risk, bedside diagnosis is based on, consists of:

1. reduced Latency Time of Ocular-Gastric Aspecific Reflex: 4-5 sec. (NN = 8 sec.). Its intensity is significantly higher than the normal one: 4 cm. versus 2 cm.;
2. reduced Latency Time of parietal-, temporal-, frontal- Brain area-Gastric Aspecific Reflex: 5-6 sec. (NN = 8 sec.). Interestingly, the intensity of the reflex is also higher than the normal one: 4 cm. versus 2 cm.. In occipital and cerebellar areas microcirculation is apparently physiological; Latency Time of brain- gastric aspecific reflex is normal, i.e., 8 sec, but the Duration is 4 sec. (NN > 3 sec.-4 sec <9
3. in all above-mentioned brain areas there is Microcirculatory Activation, type I, associated (7), whose intensity increases with the passing of the years from birth;
4. in the above-mentioned cerebral convolutions there is Low Grade Chronic Inflammation (LGCI), as in all other cases (24). The evaluation of LGCI allows doctor to recognize the stage of disease, paralleling the seriousness of underlying disorder.

In overt MMD all signs are worsened, in relation to the stage of disease. Women, apparently healthy, but involved by MMD Inherited Real Risk, before the beginning of a pregnancy, must initiate the Reconstructing Mitochondrial Quantum Therapy, under accurate therapeutic monitoring to personalize the treatment (25).

References.

1)      Jin Pyeong Jeon, MD, Taeho Yun, MS, Xing Jin, et al. H-NMR-Based Metabolomic Analysis of Cerebrospinal Fluid From Adult Bilateral Moyamoya Disease. Comparison With Unilateral Moyamoya Disease and Atherosclerotic Stenosis. Medicine (Baltimore). 2015 May; 94(17): e629. [Medline]

2)      Scott RM, Smith ER. Moyamoya disease and moyamoya syndrome. N Engl J Med 2009; 360:1226–1237. [Medline]

3)      Houkin K, Ito M, Sugiyama T, et al. Review of past research and current concepts on the etiology of moyamoya disease. Neuro Med Chir (Tokyo) 2012; 52:267–277. [Medline]

4)      Kim JE, Jeon JS. An update on the diagnosis and treatment of adult moyamoya disease taking into consideration controversial issues. Neurol Res 2014; 36:407–416. [Medline]

5)      Jin Pyeong Jeon, Jeong Eun Kim. Pathophysiology of Moyamoya Disease. Acute Ischemic Stroke pp 27-34, 2017. https://link.springer.com/chapter/10.1007/978-981-10-0965-5_2

6) Achal S. Achrol, B.S., Raphael Guzman, M.D., Marco Lee, M.D., Ph.D., et al. Moyamoya Disease Pathophysiology and genetic factors in moyamoya disease. Neurosurgical Focus. April 2009 / Vol. 26 / No. 4 / Page E4

7) Stagnaro Sergio . Quantum Biophysical Semeiotic of Moya Moya Disease. Clinical Diagnosis of  its Inherited Real Risk and Pre-Primary and Primary Prevention. http://www.sisbq.org/uploads/5/6/8/7/5687930/moyamoya.pdf e https://dabpensiero.wordpress.com/2017/12/30/quantum-biophysical-semeiotic-of-moya-moya-disease-clinical-diagnosis-of-its-inherited-real-risk-and-pre-primary-and-primary-prevention/

8) Sergio Stagnaro and Simone Caramel.  BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention.  Front. Genet. | doi: 10.3389/fgene.2013.00039.  http://www.frontiersin.org/Cancer_Genetics/10.3389/fgene.2013.00039/full [MEDLINE]

9) Sergio Stagnaro and Simone Caramel.  The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.org/Epigenomics_and_Epigenetics/10.3389/fgene.2013.00055/full  [MEDLINE]

10) Simone Caramel and Sergio Stagnaro (2012).   Vascular calcification and Inherited Real Risk of lithiasis. Front. In Encocrin.  3:119. doi: 10.3389/fendo.2012.00119 http://www.frontiersin.org/Bone_Research/10.3389/fendo.2012.00119/full [MEDLINE]

11) Sergio Stagnaro and Simone Caramel (2012). “The Role of Mediterranean Diet, CoQ10 and Conjugated-Melatonin in Osteoporosis Primary Prevention and Therapy”  “Current Nutrition & Food Science” Vol. 8, No.1, 2012.

12) Sergio Stagnaro and Simone Caramel (2012). Quantum Therapy: A New Way in Osteoporosis Primary Prevention and Treatment. Journal of Pharmacy and Nutrition Sciences, (27 June 2012) | doi:10.1038/ejcn.2012.76, http://www.nature.com/doifinder/10.1038/ejcn.2012.76. PMID:22739250  [MEDLINE]

13) Sergio Stagnaro – Marina Neri Stagnaro. Microangiologia Clinica. A cura di Simone Caramel. e-book, www.sisbq.org, http://www.sisbq.org/uploads/5/6/8/7/5687930/microangiologiaclinicasbq2016.pdf

14) Sergio Stagnaro.  Semeiotica Biofisica Quantistica. Diagnostica Psicocinetica. E-book in rete nel sito  www.sisbq.org; http://www.sisbq.org/uploads/5/6/8/7/5687930/dp_libro.pdf

15) Sergio Stagnaro.  PSYCHOKINETIC DIAGNOSTICS, QUANTUM-BIOPHYSICAL-SEMEIOTICS EVOLUTION. Journal of Quantum Biophysical Semeiotic  Society. http://www.sisbq.org/uploads/5/6/8/7/5687930/psychokineticdiagnostics_qbsevolution.pdf

16) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. Gazz Med. It. – Asch. Sci, Med. 144, 423

17) Hsu ML, Chen CJ, Juan CJ, Yuh YS, Cheng SN, Chen SJ. Moyamoya disease initially mimicking MELAS syndrome in a 14-month-old child. Acta Paediatr Taiwan. 2004 Mar-Apr;45(2):104-7.

18) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004.   http://www.travelfactory.it/semeiotica_biofisica.htm

19) Marcu R, Zheng Y, Hawkins BJ. Mitochondria and Angiogenesis. Adv Exp Med Biol.  2017;982:371-406. doi: 10.1007/978-3-319-55330-6_21. https://link.springer.com/chapter/10.1007%2F978-3-319-55330-6_21

20) Fujimoto S, Horike H, Ozeki M, Nagasu H, Tomita N, Sasaki T, Kashihara N. Mitochondrial damage-induced impairment of angiogenesis in the aging rat kidney. Lab Invest. 2011 Feb;91(2):190-202. doi: 10.1038/labinvest.2010.175. Epub 2010 Oct 4.

21) Adams, R. H. and Alitalo, K. (2007). Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 8, 464–478. doi:10.1038/nrm2183

22) D. Hervé, P. Touraine, A. Verloes, S. Miskinyte, V. Krivosic. Et al. A hereditary moyamoya syndrome with multisystemic manifestations. Neurology, July 20, 2010; 75 (3) http://n.neurology.org/content/75/3/259

23) Peter Stapor, Xingwu Wang, Jermaine Goveia, Stijn Moens, Peter Carmeliet.

Commentary. Angiogenesis revisited – role and therapeutic potential of targeting endothelial metabolism. J Cell Sci 2014 127: 4331-4341; doi: 10.1242/jcs.153908

http://jcs.biologists.org/content/127/20/4331

24) Sergio Stagnaro.  Ruolo del Muscolo – Scheletrico nella Diagnosi Clinica. Il Riflesso della Low Grade Chronic Inflammation e la Manovra di Bardi.  http://www.sisbq.org/uploads/5/6/8/7/5687930/muscoloscheletricobardi2016.pdf

25) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov/pubmed/25743850[MEDLINE]