“Peccare di silenzio, quando bisognerebbe protestare, fa di un uomo un codardo”. ELLA WHEELER WILCOX
Dear Prof David Preiss
Dear Diabetologia Editors,
C/C Soc. Ital Diabetologia,
segreteria Ministero Sanità,
sisbq mailing list,
I have just read the paramount, arcadian, paper, Diabetologia March 2017, Volume 60, Issue 3, pp 381–389 PCSK9 inhibition: the dawn of a new age in cholesterol lowering, David Preiss and Marion Mafham. Overlooking no-politically correct Diabetic Constitution-Dependent, Inherited Real Risk of T2DM the present growing epidemic will surely continue:
1)Sergio Stagnaro and Simone Caramel (2013). Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology. 26 February 2013 | http://dx.doi.org/10.3389/fendo.2013.00017; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581808/[MEDLINE]
2)Simone Caramel, Marco Marchionni and Sergio Stagnaro. The Glycocalyx Bedside Evaluation Plays A Central Role in Diagnosing Type 2 Diabetes Mellitus and in its Primary Prevention. Treatment Strategies – Diagnosing Diabetes, Cambridge Research Centre, Volume 6 Issue 1, Pg 41-43. http://viewer.zmags.com/publication/0aafcae9#/0aafcae9/1
3)Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [MEDLINE]
5)Sergio Stagnaro. My way in the War against Five Stages of type 2 Diabetes Mellitus. http://doc2doc.bmj.com/forums/open-clinical_diabetes_way-war-against-five-stages-of-type-2-diabetes-mellitus, 2013.
6) Sergio Stagnaro. La Taileverina, prodotta nella Coda del Pancreas, svolge un ruolo importante nella diagnosi clinica dei Cinque Stadi diabetici. https://sergiostagnaro.wordpress.com/2017/02/02/la-taileverina-prodotta-nella-coda-del-pancreas-svolge-un-ruolo-importante-nella-diagnosi-clinica-dei-cinque-stadi-diabetici/
7) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. https://www.researchgate.net/publication/273147071_Morinda_citrifolia_Plays_a_Central_Role_in_the_Primary_Prevention_of_Mitochondrial-dependent_Degenerative_Disorders
http://www.ncbi.nlm.nih.gov/pubmed/25743850 [MEDLINE]
8) Sergio Stagnaro (2017). Diabete ed epatopatia: nuovi approcci in diagnosi clinica secondo la Semeiotica Biofisica Quantistica. Taileverina. Scienza&Conoscenza
http://www.scienzaeconoscenza.it/blog/medicina-non_convenzionale/diabete-ed-epatopatia-nuovi-approcci-in-diagnosi-clinica
9) Sergio Stagnaro (2017). La Taileverina, prodotta nella Coda del Pancreas, svolge un ruolo importante nella diagnosi clinica dei Cinque Stadi diabetici. https://sergiostagnaro.wordpress.com/2017/02/02/la-taileverina-prodotta-nella-coda-del-pancreas-svolge-un-ruolo-importante-nella-diagnosi-clinica-dei-cinque-stadi-diabetici/
Let me put the question: “In your clinical experience did you not have observed subjects with high level of LDL but not involved by T2DM and/or CAD ?”.
In following, my clinical explanation:
ATS Constitution-Dependent, CAD INHERITED REAL RISK.
REFERENCES
1) Sergio Stagnaro (29 May 2008) Bedside Recognizing CAD Inherited Real Risk and silent CAD with Biophysical Semeiotics. http://www.lipidworld.com/content/7/1/19/comments
2) Sergio Stagnaro and Simone Caramel (2012) Quantum Biophysical Semeiotics Microcirculatory Theory of Arteriosclerosis – www.sisbq.org, Journal of Quantum Biophysical Semeiotics, first version, http://www.sisbq.org/uploads/5/6/8/7/5687930/ats_qbs__mctheory.pdf
3) Sergio Stagnaro, Use of multiple markers and improvement of the prediction model for cardiovascular mortality, www.nature.com, 21 May, 2008 http://network.nature.com/forums/pmgs/1587?page=1
4) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. International Atherosclerosis Society. www.athero.org, 29 April, 2009 http://www.athero.org/commentaries/comm907.asp
5) Sergio Stagnaro Bed-side biophysical semeiotic recognizing CAD “inherited real risk” and overt CAD, event silent. l: (18 October 2003). www.bmj.com, http://www.bmj.com/cgi/eletters/327/7420/895
6) Sergio Stagnaro Assessing NK cell compartment in individuals with CAD Inherited Real Risk. Immunity & Aging, (14 May 2007), http://www.immunityageing.com/content/4/1/3/comments
7) Sergio Stagnaro. Bedside Biophysical-Semeiotic Recognizing CAD Real Risk and silent CAD. Journal Review, http://journalreview.org/v2/articles/view/16449729.html
8) Sergio Stagnaro. A Clinical Biophysical-Semeiotic Contribution reliable in prompt recognizing CAD, even silent. BMC.Cardiovascular Disorders, 2005, http://www.biomedcentral.com/1471-2261/5/5/comments
9) Sergio Stagnaro. Without CAD Inherited Real Risk, All Environmental Risk Factors of CAD are innocent Bystanders. Canadian Medical Association Journal. CMAJ, 14 Dec 2009, http://www.cmaj.ca/content/181/12/E267/reply
10) Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology, 2007. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php
11) Sergio Stagnaro. A Clinical Method far better than Blood Cell Count in CAD Primary Prevention. www.bmj.com, 2005, http://www.bmj.com/cgi/eletters/330/7493/690
12) New bedside way in Reducing mortality in diabetic men and women.
Ann Int Med.2007. http://www.annals.org/cgi/eletters/147/3/149
12) Sergio Stagnaro. Biophysical Semeiotics is really useful in order to bed-side recognizing heart ischaemic disease, even before its onset, i.e., real risk of coronary artery disease. BMC. Cardiovascular Diseases, 2004, http://www.biomedcentral.com/1471-2261/3/12/comments
13) Stagnaro Sergio. Bedside Evaluation of CAD biophysical-semeiotic inherited real risk under NIR-LED treatment. EMLA Congress, Laser Helsinki August 23-24, 2008. “Photodiagnosis and photodynamic therapy”, Elsevier, Vol. 5 suppl 1 august 2008 issn 1572-1000.
14) Sergio Stagnaro Biophysical-Semeiotic Diagnosing Cad “real” risk, as well as pre-clinical and clinical CAD. www.bmj.com, (12 September 2003) http://bmj.bmjjournals.com/cgi/eletters/327/7415/591
15) Sergio Stagnaro Bedside Biophysical Semeiotic Evaluation of Acute Phase Proteins. Ann Family Med. 2008, http://www.annfammed.org/cgi/eletters/6/2/100
16) Sergio Stagnaro. EBM “and” Single Patient Based Medicine, Medical News today, 2007, http://www.medicalnewstoday.com/youropinions.php?opinionid=23466
17) Sergio Stagnaro. Inherited Real Risk of CAD and Cancer, www.nature.com, 2008, http://blogs.nature.com/news/thegreatbeyond/2008/01/can_shining_lights_on_your_hea_1.html
18) Sergio Stagnaro (2012). I Segni di Caotino* e di Gentile** nella Diagnosi di Reale Rischio Congenito di CAD e di Infarto Miocardico, ancorché iniziale o silente. Fisiopatologia e Terapia. Lectio Magistralis. III Convegno della SISBQ, 9-10 Giugno 2012, Porretta Terme (Bologna). http://www.sisbq.org. http://www.sisbq.org/uploads/5/6/8/7/5687930/presentazione_stagnaro_it.pdf ; English version: http://www.sisbq.org/uploads/5/6/8/7/5687930/presentazione_stagnaro_eng.pdf
19) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, 2009.
20) Simone Caramel and Sergio Stagnaro (2012). Vascular calcification and Inherited Real Risk of lithiasis. Front. In Endocrin. 3:119. doi: 10.3389/fendo.2012.00119
http://www.frontiersin.org/Bone_Research/10.3389/fendo.2012.00119/full [MEDLINE].
21) Sergio Stagnaro and Simone Caramel (2013). The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., 67, 683 (June 2013) | doi:10.1038/ejcn.2013.37, http://www.nature.com/ejcn/journal/v67/n6/full/ejcn201337a.html. [MEDLINE].
22) Sergio Stagnaro (2013). Two Clinical Evidences Corroborating Microcirculatory Quantum-Biophysical-Semeiotic Theory of Atherosclerosis. Lectio Magistralis, IV Congress of SISBQ, Porretta Terme (Bologna), 4-5 May, 2013 www.sisbq.org, http://www.sisbq.org/uploads/5/6/8/7/5687930/atherotheory_evidences.pdf
23) Sergio Stagnaro and Simone Caramel. The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.org/Epigenomics_and_Epigenetics/10.3389/fgene.2013.00055/full [MEDLINE]
24) Sergio Stagnaro (2013). Two Clinical Evidences corroborating Microcirculatory QBS Theory of Atherosclerosis. Lectio Magistralis, IV Meeting of Quantum Biophysical Semeiotics International Society, May 4-5, 2013, Porretta Terme, Bologna, Auditorium, Hotel Santoli. Journal of QBS, http://www.sisbq.org/uploads/5/6/8/7/5687930/atherotheory_evidences.pdf
25) Sergio Stagnaro (2013). Abdominal Aortic Aneurism Inherited Real Risk: Patho-Physiology, Quantum-Biophysical-Semeiotic Symptomatology, Diagnosis and Therapy. www.sisbq.org. Journal of Quantum Biophysical Semeiotics. http://www.sisbq.org/uploads/5/6/8/7/5687930/aaa_irr_lectio_magistralis_2013.pdf
26) Sergio Stagnaro, Simone Caramel. Inherited Real Risk of Coronary Artery Disease: pathophysiology, diagnosis and primary prevention. Epidemiology and Cardiovascular Prevention. Brief Communication. 8th International Congress of Cardiology in the internet. Published: 28 October 2013. FAC Federaciòn Argentina de Cardiologia http://fac.org.ar/8cvc/llave/tl054_stagnaro/tl054_stagnaro.php – PDF
27) Sergio Stagnaro. CAD Inherited Real Risk In Preventing Myocardial Infarct. http://www.sci-vox.com, 13 September, 2010. http://www.sci-vox.com/stories/story/2010-09-13cad+inherited+real+risk+in+preventing++myocardial+infarct..html
28) Sergio Stagnaro. Reale Rischio Congenito di Infarto miocardio. Fondamentali Aspetti Teorici, 2014. www.sisbq.org, http://www.sisbq.org/uploads/5/6/8/7/5687930/rrcima2014_sstagnaro.pdf
29) Sergio Stagnaro. Reale Rischio Congenito di Infarto Miocardio, 20014. Diagnosi e Terapia. http://www.sisbq.org/uploads/5/6/8/7/5687930/rrcima2014_sstagnaro.pdf
30) Pyatakovich F.A., Stagnaro S., Caramel S., Yakunchenko T.I., Makkonen K.F., Moryleva O.N. Background Millimeter Radiation Influence in Cardiology on patients with metabolic and pre-metabolic syndrome. Journal of Infrared and Millimeter Waves, , Shanghai, China http://journal.sitp.ac.cn/hwyhmb/hwyhmben/ch/reader/view_abstract.aspx?file_no=120750&flag=1
31) Simone Caramel (2010). Coronary Artery Disease and Inherited Real Risk of CAD. Journal of Quantum Biophysical Semeiotics. http://www.sisbq.org/uploads/5/6/8/7/5687930/cad_caramel.pdf
31) Sergio Stagnaro, Simone Caramel. Inherited Real Risk of Coronary Artery Disease: pathophysiology, diagnosis and primary prevention. Epidemiology and Cardiovascular Prevention. Brief Communication. 8th International Congress of Cardiology in the internet. Published: 28 October 2013. FAC Federaciòn Argentina de Cardiologia http://fac.org.ar/8cvc/llave/tl054_stagnaro/tl054_stagnaro.php – PDF
32) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., http://www.nature.com/ejcn/journal/v67/n6/full/ejcn201337a.html [Medline]
34) Simone Caramel, Marco Marchionni and Sergio Stagnaro (2014). The Glycocalyx Bedside Evaluation Plays A Central Role in Diagnosing Type 2 Diabetes Mellitus and in its Primary Prevention. Treatment Strategies – Diagnosing Diabetes, Cambridge Research Centre, Volume 6 Issue 1, Pg 41-43. http://viewer.zmags.com/publication/0aafcae9#/0aafcae9/1
35) Mario Siniscalchi, Simone Caramel, Sergio Stagnaro (2016). Quando il fonendoscopio aiuta il cardiologo. Cuore e Vasi. Anno XXXVII • N. 3-4/2015, dicembre. Pg.15.
Regards
Dr Sergio Stagnaro
Sergio Stagnaro MD
Via Erasmo Piaggio 23/8,
16039 Riva Trigoso (Genoa) Italy
Phone 0390-0185-42315
Founder of Quantum Biophysical Semeiotics,
Honorary President of International Society of
Quantum Biophysical Semeiotics (SISBQ)
www.semeioticabiofisica.it
www.sisbq.org
www.sergiostagnaro.wordpress.com
PS!
Honestly I inform you all about the publbication of this mail in my La Voce di SS, https://sergiostagnaro.wordpress.com/